Defining Stromal-Cancer Cell Interactions For Xenografting Human Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$559,635.00
Summary
Prostate Cancer research continues to be hindered by a lack of laboratory models to understand disease progression and design new drugs to cure the disease. In this study, we propose to use a new and reliable method of growing human prostate cancer tissue in mice. Using this model, we will investigate the role of hormone signalling and cellular communication in prostate cancer that may lead to new therapies for men diagnosed with organ-confined disease.
The Molecular Basis To The Development And Function Of The Thymic Microenvironment.
Funder
National Health and Medical Research Council
Funding Amount
$227,036.00
Summary
The ability of the body to defend itself against infection is dependent on white cells in the blood called T lymphocytes, so-named because they are produced in the thymus gland. In the absence of these T cells, there is severe immunodeficiency. On other hand if the T cells are hyperactive, they can confuse their role and destroy normal tissues (autoimmunity). Imbalances in the types of T cells can also predispose patients to allergies and failures in responses to tumours. This project seeks to i ....The ability of the body to defend itself against infection is dependent on white cells in the blood called T lymphocytes, so-named because they are produced in the thymus gland. In the absence of these T cells, there is severe immunodeficiency. On other hand if the T cells are hyperactive, they can confuse their role and destroy normal tissues (autoimmunity). Imbalances in the types of T cells can also predispose patients to allergies and failures in responses to tumours. This project seeks to identify the genes required to create T cells in the thymus. Specifically it addresses the structural cells of the thymus which provide the unique environment for converting bone marrow precursors exclusively into T lymphocytes. Understanding the genetic and thus molecular basis to this will be very important biologically but may also provide more sophisticated stratgies for treating diseases on T cell origin.Read moreRead less