Regulation Of Key Pathways Causing Peri-implant Bone Loss.
Funder
National Health and Medical Research Council
Funding Amount
$403,639.00
Summary
The failure of bone prostheses is becoming a major health problem in our aging population. Despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is now apparent that most implants fail due to bone loss around them which leads to loosening. This project aims to obtain a better understanding of the causes of implant failure and find ways to extend the life of these implants .
Clinical Outcomes, Safety And Incremental Cost Effectiveness Of Multi-level Airway Surgery In Patients With Moderate-severe Obstructive Sleep Apnea (OSA) Who Have Failed Medical Management
Funder
National Health and Medical Research Council
Funding Amount
$652,794.00
Summary
Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to ....Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to improved patient outcomes.Read moreRead less
Conservation management of the endangered skink Liopholis slateri. Slater's skink was common in Central Australia 30 years ago, but is now endangered. The project will investigate the lizard response to changing environmental conditions and will develop biological insights that will be important for its conservation.
Adaptive Morphology and Evolution of Invasive Rabbits and Hares. This project aims to uncover the morphological variation that allows rapid adaptive evolution in two invasive species, the rabbit and hare. This project expects to generate new knowledge at the interface between invasion biology and evolutionary biology, using cutting-edge methods to phenotype widespread populations. This project will address key inter-related hypotheses of rapid adaptive evolution at temporal, spatial and phylogen ....Adaptive Morphology and Evolution of Invasive Rabbits and Hares. This project aims to uncover the morphological variation that allows rapid adaptive evolution in two invasive species, the rabbit and hare. This project expects to generate new knowledge at the interface between invasion biology and evolutionary biology, using cutting-edge methods to phenotype widespread populations. This project will address key inter-related hypotheses of rapid adaptive evolution at temporal, spatial and phylogenetic scales, particularly about changing morphologies involved role in locomotion and dispersal ability. Expected outcomes of this project include a comprehensive phenotypic database of these two species and identifying how these invasive species are adapting to the Australian landscape.Read moreRead less
Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
Transport risk pathways for emerging invasive species. Our Australian economy depends on tourism and trade and this carries unavoidable risks for the introduction and establishment of new invasive pests and diseases. This project will build datasets from four real-world problem agenda in global invasion biology. Informed by these data, this project will develop and apply state-of-the-art mathematical transport models to predict the risks and frequency of future biological invasion events. The pr ....Transport risk pathways for emerging invasive species. Our Australian economy depends on tourism and trade and this carries unavoidable risks for the introduction and establishment of new invasive pests and diseases. This project will build datasets from four real-world problem agenda in global invasion biology. Informed by these data, this project will develop and apply state-of-the-art mathematical transport models to predict the risks and frequency of future biological invasion events. The project will contribute directly to safeguarding Australia from invasive pests and diseases.Read moreRead less
Development of genetic technology for rodent population suppression. Vertebrate pests cost Australia over $1 billion each year in agricultural losses and environmental damage and novel strategies are urgently required to tackle this massive challenge. Newly proposed “gene drives”, which might rapidly spread through populations, have enormous potential for the sustained management and even eradication of pests. Through innovative application of cutting-edge genome editing approaches, this proposa ....Development of genetic technology for rodent population suppression. Vertebrate pests cost Australia over $1 billion each year in agricultural losses and environmental damage and novel strategies are urgently required to tackle this massive challenge. Newly proposed “gene drives”, which might rapidly spread through populations, have enormous potential for the sustained management and even eradication of pests. Through innovative application of cutting-edge genome editing approaches, this proposal aims to develop gene drive technology in mice as a prototypical vertebrate pest species. We will also develop cutting-edge mathematical models of rodent gene drives to identify crucial parameters for efficacious employment and investigate potential for impact on non-target populations.Read moreRead less
An integrated tool for informing pest management: modelling range shifts for an invasive vertebrate in response to climate change. Invasive species and climate contribute directly to loss of biodiversity and economic productivity. This research project focuses on providing user-orientated tools that enable a strategic approach to European rabbit management and vertebrate pest control in Australia in response to anticipated climate and land-use change.
Radiostereometric Analysis Of The Effect Of A Large Articulation On Prosthetic Wear And Migration After Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$192,186.00
Summary
At total hip replacement, there has been a recent trend to use prostheses with a larger ball and liner in the socket. This may decrease the risk of post-operative dislocation, but may also increase the amount of wear, leading to bone loss and loosening of prostheses, which may then require replacement. This project will use a special type of x-ray to determine whether wear and movement of these new prostheses is clinically acceptable, so that they can be used with confidence in patients.
The Risks And Benefits Of Contemporary Total Hip Replacement
Funder
National Health and Medical Research Council
Funding Amount
$493,530.00
Summary
The number of hip replacements undertaken in Australia is steadily increasing. The most common complications of hip replacements are dislocation and loosening due to bone loss around the implant, requiring complex and expensive revision surgery. This study will investigate the incidence of dislocation and, using a new diagnostic imaging technique, the incidence and amount of bone loss around a relatively new prosthetic material, the outcomes of which are not known despite its increasing use.