Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.
Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits a ....Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits also include the development of new cutting-edge methodologies for the investigation of Australian desert landscapes, comprehensive baseline data of how this region has evolved prior to European colonization and resolving why no Pleistocene aged archaeological sites have been found in the region.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100220
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Sonic drilling to provide contamination-free core sampling of rock and unconsolidated sediment. Australia is the world's driest inhabited continent. Understanding environmental and climatic changes, from the temperate period when humans arrived about 50,000 years ago to the present state of widespread aridity, is crucial for modelling future climate change. This facility will provide new generation drilling equipment which is necessary to obtain accurate records.
Effective and efficient corporate tax enforcement. This project uses economic theory and experimental tests in order to inform tax authorities on how to best audit tax receipts from corporations. The project will result in advice on how audit resources should be allocated across firms, if minimising corporate tax evasion and at the same time maximising social welfare are the authority's objective.
Unravelling how aquatic coastal networks regulate nitrogen removal . The aim of this project is to determine the nitrogen removal pathways of the coastal zone using a number of innovative field and modelling approaches. Little is known about how the complex coastal landscape controls trade-offs that maximise nitrogen removal but minimise nitrous oxide (a potent greenhouse gas) emissions. The outcomes of this study will significantly advance our understanding of the coastal zone in regional and g ....Unravelling how aquatic coastal networks regulate nitrogen removal . The aim of this project is to determine the nitrogen removal pathways of the coastal zone using a number of innovative field and modelling approaches. Little is known about how the complex coastal landscape controls trade-offs that maximise nitrogen removal but minimise nitrous oxide (a potent greenhouse gas) emissions. The outcomes of this study will significantly advance our understanding of the coastal zone in regional and global nitrogen budgets. This will provide significant benefits such as a new science-based quantitative framework to facilitate best practice management to reduce terrestrial nitrogen loads and associated downstream impacts such as eutrophication, and reduce nitrous oxide emissions and associated global warming.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100079
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered o ....A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered ocean where waves and ice interact, causing ice-breaking and wave attenuation. This unique facility will enable experiments in sea-ice-wave interactions in a controlled environment. Water and air temperature, thermal stratification, water waveform and ice properties will be adjusted in order to preserve key characteristics of the complex ocean environment.Read moreRead less
A Novel Metabolic Role For UDP Glycosyltransferase 8 (UGT8)
Funder
National Health and Medical Research Council
Funding Amount
$419,144.00
Summary
The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.