A BubR1-centred Network For Non-invasively Measuring Human Oocyte Quality
Funder
National Health and Medical Research Council
Funding Amount
$532,207.00
Summary
Oocyte quality is the most important determinant of pregnancy outcome. Selecting the best oocytes for fertility treatments like IVF would therefore greatly improve success rates and reduce costs. We have identified master oocyte regulators and have applied novel digital technology to measure these regulators in a single oocyte. This project will apply this expertise to develop new approaches for evaluating an oocyte’s potential thereby informing its suitability for use in fertility treatment.
The Legacy Of The Egg: How Maternal Factors Set Offspring Health And Lifecourse Potential
Funder
National Health and Medical Research Council
Funding Amount
$697,605.00
Summary
Before an oocyte is fertilised, it contains all the material needed to form an embryo, and a legacy of information about its environment. My research aims to discover how oocyte signals, accumulated before conception, determine the health of the future individual; and then harness this knowledge to improve female reproductive health and generate new approaches to treat infertility and to optimise healthy embryo development in all pregnancies.
The Obesity Prone Oocyte- Causes, Consequences, Treatments
Funder
National Health and Medical Research Council
Funding Amount
$516,159.00
Summary
Obesity is perpetuated from mothers to offspring, in part due to changes in the oocyte (egg) that affect embryo growth. We have discovered that obesity causes changes in the mitochondria (the energy producers) of the egg. We hypothesise this causes long-lasting changes to embryo metabolism and will test, in mice, novel treatments to reverse the detrimental effects. The project will show how obesity affects embryo metabolism and growth, and determine whether defects can be prevented by drugs or l ....Obesity is perpetuated from mothers to offspring, in part due to changes in the oocyte (egg) that affect embryo growth. We have discovered that obesity causes changes in the mitochondria (the energy producers) of the egg. We hypothesise this causes long-lasting changes to embryo metabolism and will test, in mice, novel treatments to reverse the detrimental effects. The project will show how obesity affects embryo metabolism and growth, and determine whether defects can be prevented by drugs or lifestyle changes.Read moreRead less