Understanding Mitochondrial DNA Segregation And Transmission.
Funder
National Health and Medical Research Council
Funding Amount
$512,449.00
Summary
We inherit our mitochondrial DNA from our mothers. Mutations to mitochondrial DNA can give rise to severely debilitating diseases that can be passed from one generation to the next. The aims of this application are to understand how mutant mitochondrial DNA is selected for; when it affects energy production during development; and to ensure that certain reproductive strategies do not result in the adverse transmission of mitochondrial DNA that will affect subsequent generations.
Identifying Mitochondrial Genome Variants Associated With Familial Migraine Susceptibility
Funder
National Health and Medical Research Council
Funding Amount
$443,273.00
Summary
New therapeutic targets for migraine are desperately needed. Although studies have identified some migraine genes there remains considerable underlying genetic variation to be characterised. This study aims to identify functional variants in the mitochondrial genome that contribute to migraine susceptibility, utilising the isolated Norfolk Island population. Outcomes will determine the significance of the variants identified, potentially leading to new diagnostics.
Understanding The Pathogenesis Of Mitochondrial Disease Using IPS Cells
Funder
National Health and Medical Research Council
Funding Amount
$640,372.00
Summary
Induced pluripotent stem (iPS) cells are stem cells derived from adult skin cells that can be converted into cell types such as neurons. iPS cells offer great promise in understanding and treating inherited disorders. However, there are concerns that the “epigenetic memory” of iPS cells has not been completely erased, which may limit the utility of iPS cells. We will evaluate and validate the use of iPS technology in mouse and human models of inherited disorders affecting energy generation.
Metabolic And Molecular Basis Of Embryo Signalling
Funder
National Health and Medical Research Council
Funding Amount
$409,836.00
Summary
Cells in the body are powered by mitochondria that essentially generate the energy required for development. This grant will determine how the environment affects the mitochondria in the developing embryo and determine the impacts to the embryo and pregnancy if a mitochondria is partially shut down.
UNDERSTANDING THE BENEFITS AND LIMITATIONS OF METAPHASE II SPINDLE TRANSFER
Funder
National Health and Medical Research Council
Funding Amount
$1,629,373.00
Summary
Mitochondrial DNA (mtDNA) diseases are transmitted from a mother's eggs to her children. However, the levels of affected mtDNA differ amongst her eggs. Consequently, a carrier would not know if the newborn child were to suffer from these diseases. Mitochondrial Donation offers couples the potential to have an unaffected child. We will undertake the most comprehensive study of mitochondrial donation using one of its associated approaches to determine if it produces healthy embryos and offspring.
Improving Oocyte Mitochondrial DNA Copy Number To Enhance Female Reproductive Capacity.
Funder
National Health and Medical Research Council
Funding Amount
$670,867.00
Summary
Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.
Precipitation in shallow convection over the Southern Ocean. This project aims to quantify the amount of precipitation over the Southern Ocean and identify the key dynamical and microphysical processes that lead to its development. Large uncertainties exist in the frequency and intensity of precipitation, which limits the ability to model the coupled Southern Ocean climate system. Observations from the RV Investigator, an Australian marine research vessel, have revealed heavy precipitation event ....Precipitation in shallow convection over the Southern Ocean. This project aims to quantify the amount of precipitation over the Southern Ocean and identify the key dynamical and microphysical processes that lead to its development. Large uncertainties exist in the frequency and intensity of precipitation, which limits the ability to model the coupled Southern Ocean climate system. Observations from the RV Investigator, an Australian marine research vessel, have revealed heavy precipitation events within the shallow convection commonly found between fronts that have not been captured by either satellite observations or numerical models. This project will improve weather forecasts, including precipitation, and climate projections over the Southern Ocean and the adjoining Antarctic and the southern part of Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102645
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The cause of the poleward shift of Earth's storm tracks and jet streams. Why do global climate models shift the atmospheric storm tracks and jet streams poleward in simulations of future climate? This project will determine the underlying causes of the most important circulation change that is projected to occur with increasing greenhouse gases, and will allow much more accurate regional climate projections.
From Pathogenesis To Therapeutics: Targeting Two Signalling Pathways As A Therapeutic Strategy To Treat Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$499,048.00
Summary
Preeclampsia is a serious complication of pregnancy that claims the lives of thousands of mothers and babies each year. There is no efficacious medical treatment besides delivery of the baby and placenta. Our lack of therapeutics is largely a result of our poor understanding of the disease. In this application we plan to thoroughly characterise two pathways we believe responsible for preeclampsia, effectively identifying many points at which new therapies could be targeted.
The dynamics of subtropical anticyclones and the connection to drought, heatwaves and bushfires in southern Australia. The aim of the project is to understand the dynamics of anticyclones (high pressure systems) in the region of southern Australia. The study of anticyclones in the region is important because of their very strong connection to rainfall in the winter, and heatwaves and bushfires in the summer, and because so little work has been done on understanding what is the defining feature o ....The dynamics of subtropical anticyclones and the connection to drought, heatwaves and bushfires in southern Australia. The aim of the project is to understand the dynamics of anticyclones (high pressure systems) in the region of southern Australia. The study of anticyclones in the region is important because of their very strong connection to rainfall in the winter, and heatwaves and bushfires in the summer, and because so little work has been done on understanding what is the defining feature of the climate of southern Australia. Understanding what controls the location and strength of these features will go a long way to explaining how the climate of southern Australia will change in a warmer world.Read moreRead less