Mitochondrial Damage Following Fetal Hypoxia Or Birth Asphyxia: Using Creatine To Preserve Mitochondrial Function
Funder
National Health and Medical Research Council
Funding Amount
$838,726.00
Summary
There is a need for a therapy that can be given before a mother gives birth to protect the baby should ‘oxygen starvation’ threaten the baby’s brain and other organs such as the heart, kidney, lungs, and the ability to breathe properly. We are suggesting that an increased intake of creatine is a very effective treatment against this threat, and its proven safety and ease of use recommends it for wide application, particularly in countries where the access to medical resources is poor.
Understanding Mitochondrial DNA Segregation And Transmission.
Funder
National Health and Medical Research Council
Funding Amount
$512,449.00
Summary
We inherit our mitochondrial DNA from our mothers. Mutations to mitochondrial DNA can give rise to severely debilitating diseases that can be passed from one generation to the next. The aims of this application are to understand how mutant mitochondrial DNA is selected for; when it affects energy production during development; and to ensure that certain reproductive strategies do not result in the adverse transmission of mitochondrial DNA that will affect subsequent generations.
Understanding The Pathogenesis Of Mitochondrial Disease Using IPS Cells
Funder
National Health and Medical Research Council
Funding Amount
$640,372.00
Summary
Induced pluripotent stem (iPS) cells are stem cells derived from adult skin cells that can be converted into cell types such as neurons. iPS cells offer great promise in understanding and treating inherited disorders. However, there are concerns that the “epigenetic memory” of iPS cells has not been completely erased, which may limit the utility of iPS cells. We will evaluate and validate the use of iPS technology in mouse and human models of inherited disorders affecting energy generation.
Metabolic And Molecular Basis Of Embryo Signalling
Funder
National Health and Medical Research Council
Funding Amount
$409,836.00
Summary
Cells in the body are powered by mitochondria that essentially generate the energy required for development. This grant will determine how the environment affects the mitochondria in the developing embryo and determine the impacts to the embryo and pregnancy if a mitochondria is partially shut down.
Improving Oocyte Mitochondrial DNA Copy Number To Enhance Female Reproductive Capacity.
Funder
National Health and Medical Research Council
Funding Amount
$670,867.00
Summary
Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.
From Pathogenesis To Therapeutics: Targeting Two Signalling Pathways As A Therapeutic Strategy To Treat Preeclampsia
Funder
National Health and Medical Research Council
Funding Amount
$499,048.00
Summary
Preeclampsia is a serious complication of pregnancy that claims the lives of thousands of mothers and babies each year. There is no efficacious medical treatment besides delivery of the baby and placenta. Our lack of therapeutics is largely a result of our poor understanding of the disease. In this application we plan to thoroughly characterise two pathways we believe responsible for preeclampsia, effectively identifying many points at which new therapies could be targeted.
The dynamics of subtropical anticyclones and the connection to drought, heatwaves and bushfires in southern Australia. The aim of the project is to understand the dynamics of anticyclones (high pressure systems) in the region of southern Australia. The study of anticyclones in the region is important because of their very strong connection to rainfall in the winter, and heatwaves and bushfires in the summer, and because so little work has been done on understanding what is the defining feature o ....The dynamics of subtropical anticyclones and the connection to drought, heatwaves and bushfires in southern Australia. The aim of the project is to understand the dynamics of anticyclones (high pressure systems) in the region of southern Australia. The study of anticyclones in the region is important because of their very strong connection to rainfall in the winter, and heatwaves and bushfires in the summer, and because so little work has been done on understanding what is the defining feature of the climate of southern Australia. Understanding what controls the location and strength of these features will go a long way to explaining how the climate of southern Australia will change in a warmer world.Read moreRead less
Understanding The Metabolic Consequences Of Impaired AMPKa2 And NNOS� In Skeletal Muscle: Implications For The Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$575,527.00
Summary
The inability of muscle to utilise sugar from the blood is a major problem that contributes to obesity and Type 2 diabetes. Since the number of people with these diseases will at least double by 2030, we need to find out what causes this problem. We will examine whether two muscle proteins that are impaired in obesity and Type 2 diabetes are also responsible for impaired sugar utilisation. We think that increasing these muscle proteins will fix the _sugar problem�, and remedy these diseases.
Biology Of EGFR Mutations In Glioblastoma Multiforme
Funder
National Health and Medical Research Council
Funding Amount
$287,445.00
Summary
The epidermal growth factor receptor (EGFR) is a protein that has a critical role in the development of normal cells. In glioma, the most lethal of the brain cancers, the EGFR is altered. These alterations result in uncontrolled activation of the EGFR, causing signals that promote the growth and survival of brain cancer. This grant seeks to understand the nature of the signals mediated by the altered EGFR, in turn helping us develop better therapeutics for the treatment of this deadly cancer.
Discovery Early Career Researcher Award - Grant ID: DE190100866
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
Intense thunderstorms in the tropics and subtropics under global warming. This project aims to determine how the frequency of intense tropical and subtropical thunderstorms will change as a result of future global warming. Climate models project that the energy available to such storms will increase in the future, but the reasons for this increase in available energy, and the implications for thunderstorm activity, remain uncertain. Using observations and high-resolution models, the project expe ....Intense thunderstorms in the tropics and subtropics under global warming. This project aims to determine how the frequency of intense tropical and subtropical thunderstorms will change as a result of future global warming. Climate models project that the energy available to such storms will increase in the future, but the reasons for this increase in available energy, and the implications for thunderstorm activity, remain uncertain. Using observations and high-resolution models, the project expects to generate new knowledge of the mechanisms driving changes in intense thunderstorm activity under climate change, and to provide more accurate projections of the frequency of intense thunderstorms in a warmer climate. This project should deliver benefits to sectors of the economy such as agriculture and transportation, which are significantly exposed to such hazards.Read moreRead less