Mechanism Of Signal Transduction And Receptor Activation In Ligand Gated Ion Channel Receptors
Funder
National Health and Medical Research Council
Funding Amount
$551,560.00
Summary
This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. This knowledge is important since the Cys-loop family of ligand gated ion channel receptors are responsible for a wide range of neuronal signalling and the control of both excitatory and inhibitory receptors. The Cys-loop receptors are modulated by both therapeutic drugs (eg. benzodiazepines, barbiturates, antiemetics) and by recre ....This project seeks to provide fundamental new information about the means by which neurotransmitter receptors, which mediate fast synaptic neurotransmission, operate. This knowledge is important since the Cys-loop family of ligand gated ion channel receptors are responsible for a wide range of neuronal signalling and the control of both excitatory and inhibitory receptors. The Cys-loop receptors are modulated by both therapeutic drugs (eg. benzodiazepines, barbiturates, antiemetics) and by recreational drugs (eg. alcohol, nicotine). They are also targets for development of new therapeutic drugs, such as allosteric modulators of nAChR for memory enhancement, or modulating GlyR to relieve spasticity or chronic pain. The project will use a range of molecular advances made by this and other laboratories to clarify how neurotransmitters enable their receptors to activate and signal. This fundamental information is of major medical significance as defective synaptic transmission, caused by mutations in ligand gated ion channel receptors, gives rise to a number of neurological and psychiatric disease states. The ligand gated receptors are also major targets for therapeutic drugs and the information gained in this study may also provide insights into new ways in which drugs could be used to enhance or inhibit synaptic signalling.Read moreRead less
Enhancing sensory perception and balance control in HMD-based VR. This project seeks to test a revolutionary new theoretical framework for understanding how we perceive our self-motion and maintain postural control when immersed in head-mounted display (HMD) virtual reality (VR). Photorealistic graphical simulations and artificial vestibular stimulation will be used to investigate how visual and non-visual information concerning self-motion is integrated in the brain. The outcomes will reveal ho ....Enhancing sensory perception and balance control in HMD-based VR. This project seeks to test a revolutionary new theoretical framework for understanding how we perceive our self-motion and maintain postural control when immersed in head-mounted display (HMD) virtual reality (VR). Photorealistic graphical simulations and artificial vestibular stimulation will be used to investigate how visual and non-visual information concerning self-motion is integrated in the brain. The outcomes will reveal how multisensory interaction influences our sensory perception and postural control during HMD VR. The knowledge gained is expected to generate new economic benefits by inspiring next-generation technologies that will optimise users' immersive experiences (e.g., virtual exploration and immersive gaming).Read moreRead less
Improving The Quality, Efficiency And Outcomes Of Stroke Care: Transforming Policy And Practice
Funder
National Health and Medical Research Council
Funding Amount
$466,492.00
Summary
This Fellowship supports an innovative body of research focussed on interventions to improve the care and outcomes of stroke. In Australia, stroke is a leading cause of death and disability. Unfortunately, variability in clinical care is resulting in some preventable disability. Over the next 4 years A/Prof Cadilhac will conduct clinical trials (n=2) and observational studies (n=3) aimed at improving the health system and outcomes of stroke. She uses economic evaluation to ensure findings are us ....This Fellowship supports an innovative body of research focussed on interventions to improve the care and outcomes of stroke. In Australia, stroke is a leading cause of death and disability. Unfortunately, variability in clinical care is resulting in some preventable disability. Over the next 4 years A/Prof Cadilhac will conduct clinical trials (n=2) and observational studies (n=3) aimed at improving the health system and outcomes of stroke. She uses economic evaluation to ensure findings are used for changing policy.Read moreRead less
The Intended and Unintended Impact of Policy for Adaptive Policy Management. The project aims to advance knowledge about the intended and unintended consequences of policy on health and well-being. It expects to innovate through new methods and novel data to integrate policy evaluation into the policy cycle in a timely fashion to prevent harm from occurring. It also leverages technology to track policy effects in real time. Expected outcomes of this project include new knowledge and enhanced pol ....The Intended and Unintended Impact of Policy for Adaptive Policy Management. The project aims to advance knowledge about the intended and unintended consequences of policy on health and well-being. It expects to innovate through new methods and novel data to integrate policy evaluation into the policy cycle in a timely fashion to prevent harm from occurring. It also leverages technology to track policy effects in real time. Expected outcomes of this project include new knowledge and enhanced policy infrastructure using new methods and interdisciplinary approaches. Significant benefits include improvements to: (1) policy management by government departments; (2) the health and wellbeing of the Australians they serve; (3) our Partners' capacity to consult governments on how technology can assist policy management. Read moreRead less
Using Health Economics To Strengthen Ties Between Evidence, Policy And Practice In Chronic Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,925,648.00
Summary
There is a major shortage of researchers with health economics expertise in Australia. This grant will provide training and development for a team of health economists to research chronic diseases covering issues such as: What is the value for money from investment in different treatments? How do such diseases affect the economic circumstances of families? How do we ensure that strategies to address illness work in practice and can be sustained? How do these issues get put on the policy agenda?
Equitable funding for health care: integrating social outcomes. This project will develop an innovative method for decision makers to achieve more equitable allocation of scarce health care resources. Health programs and treatments affect not just health (survival & health related quality of life) but also broader aspects of well-being (e.g. dignity, autonomy, safety). Our current methods for evaluating value for money in health do not capture these aspects. The project will provide benefit by a ....Equitable funding for health care: integrating social outcomes. This project will develop an innovative method for decision makers to achieve more equitable allocation of scarce health care resources. Health programs and treatments affect not just health (survival & health related quality of life) but also broader aspects of well-being (e.g. dignity, autonomy, safety). Our current methods for evaluating value for money in health do not capture these aspects. The project will provide benefit by allowing health system decision makers to achieve fairer allocation of resources across diverse health conditions, interventions and patient populations. Expected outcomes include a new tool for assessing interventions and measuring population health incorporating both health and social outcomes. Read moreRead less
STROKE123: A Collaborative, National Effort To Monitor, Promote And Improve The Quality Of Stroke Care In Hospitals And Patient Outcomes.
Funder
National Health and Medical Research Council
Funding Amount
$1,261,292.00
Summary
Stroke is a major public health issue in Australia. This Better Health Initiative partnership project is designed to rigorously evaluate a methodology to improve the monitoring and use of data for stroke, as well as an intervention to address evidence-practice gaps for essential interventions known to have a direct association with patient outcomes. The findings will provide a platform for national roll-out of appropriate and enhanced data collection solutions linked to an effective model for im ....Stroke is a major public health issue in Australia. This Better Health Initiative partnership project is designed to rigorously evaluate a methodology to improve the monitoring and use of data for stroke, as well as an intervention to address evidence-practice gaps for essential interventions known to have a direct association with patient outcomes. The findings will provide a platform for national roll-out of appropriate and enhanced data collection solutions linked to an effective model for improving clinical care and outcomes of stroke.Read moreRead less
Snake envenoming is a neglected tropical disease and results in numerous deaths, psychological problems and economic burden. Antivenoms aren't readily available in resource poor countries. The CRE will investigate the effects of venom and antivenom to improve understanding of human envenoming. It will also develop tests for early diagnosis of envenoming and undertake clinical trials of antivenom. These studies will be translated back into clinical practice to improve treatment of snake bites.
Regulatory Strategies To Promote Healthier Australian Diets
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Unhealthy diets are a leading cause of ill health. In contrast to our global leadership in tobacco control, Australia remains slow to use law as a tool to support healthy eating. This project will generate new insights on features of effective food policies to target excess sugar consumption. Using an innovative fusion of law and science, its findings will inform and accelerate current proposals to improve food labelling and tax sugary drinks to promote healthier Australian diets.
The Evaluation of Stuctures and Processes for Effective Client, Carer and Community Outcomes: A Model for Rural Mental Health Services. The South West Healthcare Area Mental Health Service ( Warnambool) has demonstrated according to key performance indicators, an effective system of service delivery. This evaluative research project seeks to identify key components within the organisational structures and processes of a rural mental health service that contribute to these effective outcomes fo ....The Evaluation of Stuctures and Processes for Effective Client, Carer and Community Outcomes: A Model for Rural Mental Health Services. The South West Healthcare Area Mental Health Service ( Warnambool) has demonstrated according to key performance indicators, an effective system of service delivery. This evaluative research project seeks to identify key components within the organisational structures and processes of a rural mental health service that contribute to these effective outcomes for clients. The research process will test these key components against other rural and urban mental health services in Victoria and will result in the development of a model for rural mental health service delivery of both local and national significance.Read moreRead less