Dopamine Neuron Ontogeny: Convergent Neurobiological Pathway For Risk Factors Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$337,214.00
Summary
Schizophrenia is associated with changes in dopamine (a signalling molecule in the brain). These changes are present prior to psychosis, suggesting they begin early in development. Our aims are to manipulate key factors in the development of brain dopamine systems to clarify their role in psychosis and schizophrenia. This work has the potential to identify early brain changes that lead to schizophrenia, which in turn may generate better diagnoses and outcomes for people with this disorder.
High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Delineating The Relationship Between Iron And Peroxisomal Disorders: The Role Of The Peroxisomal Enzyme GNPAT In Iron-Overload Disorders
Funder
National Health and Medical Research Council
Funding Amount
$700,767.00
Summary
Hereditary haemochromatosis is one of the most common genetic disorders in humans, affecting 1 in 200 Australians. We have identified a change in a peroxisomal gene which may affect iron levels in humans. The prevalence of this gene change in Australian haemochromatosis patients will be examined followed by a systematic analysis of how this protein controls iron levels in the body. Our goal is to identify and diagnose genetic changes which influence iron loading in haemochromatosis patients.
Discovery Early Career Researcher Award - Grant ID: DE150101212
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
In-situ Atomic-scale Deformation Mechanism of ultrafine Nanocrystalline Pt. Understanding the deformation of nanocrystalline (NC) metals is crucial for their practical application. So far, the deformation mechanism of ultrafine NC metals with grain size below 15 nanometre has been predicted by simulations which need to be verified experimentally. Using different in situ transmission electron microscopy deformation approaches, this project aims to determine deformation mechanisms of ultrafine NC ....In-situ Atomic-scale Deformation Mechanism of ultrafine Nanocrystalline Pt. Understanding the deformation of nanocrystalline (NC) metals is crucial for their practical application. So far, the deformation mechanism of ultrafine NC metals with grain size below 15 nanometre has been predicted by simulations which need to be verified experimentally. Using different in situ transmission electron microscopy deformation approaches, this project aims to determine deformation mechanisms of ultrafine NC platinum (Pt) at atomic-scale and to clarify how the deformation behaviour affects mechanical properties. The expected outcomes will advance the knowledge base in ultrafine NC metals and will provide guidance for developing advanced metallic materials with high strength/ductility that are the backbone for developing flexible and bendable devices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100146
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Ultra high vacuum scanning probe microscope facility. Ultra high-vacuum scanning tunneling microscopy underpins advances in the understanding of novel materials for electronics, engineering and medical applications, including thin-films, nanostructures, advanced semiconductors, nanostructured (organic or inorganic) conductors, and nanoscale interfaces (heteronanostructures). It is a core technique underpinning the new Superscience agenda in Future Technologies. A number of present and future re ....Ultra high vacuum scanning probe microscope facility. Ultra high-vacuum scanning tunneling microscopy underpins advances in the understanding of novel materials for electronics, engineering and medical applications, including thin-films, nanostructures, advanced semiconductors, nanostructured (organic or inorganic) conductors, and nanoscale interfaces (heteronanostructures). It is a core technique underpinning the new Superscience agenda in Future Technologies. A number of present and future research fields will benefit from the presence of this instrument, which will enhance Australia's competitiveness in nanotechnology research and development. Training of PhD and graduate students in this area is essential to exploit the potentiality of nanotechnology for the future benefit of Australia.Read moreRead less
Crossing quantum-classical boundaries in a single particle. This project is aimed at constructing and observing an individual quantum system that can exhibit chaotic behaviour under controllable conditions. It is a long-sought goal of modern physics that can become reality for the first time in the world, thanks to the unique availability in Australia of the most quantum-coherent single spin ever made and a long history of theoretical advances in the field. Turning a spin into a chaotic system w ....Crossing quantum-classical boundaries in a single particle. This project is aimed at constructing and observing an individual quantum system that can exhibit chaotic behaviour under controllable conditions. It is a long-sought goal of modern physics that can become reality for the first time in the world, thanks to the unique availability in Australia of the most quantum-coherent single spin ever made and a long history of theoretical advances in the field. Turning a spin into a chaotic system will uncover the true nature of the quantum-classical boundary, and verify whether an underlying classical chaotic dynamics ultimately influences the behaviour of quantum systems. It is expected that the discoveries made will illuminate the path towards the technological exploitation of increasingly complex quantum devices.Read moreRead less
SARA: Delineating Its Association With The Onset And Development Of Liver Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$865,972.00
Summary
Liver disease, a significant burden on society, affects many in the prime of their life. Scarring of the liver is a response to injury due to many factors including alcohol, viruses, obesity, and fatty-liver disease. We have identified a protein associated with liver injury. In this project we will perform a systematic analysis to understand the role of this protein in injury progression. Ultimately we intend to develop tools to prevent and treat liver injury.
Surface and Interface Engineering for Superconducting Quantum Circuits. The limiting factor for current quantum computers is a process called decoherence. This project aims to identify new strategies to reduce decoherence in quantum computer components using an interdisciplinary approach based on quantum physics, materials science, and engineering. This project involves investigating the effect of
atomically sharp interfaces on decoherence and using capping layers to control and/or inhibit oxide ....Surface and Interface Engineering for Superconducting Quantum Circuits. The limiting factor for current quantum computers is a process called decoherence. This project aims to identify new strategies to reduce decoherence in quantum computer components using an interdisciplinary approach based on quantum physics, materials science, and engineering. This project involves investigating the effect of
atomically sharp interfaces on decoherence and using capping layers to control and/or inhibit oxide growth that reduce the contribution of interfaces to decoherence. Expected outcomes of this project include development of solutions to fabricate long-lived superconducting qubits benefiting superconducting quantum technologies and making a significant step towards realisation of a practical quantum computer.Read moreRead less