Utilisation of dense gas technology for the development of controlled release active pharmaceutical ingredients (API) delivery systems. The aim of this project is to develop an orally administered drug formulation for the treatment of irritable bowel syndrome and other diseases of the colon. Irritable bowel syndrome is a debilitating condition and the cost to society is similar to that of asthma. As such, the project has the potential to have a major impact on society.
Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Photodesorption Phenomena and Photoreactive Nanosorbent Materials for Water and Wastewater Purification. Introducing more efficient production of drinking water and wastewater treatment methods for reuse is important to address increasing water scarcity in Australia. The proposed project will develop a water purification technology to remove pollutants using a recently discovered process. This process offers simple and affordable operation that is clean, robust and requires minimal attention. Th ....Photodesorption Phenomena and Photoreactive Nanosorbent Materials for Water and Wastewater Purification. Introducing more efficient production of drinking water and wastewater treatment methods for reuse is important to address increasing water scarcity in Australia. The proposed project will develop a water purification technology to remove pollutants using a recently discovered process. This process offers simple and affordable operation that is clean, robust and requires minimal attention. The technology is particularly suitable for small-scale applications in rural and remote areas, and has significant export potential. The project will strengthen established links between Australian and Korean research centres through the production of improved nanomaterials, and the development of the novel water purification technologyRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100036
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for hi ....A customised triple-beam microscope for precise fabricating/characterising . This project aims to establish a customised triple-beam microscope to enable precise fabrication and polishing (using ion beams) and characterisation (using electron beam) of a wide range of advanced materials. It will provide solutions to prepare ultra-high quality and artefact-free specimens for transmission electron microscopy studies, and allow fabrication of unique nanostructures and nanostructured templates for high-performance applications. The customised features of the proposed instrument are the first of its kind in Australia. The new knowledge developed through this project will significantly impact on scientific insights and practical applications of new materials related to physics, chemistry, biology, geology and engineering.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Nanostructured Silicon-Based Tandem Solar Cells. The expected outcome from the project is a new generation of low-cost silicon solar cell that will significantly reduce the costs of generating electricity from sunlight. Solar cells are presently the world's most rapidly growing energy source, with Australians and Australian companies already major players in the associated rapidly expanding industry. Solar cells represent the most benign technology yet suggested for supplying the world's future ....Nanostructured Silicon-Based Tandem Solar Cells. The expected outcome from the project is a new generation of low-cost silicon solar cell that will significantly reduce the costs of generating electricity from sunlight. Solar cells are presently the world's most rapidly growing energy source, with Australians and Australian companies already major players in the associated rapidly expanding industry. Solar cells represent the most benign technology yet suggested for supplying the world's future energy needs. A cleaner environment in the future than would otherwise be likely is another expected outcome as is the creation of major new opportunities for Australian industry.Read moreRead less
The Silicon Single Electron Pump: A New World Standard for Electric Current. This project seeks to develop a new ultra-high-precision current standard, providing a missing link in today’s world standards for electrical measurement. Although highly accurate metrological standards are available for both voltage and resistance, there is no equivalent current standard available. The project aims to create nanoelectronic charge-pump devices that can generate a highly accurate output current. This pro ....The Silicon Single Electron Pump: A New World Standard for Electric Current. This project seeks to develop a new ultra-high-precision current standard, providing a missing link in today’s world standards for electrical measurement. Although highly accurate metrological standards are available for both voltage and resistance, there is no equivalent current standard available. The project aims to create nanoelectronic charge-pump devices that can generate a highly accurate output current. This project plans to use silicon-based single-electron-transistor technology to undertake high-precision measurements. The project expects to contribute to the technological basis for a new world current standard.Read moreRead less
Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commerci ....Nanoscale silicon field-effect transistor diagnostic technology. This project aims to overcome barriers to the implementation of silicon field-effect transistor biosensors. It will investigate the biosensors’ physical and structural properties. This knowledge, combined with technological and conceptual advances, could foster the development of an advanced and translational point-of-care diagnostic technology to rapidly and sensitively detect malignant tissues. Such technology would have commercial potential and important societal benefits.Read moreRead less
A Transportable Self-referenced Quantum Current Standard on a Silicon Chip. The field of metrological science strives for continuous improvement in precision and reproducibility, a goal only achievable by exploiting the fundamental constants of nature. In electrical metrology, both voltage (V) and resistance (R) standards have reached this milestone, but not current (I). We aim to develop novel self-referenced nanoelectronic charge-pump devices that can generate a highly accurate, error-detectab ....A Transportable Self-referenced Quantum Current Standard on a Silicon Chip. The field of metrological science strives for continuous improvement in precision and reproducibility, a goal only achievable by exploiting the fundamental constants of nature. In electrical metrology, both voltage (V) and resistance (R) standards have reached this milestone, but not current (I). We aim to develop novel self-referenced nanoelectronic charge-pump devices that can generate a highly accurate, error-detectable output current utilising Australian-developed silicon-based single-electron transistor technology. We will undertake high-precision measurements in collaboration with leading European standards institutes and researchers, establishing the technological basis for a new world current standard that is reproducible worldwide.Read moreRead less
Single electron pumping for current measurement standards. Precision measurement standards for electric current and voltage are necessary to ensure the safe and accurate operation of much of the electronic equipment that underpins modern society. This project will develop a new ultra-high-precision current standard, providing a missing link in today's world standards for electrical measurement.