Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug develo ....Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug development, and also for performing clinical diagnostics in a rural area. This will significantly impact on the quality of life of the Nation as a whole, not only due to expedient diagnosis and treatment which has obvious health benefits, but also in the considerable financial benefits that result from early and efficient treatment. Read moreRead less
Micro Process Plants - Non-Newtonian flow and particle synthesis in confined geometries. Understanding the flow behaviour of well characterised non-Newtonian fluids within microfluidic and nanofluidic devices is of vital importance to development of novel high-value added services, products and devices within Australia's burgeoning biotechnology, environmental technology, communications and information technology industries. The outcomes of this project will provide new 'systematic' design stand ....Micro Process Plants - Non-Newtonian flow and particle synthesis in confined geometries. Understanding the flow behaviour of well characterised non-Newtonian fluids within microfluidic and nanofluidic devices is of vital importance to development of novel high-value added services, products and devices within Australia's burgeoning biotechnology, environmental technology, communications and information technology industries. The outcomes of this project will provide new 'systematic' design standards for microdevice manufacture for these industries, ultimately leading to the creation of new, exciting avenues for tailoring novel biotechnology and 'point-of-care' products for Australia.Read moreRead less
Oral Insulin Delivery facilitated by Enteric Coating using Dense Gas Technologies. Insulin dependant diabetes is a rapidly growing disease. The current method for insulin delivery to the patient is by injection, which is inconvenient. Oral delivery of insulin is a more acceptable method. It is proposed to develop a dense gas technique to coat insulin with a pH sensitive polymer to protect it from the acidic environment of the stomach. Insulin can then be released at the high pH of the intestin ....Oral Insulin Delivery facilitated by Enteric Coating using Dense Gas Technologies. Insulin dependant diabetes is a rapidly growing disease. The current method for insulin delivery to the patient is by injection, which is inconvenient. Oral delivery of insulin is a more acceptable method. It is proposed to develop a dense gas technique to coat insulin with a pH sensitive polymer to protect it from the acidic environment of the stomach. Insulin can then be released at the high pH of the intestine when the polymer is dissolved. Particle size control is feasible by dense gas processes by manipulating operating parameters. Advantages include low residual solvent and manufacture at ambient temperatures.Read moreRead less
New approaches to inhibition of activity of HIV integrase. This project aims to assist in the development of novel anti-HIV drugs that will benefit the 17000 Australians and more than 33 million people worldwide who are currently suffering with this terrible disease. The project will utilise state-of-the-art approaches in structure-based drug design to identify and synthesise compounds as leads for the development of anti-HIV drugs. Furthermore, the project will provide invaluable training for t ....New approaches to inhibition of activity of HIV integrase. This project aims to assist in the development of novel anti-HIV drugs that will benefit the 17000 Australians and more than 33 million people worldwide who are currently suffering with this terrible disease. The project will utilise state-of-the-art approaches in structure-based drug design to identify and synthesise compounds as leads for the development of anti-HIV drugs. Furthermore, the project will provide invaluable training for the researchers involved and enhance the relationship between the academic and commercial collaborators.Read moreRead less
Building advanced polymeric nanotubes for targeted drug delivery. Advanced drug delivery devices have major commercial applications in fighting diseases like cancer and infectious viruses. The success of this project will provide fundamental knowledge for the design of new drug delivery devices based on polymeric nanotubes. The project will also further advance Australia's nano- and bio-technological research and industries. This project will also provide additional benefit for developing contro ....Building advanced polymeric nanotubes for targeted drug delivery. Advanced drug delivery devices have major commercial applications in fighting diseases like cancer and infectious viruses. The success of this project will provide fundamental knowledge for the design of new drug delivery devices based on polymeric nanotubes. The project will also further advance Australia's nano- and bio-technological research and industries. This project will also provide additional benefit for developing controlled release systems in drug delivery and artificial vessels, and improve sensitivity in molecular sensors. The pioneering work proposed will ensure that Australia remains at the forefront of innovative scientific research within the rapidly advancing disciplines of nanotechnology and novel macromolecular design.Read moreRead less
Gas-phase and catalytic reaction of halons under reducing conditions. Halons are ozone-depleting substances, but their use continues in most countries. This project pursues techniques to convert, rather than destroy, halons into benign and useful products. The aims of this project are to gain a fundamental understanding of the reactions of the most commonly used halons, 1301, 1211 and 2402, and perform a detailed examination of catalytic processes for conversion of halons to HFCs. The primary ....Gas-phase and catalytic reaction of halons under reducing conditions. Halons are ozone-depleting substances, but their use continues in most countries. This project pursues techniques to convert, rather than destroy, halons into benign and useful products. The aims of this project are to gain a fundamental understanding of the reactions of the most commonly used halons, 1301, 1211 and 2402, and perform a detailed examination of catalytic processes for conversion of halons to HFCs. The primary outcome from the study will be the development of a process specifically designed to convert halons into useful products. This will assist with efforts to phase out continued halon use.Read moreRead less
Transformation of halons and CFC to valuable products through their reaction with methane. Halons and CFCs are well known as ozone depleting substances (ODS). This project pursues the development of a novel process to transform stockpiles of halons and CFCs into vinylidene difluoride (C2H2F2). Vinylidene difluoride is a highly valued commodity, used in the synthesis of heat resistant materials. The primary aim of this research is to gain understanding of the role of catalysts during conversion o ....Transformation of halons and CFC to valuable products through their reaction with methane. Halons and CFCs are well known as ozone depleting substances (ODS). This project pursues the development of a novel process to transform stockpiles of halons and CFCs into vinylidene difluoride (C2H2F2). Vinylidene difluoride is a highly valued commodity, used in the synthesis of heat resistant materials. The primary aim of this research is to gain understanding of the role of catalysts during conversion of CFC 12 and halon 1211 into the desired reaction product. The signifigance of the project is that it will facilitate development of a process for non-destructive treatment of ozone depleting substances. The major outcome of the proposed research is it will lay the technical foundation for the development of an energy efficient process to convert rather than destroy these ODS.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100142
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An integrated liquid chromatography mass spectrometry nuclear magnetic resonance (LC-MS-NMR) facility for applications in proteomics and organic chemistry. This application completes the requested liquid chromatography mass spectrometry nuclear magnetic resonance (LCMS-NMR) facility and will allow the training of over 150 researchers, significantly enhancing their research productivity and translation of outcomes in areas of national importance. New breakthroughs in drug development, smart mate ....An integrated liquid chromatography mass spectrometry nuclear magnetic resonance (LC-MS-NMR) facility for applications in proteomics and organic chemistry. This application completes the requested liquid chromatography mass spectrometry nuclear magnetic resonance (LCMS-NMR) facility and will allow the training of over 150 researchers, significantly enhancing their research productivity and translation of outcomes in areas of national importance. New breakthroughs in drug development, smart materials, organic electronic materials and biomedical research require routine access to cutting edge technology. The LCMS-NMR augments the capabilities of our research teams at the forefront of these efforts. These include understanding the impact of the environment on plant and animal development, pest animal control, development of new biotechnology tools, new drugs and new methods for the detection of narcotics and explosives.Read moreRead less
New Strategies for Modelling Polyoxometalates. Polyoxometalates are a versatile class of genuine nanomaterials with remarkable chemical and physical properties and dimensions ranging from tens to tens of thousands of atoms. Designing functional materials which exploit their enormous potential is limited by practical difficulties in their structural characterization and restrictions on our ability to model their behaviour. In this project, we will develop a new strategy for computer modelling of ....New Strategies for Modelling Polyoxometalates. Polyoxometalates are a versatile class of genuine nanomaterials with remarkable chemical and physical properties and dimensions ranging from tens to tens of thousands of atoms. Designing functional materials which exploit their enormous potential is limited by practical difficulties in their structural characterization and restrictions on our ability to model their behaviour. In this project, we will develop a new strategy for computer modelling of polyoxometalates based on the classical molecular mechanics approach and high-level techniques. This novel line of attack will be exploited in the characterization of large and highly substituted derivatives which are key to developing functional materials.Read moreRead less
The role of floc structure in the formation of sediments and filter cakes. The project aims to understand at a fundamental level if and in what way the fractal structure of aggregates of fine particles is preserved when forming sediments and filter cakes. The effect of this structure on processes for separating solids and liquids is significant: each year, millions of dollars stand to be saved though more efficient filtration, and more efficient thickening of mineral slurries. Improved understan ....The role of floc structure in the formation of sediments and filter cakes. The project aims to understand at a fundamental level if and in what way the fractal structure of aggregates of fine particles is preserved when forming sediments and filter cakes. The effect of this structure on processes for separating solids and liquids is significant: each year, millions of dollars stand to be saved though more efficient filtration, and more efficient thickening of mineral slurries. Improved understanding allows intelligent design of flocculation systems to optimise the performance of downstream solid - liquid separation processes, maximising economic and environmental returns.Read moreRead less