Identifying Novel Disease Genes In Abnormalities Of The Eye
Funder
National Health and Medical Research Council
Funding Amount
$123,454.00
Summary
The macula is located in the centre at the back of the eye and is essential for detailed and colour vision. There are familial forms of macular abnormalities and many elderly patients suffer from age-related macular degeneration. The gene function that is critical for the maintenance of a healthy macula is not fully known. In this project, a novel process in maintaining macular health will be investigated to identify the underlying genetic cause and associated functional defects.
The Biology Of Cervical Disc Damage And Stem Cell Applications For Repair.
Funder
National Health and Medical Research Council
Funding Amount
$82,554.00
Summary
Disruption of the cervical disc by degeneration or trauma is common and therefore a major public health issue causing significant pain and disability in the community. The understanding of the changes that occur in disc degeneration would be greatly enhanced by comparison with changes that occur in normal discs and in discs recently disrupted by trauma. Potential applications of adult stem cells or their derivatives for disc repair and regeneration will be explored.
The Role Of FHL Proteins In The Pathology Of Muscular Dystrophies: Identification Of Novel Therapeutic Targets
Funder
National Health and Medical Research Council
Funding Amount
$61,355.00
Summary
Scientists at Monash University have recently identified a protein called FHL1 which promotes skeletal muscle repair-growth and may reverse the muscle degeneration seen in inherited muscular dystrophies. This study will investigate whether FHL1 expression can improve muscle mass in mouse models of muscular dystropy. In doing so, this research improve out understanding of the molecular processes that cause muscular dystrophies and thereby lead the way to new therapies for this family of diseases.
Functional Assessment Of Bioenergetic Defects In Hereditary Spastic Paraplegia
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Hereditary spastic paraplegia (HSP) is a degenerative, hereditary disorder which affects the legs. Currently there are no treatments that target the disease process. We seek to identify the genes responsible for this condition in a group of Australian patients. Cell samples obtained from these patients will be tested for energy defects. We hope to improve our understanding of the underlying disease processes in order to find new ways to prevent, treat and cure this condition.