Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100015
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need ....An Ultra High Resolution Mass Spectrometry Facility for Lipidomics Research. An ultra-high-resolution mass spectrometry facility for lipidomics research:
This proposal aims to establish an ultra-high-resolution, accurate mass spectrometry facility in Australia for comprehensive lipidomics research. The platform would consist of a Thermo Scientific Orbitrap Fusion mass spectrometer interfaced with ultra-high-pressure high-performance liquid chromatography. This proposal will address a major need for advanced mass spectrometry-based lipid analysis capabilities across mammalian, plant, parasite, and microalgae research disciplines, as well as enabling fundamental studies of lipid separation, chemistry and reactivity. The instrumentation would be applicable to a diverse range of projects including studies of the role of lipid metabolism in mammalian biochemistry and cell biology, plant biology and parasitology, and micro algae biofuel production.Read moreRead less
Can Skin Infection With Group A Streptococcus Cause Acute Rheumatic Fever?
Funder
National Health and Medical Research Council
Funding Amount
$459,450.00
Summary
It is traditionally taught that the cause of acute rheumatic fever (ARF) is always infection of the throat with the bacterium group A streptococcus (GAS). However, in Aboriginal communities of the Top End of the Northern Territory the incidence of ARF is the highest reported in the world, yet GAS is uncommonly isolated from the throat. There is further information to suggest that GAS skin sores may underlie many cases of ARF. If this were proven, it would completely alter the traditional view of ....It is traditionally taught that the cause of acute rheumatic fever (ARF) is always infection of the throat with the bacterium group A streptococcus (GAS). However, in Aboriginal communities of the Top End of the Northern Territory the incidence of ARF is the highest reported in the world, yet GAS is uncommonly isolated from the throat. There is further information to suggest that GAS skin sores may underlie many cases of ARF. If this were proven, it would completely alter the traditional view of the cause of ARF, and have important implications for prevention of ARF around the world. Presently, these approaches focus on diagnosing and treating sore throat, but no country has proven that such a program can be successful in substantially reducing new cases of ARF. If it was known that skin infection could lead to ARF, then countries (including Australia) could emphasise the importance of skin health programs. A further benefit of this knowledge would be to influence GAS vaccine development, which presently is largely focused on the prevention of sore throat. A different possibility has recently been raised - that the cause of ARF may not always be GAS, but instead that the related bacteria GCS and GGS may have the potential to cause this disease. Proof of this hypothesis would even more dramatically alter our understanding of disease causation, prevention, and vaccine development. We propose to determine the cause of ARF in Aboriginal communities by regularly swabbing families of people with a history of ARF, and using genetic fingerprinting of the bacteria from the skin and throat swabs. When cases of ARF occur, we will be able to determine the site and type of infection that precipitated the attack. We will conduct a related study in more communities, in which we will swab family members of people with ARF and of control families (without ARF) to determine the bacteria most commonly isolated from ARF families.Read moreRead less
Flavour enhancing functional feeds for farmed Barramundi. This project aims to improve the flavour quality of Australian farmed barramundi through developing novel functional feeds. The project expects to expand our fundamental knowledge of flavour enhancement, whilst providing practical benefits with respect to final product quality. The project will enable industry to achieve higher product quality benchmarks, towards the ultimate goal of improving the marketability of barramundi both locally ....Flavour enhancing functional feeds for farmed Barramundi. This project aims to improve the flavour quality of Australian farmed barramundi through developing novel functional feeds. The project expects to expand our fundamental knowledge of flavour enhancement, whilst providing practical benefits with respect to final product quality. The project will enable industry to achieve higher product quality benchmarks, towards the ultimate goal of improving the marketability of barramundi both locally and overseas. This project will provide significant benefits to the Australian barramundi industry by increasing product values, thereby facilitating an economically sustainable growth of this important regional industry.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100014
Funder
Australian Research Council
Funding Amount
$4,996,503.00
Summary
ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resist ....ARC Research Hub for Supercharging Tropical Aquaculture Through Genetic Solutions. This project will deliver the genetic knowledge to instigate world-leading and highly productive breeding programs for five tropical aquaculture species (barramundi, pearl oyster, prawn, grouper and marine algae) in northern Australia. It will integrate cutting edge genetic and genomic approaches into innovative aquaculture enterprises and will establish a novel understanding of the genetic basis of disease resistance and how the production environment interfaces with the bacterial microbiome, pathogens and water quality to cause disease. Outcomes will lead to increased productivity, international competitiveness, and lowered disease risk and significantly expand Australia's capacity in the aquaculture sector.Read moreRead less
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of th ....Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of this complex inverse estuary system and its surrounding catchment. The new understanding of the sources, fluxes and fate of nutrients within the bay and the surrounding catchment, arising from this project, is expected to benefit management decision-making and establish a new standard in estuarine water quality investigation.Read moreRead less
Developing Robust Small Area Population Forecasts for Planning and Policy. This project aims to create more robust, detailed, and accurate small area population forecasts, and implement them in a sophisticated forecasting system for one jurisdiction in Australia, USA, UK and Canada. The project is significant as it expects to generate a suite of new and innovative methods, theory, and population forecasts that will be useful to researchers and planners both in Australia and overseas. Expected ou ....Developing Robust Small Area Population Forecasts for Planning and Policy. This project aims to create more robust, detailed, and accurate small area population forecasts, and implement them in a sophisticated forecasting system for one jurisdiction in Australia, USA, UK and Canada. The project is significant as it expects to generate a suite of new and innovative methods, theory, and population forecasts that will be useful to researchers and planners both in Australia and overseas. Expected outcomes include new forecasting methods, associated computer code, many open-access academic papers, and new international collaborations. More detailed and reliable population forecasts will bring substantial benefits to those planning our future infrastructure requirements (e.g. schools, hospitals, housing and transport).
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Industrial Transformation Training Centres - Grant ID: IC180100045
Funder
Australian Research Council
Funding Amount
$3,582,638.00
Summary
ARC Training Centre for Uniquely Australian Foods. The ARC Training Centre for Uniquely Australian Foods aims to provide a cohort of trained and industry-ready researchers who can lead the native foods industry forward. It plans to transform the native food and agribusiness sector, through the development of selected crops, foods and ingredients. The Centre will use an Indigenous governance group to oversee the process of converting traditional knowledge into branded products. Expected outcomes ....ARC Training Centre for Uniquely Australian Foods. The ARC Training Centre for Uniquely Australian Foods aims to provide a cohort of trained and industry-ready researchers who can lead the native foods industry forward. It plans to transform the native food and agribusiness sector, through the development of selected crops, foods and ingredients. The Centre will use an Indigenous governance group to oversee the process of converting traditional knowledge into branded products. Expected outcomes include technical information to support branding and market development, best practice development in social factors and legal arrangements for benefit sharing. This Centre will help drive sustainable growth of high-value products within the premium Australian food sector.
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The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecologic ....The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecological impacts of industry development. Important benefits of the project include information and tools for streamlining development approvals and accurately assessing risks to threatened species to improve outcomes for both our economy and our natural environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100278
Funder
Australian Research Council
Funding Amount
$370,000.00
Summary
Automating the smart home: an investigation of automated cooling practices. Home automation technologies are expected to achieve reductions in household energy costs and consumption. However, there has been no systematic investigation of the ways in which they are being incorporated into everyday life. The project aims to address this critical gap in relation to home cooling. It will investigate how automated cooling technologies are being incorporated into household practices in Australia, and ....Automating the smart home: an investigation of automated cooling practices. Home automation technologies are expected to achieve reductions in household energy costs and consumption. However, there has been no systematic investigation of the ways in which they are being incorporated into everyday life. The project aims to address this critical gap in relation to home cooling. It will investigate how automated cooling technologies are being incorporated into household practices in Australia, and the expectations they promote, sustain and transform. The project also aims to produce important new knowledge about how to study and understand the effects of ambient and automated technologies in everyday life and their potential impact on energy consumption.Read moreRead less