Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Integrating electrophysiology and molecular biology to understand the role of cell membranes in bacterial responses to chill and osmotic stress. Modern food manufacture is driven by competing demands: consumers prefer foods that are 'natural', i.e. having received minimal processing and containing less preservatives, and last, but are safe. Thus, a challenge is to find minimal sets of treatments and preservatives that limit microbial growth.
Current methods to for determining limits to microbi ....Integrating electrophysiology and molecular biology to understand the role of cell membranes in bacterial responses to chill and osmotic stress. Modern food manufacture is driven by competing demands: consumers prefer foods that are 'natural', i.e. having received minimal processing and containing less preservatives, and last, but are safe. Thus, a challenge is to find minimal sets of treatments and preservatives that limit microbial growth.
Current methods to for determining limits to microbial growth are time and consuming and empirical. We will assess the potential of a new method (MIFE) to rapidly measure limits of bacterial growth under combinations of treatments. At the same time we will study how cells, and in particular how the cell membrane, responds to these stresses to provide insights for the development of new, minimal - yet safe - food preservation technologies.
Read moreRead less
Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to ....Quantifying the impacts of environmental stress on marine microorganisms. Microorganisms underpin marine ecosystem health, yet there is limited understanding of how they will respond to different environmental pressures. This project will resolve this critical knowledge gap by developing a unique molecular platform for deriving quantitative stress thresholds for microbial communities inhabiting key reef habitats (seawater, sediments, invertebrates). Quantifying how reef microorganisms respond to a broad suite of environmental perturbations (temperature, nutrients, contaminants), will generate stress-response data that can be incorporated alongside eukaryotic data in environmental assessments, greatly improving the ecological relevance and reliability of risk and vulnerability assessments.Read moreRead less
Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management a ....Genetic architecture of species divergence and hybridisation in eucalypts. Eucalypts are an icon of Australia and are of great economic and ecological significance to the nation. They are the most widely planted hardwood trees in the world, but Australia is the centre of origin of most species and the custodian of this important native bioresource. Understanding the evolutionary processes that shape diversity in this internationally significant genus is important for its long-term management and conservation. This project links to large international initiatives currently underway for high-density mapping and sequencing of the eucalypt genome, to enhance the flow of information gained back to Australia for scientific, economic and environmental benefit.Read moreRead less
Evolutionary, macroecological and phylogenetic patterns in Australasian freshwater crayfish. This project connects Australian systematists to a worldwide project that involves all of the world's living experts on freshwater crayfish evolution in a coordinated effort to answer some very important evolutionary questions. It involves a group of invertebrate animals that are not only readily recognisable, but which in Australia includes the world's largest and the world's most terrestrial crayfish s ....Evolutionary, macroecological and phylogenetic patterns in Australasian freshwater crayfish. This project connects Australian systematists to a worldwide project that involves all of the world's living experts on freshwater crayfish evolution in a coordinated effort to answer some very important evolutionary questions. It involves a group of invertebrate animals that are not only readily recognisable, but which in Australia includes the world's largest and the world's most terrestrial crayfish species. Information gained from the project will contribute to the management of crayfish biodiversity, identification of threatened species and tools to identify these prominent and important members of Australian freshwater ecosystems.Read moreRead less
Climate-driven windblown dust and flood runoff can increase marine diseases by fungal pathogens. Determination of the role of fungal pathogens in marine disease outbreaks, and their linkages to climate-driven dust and flood events, have important applications for coastal fisheries and the Great Barrier Reef. This project will develop molecular tools and plankton recorder protocols to detect fungal outbreaks and assess ecosystem resilience.
Synthetic phenazines for enhanced biogas production from renewable and non-renewable resources. Methane (biogas) has a large role to play in meeting the energy needs of the human race globally whilst reducing greenhouse gas emissions. Microbial communities are responsible for biogas production from non-renewable (coal) and renewable (food waste) resources. This project seeks to: increase biogas yields by redirecting electron flow towards biogas producing microbes using electrochemically active p ....Synthetic phenazines for enhanced biogas production from renewable and non-renewable resources. Methane (biogas) has a large role to play in meeting the energy needs of the human race globally whilst reducing greenhouse gas emissions. Microbial communities are responsible for biogas production from non-renewable (coal) and renewable (food waste) resources. This project seeks to: increase biogas yields by redirecting electron flow towards biogas producing microbes using electrochemically active phenazines; understand the molecular mechanism by which phenazines increase biogas yields; and, assess the environmental consequence of phenazine application to coal seam gas production and anaerobic digestion of food waste. Phenazines are likely to emerge as a safe and cost-effective technology for improved biogas generation.Read moreRead less
Revealing Enigma of Salt Bladders to Help Crops Cope with Salinity. In this project, the key transport systems mediating salt sequestration in halophytes are planned to be characterised and linked with cell genetic and metabolic profiles. Salinity is a major environmental hurdle affecting crop production around the world. Halophytes (naturally salt-loving plants) use specialised structures, called salt bladders, to sequester excessive salt outside their metabolically active parts. This feature i ....Revealing Enigma of Salt Bladders to Help Crops Cope with Salinity. In this project, the key transport systems mediating salt sequestration in halophytes are planned to be characterised and linked with cell genetic and metabolic profiles. Salinity is a major environmental hurdle affecting crop production around the world. Halophytes (naturally salt-loving plants) use specialised structures, called salt bladders, to sequester excessive salt outside their metabolically active parts. This feature is not utilised by crops however, and no information is available about the molecular mechanisms by which salt is pumped into bladder cells. This knowledge will allow breeders to utilise this, previously unexplored, trait to improve crop performance under conditions of salinity.Read moreRead less
Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new know ....Macrophage control of mammalian growth and development. The immediate postnatal period in mammals is crucial for survival, long term health and productivity. This project is an international collaboration that aims to investigate how cells of the innate immune system called macrophages control somatic growth and development of mature organ function in the early postnatal period. The project aims to build upon investment in new animals models and a novel discovery to generate significant new knowledge that will challenge current concepts of mammalian growth control. The outcomes will enhance Australia's international reputation in the fields of physiology, immunology and developmental biology. Read moreRead less
How plants open up: revealing the evolution of stomatal opening mechanisms. This project aims to identify novel and conserved mechanisms that drive the opening of stomata – plant pores that enable CO2 acquisition for photosynthesis. Stomatal movements strongly affect plant productivity and water use efficiency and have profoundly influenced the earth’s climate and terrestrial ecology. This project will address critical gaps in our understanding of how plants open stomata in response to their env ....How plants open up: revealing the evolution of stomatal opening mechanisms. This project aims to identify novel and conserved mechanisms that drive the opening of stomata – plant pores that enable CO2 acquisition for photosynthesis. Stomatal movements strongly affect plant productivity and water use efficiency and have profoundly influenced the earth’s climate and terrestrial ecology. This project will address critical gaps in our understanding of how plants open stomata in response to their environment and the evolutionary history of the genes controlling this fundamental process. A major expected outcome is knowledge of the diversity of stomatal opening pathways, which should ultimately lead to improved predictions of plant responses to environmental change and assist future targeted modification of plant growth.Read moreRead less