Discovery Early Career Researcher Award - Grant ID: DE230100003
Funder
Australian Research Council
Funding Amount
$387,373.00
Summary
The evolution of venom and its role in shaping biodiversity. This project aims to study how venom, nature's most powerful weapon, evolves and shapes biodiversity. Using the iconic Australian and New Guinean venomous snakes as a model, this project expects to develop a novel approach to profile venom composition from museum specimens, test competing hypotheses on the evolution of venoms, and test for the association between the evolution of venoms and the evolution of diversity in species richnes ....The evolution of venom and its role in shaping biodiversity. This project aims to study how venom, nature's most powerful weapon, evolves and shapes biodiversity. Using the iconic Australian and New Guinean venomous snakes as a model, this project expects to develop a novel approach to profile venom composition from museum specimens, test competing hypotheses on the evolution of venoms, and test for the association between the evolution of venoms and the evolution of diversity in species richness and morphology. Expected outcomes include the largest venom database for any animal group and a better understanding of how venoms evolve and what role they play in earth’s biodiversity. The generated venom data has potential to be used in future studies to aid in the development of anti-venoms and drugs.Read moreRead less
Improving access to phylogenomic resources for under-resourced species: a new look at existing tools. This project will have an impact on our understanding of how to most effectively use existing genomic resources to benefit a wider range of species and to better design new genomic resources. By doing so, improved access to genomic resources will be provided to species that currently have few options.
Harmonic analysis of rough oscillations. This project intends to explore new perspectives in harmonic analysis. Harmonic analysis is a set of mathematical techniques used in many branches of science and engineering to analyse complex signals (functions). It is highly effective in modelling phenomena such as the propagation of electromagnetic waves, but it is currently limited to propagation occurring in a simple-enough medium. An intense international research effort in harmonic analysis is curr ....Harmonic analysis of rough oscillations. This project intends to explore new perspectives in harmonic analysis. Harmonic analysis is a set of mathematical techniques used in many branches of science and engineering to analyse complex signals (functions). It is highly effective in modelling phenomena such as the propagation of electromagnetic waves, but it is currently limited to propagation occurring in a simple-enough medium. An intense international research effort in harmonic analysis is currently under way to lift this limitation. This project is part of that effort, and aims to unite two of its fundamental directions of development: one focusing on the roughness of the medium; and one focusing on the interaction between highly oscillatory aspects of the function and the geometry of the medium.Read moreRead less
ARC Financial Integrity Research Network. The integrity of the financial system is constantly under stress because of the development of ever more complex financial instruments, structures and strategies, and the associated research technologies that continues to accelerate worldwide. FIRN's vision is to harness the considerable strengths of Australia's internationally renowned finance, accounting and economics researchers into a research agenda to address issues concerning the integrity of the ....ARC Financial Integrity Research Network. The integrity of the financial system is constantly under stress because of the development of ever more complex financial instruments, structures and strategies, and the associated research technologies that continues to accelerate worldwide. FIRN's vision is to harness the considerable strengths of Australia's internationally renowned finance, accounting and economics researchers into a research agenda to address issues concerning the integrity of the financial system. It will enable Australian research in this area to match the scale and impact of similar research in other major international financial centres, and play an essential role in placing Australia among the world's leaders in financial markets related research.Read moreRead less
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Investment Approaches and Applications in Financial Markets: Evolutionary Kernel Based Subset Time-Series Using Semi-Parametric Approaches. The project will develop new investment assessments based on subset time-series modeling. Innovative evolutionary kernel smoothing algorithms using semi-parametric approaches will be introduced. The project will make three important applications of this modeling in financial markets: a) benchmarking and evaluation of inflation-indexed bonds; b) evaluation of ....Investment Approaches and Applications in Financial Markets: Evolutionary Kernel Based Subset Time-Series Using Semi-Parametric Approaches. The project will develop new investment assessments based on subset time-series modeling. Innovative evolutionary kernel smoothing algorithms using semi-parametric approaches will be introduced. The project will make three important applications of this modeling in financial markets: a) benchmarking and evaluation of inflation-indexed bonds; b) evaluation of the performance of global diversified investment funds; and c) prediction to provide early warning of the emergence of destabilising deflation or inflation. These three applications will lead to improved risk management practices and investment performance. Recursive algorithms will provide new statistical methods to study investment asset price movements and market volatility.
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Helping Central Banks Measure Unobserved Variables Using Real-time Forecasts. The project addresses structural measurement problems confronted routinely by central bankers. The techniques developed, and the estimates provided, will aid directly the Partner Organisations (the Reserve Bank of Australia, the Reserve Bank of New Zealand and Norges Bank) and other central banks in formulating monetary policy. The analysis will allow interest rates in Australia and elsewhere to be set with greater pre ....Helping Central Banks Measure Unobserved Variables Using Real-time Forecasts. The project addresses structural measurement problems confronted routinely by central bankers. The techniques developed, and the estimates provided, will aid directly the Partner Organisations (the Reserve Bank of Australia, the Reserve Bank of New Zealand and Norges Bank) and other central banks in formulating monetary policy. The analysis will allow interest rates in Australia and elsewhere to be set with greater precision. The techniques developed in this project will facilitate the understanding and communication of monetary policy within the central banks concerned, and enhance communication of monetary policy strategy to the public.Read moreRead less
Investment approaches and opportunities in renewable energy and financial resource markets, using semi-parametric approaches to evolutionary subset time-series lattice-ladder modelling. The project findings will help Australian exporters and importers understand and manage energy and resource price risks more effectively. The investment community will benefit through selecting optimal asset allocations and enhancing value to investors. It will also benefit many other agencies, particularly in th ....Investment approaches and opportunities in renewable energy and financial resource markets, using semi-parametric approaches to evolutionary subset time-series lattice-ladder modelling. The project findings will help Australian exporters and importers understand and manage energy and resource price risks more effectively. The investment community will benefit through selecting optimal asset allocations and enhancing value to investors. It will also benefit many other agencies, particularly in the service industries. It is not well recognised that in developed countries, including Australia, the financial service and related sectors account for more than 60 percent of economic activity and employment, so it is critical that more sophisticated statistical methods be established, and practical applications conducted, in order to advance the understanding of complexity management in the financial service and related sectors.Read moreRead less
Special Research Initiatives - Grant ID: SR0354466
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Mathematics in Contemporary Science. The Mathematics in Contemporary Science Research Network brings contemporary methods of non-linear analysis and differential equations, geometric reasoning and relevant algebraic and topological ideas to enrich six application areas in modern science: Complex Systems, Computer Vision, Optimal Transportation, Nanotechnology, Physics and Shortest Networks. MiCS will develop both the mathematics and the application areas in parallel. It will focus on postgradu ....Mathematics in Contemporary Science. The Mathematics in Contemporary Science Research Network brings contemporary methods of non-linear analysis and differential equations, geometric reasoning and relevant algebraic and topological ideas to enrich six application areas in modern science: Complex Systems, Computer Vision, Optimal Transportation, Nanotechnology, Physics and Shortest Networks. MiCS will develop both the mathematics and the application areas in parallel. It will focus on postgraduate training through workshops, summer schools and web based resources and build long-term international collaborations with EU networks and NSERC, NSF and EPSRC institutes as well as bringing together academic and industry leaders.Read moreRead less
Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less