Ubiquitin And SUMO DNA Damage Response Signalling At Deprotected Telomeres During The Cell Cycle
Funder
National Health and Medical Research Council
Funding Amount
$302,627.00
Summary
Following genome damage cells stop the cell division process and initiate DNA repair. We discovered that at specific times during cell division his does not happen if the damage signals originate from the chromosome ends (i.e. “telomeres”). We anticipate this is necessary to prevent genomic instability in healthy cells and may be driving genomic instability in cancer cells. Experiments described here will elucidate the molecular mechanisms and biological significance of our observation.
The Role Of Nuclear Architecture In The DNA Damage Response
Funder
National Health and Medical Research Council
Funding Amount
$561,966.00
Summary
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
How Replication Stress Activates The Mitotic Telomere DNA Damage Response To Kill Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$486,467.00
Summary
We discovered a novel mechanism linking stress during DNA replication to difficulties with the cell division process, and identified how this turns on DNA damage response signals from the chromosome ends (i.e. “telomeres”). We have further identified that we can exploit this mechanism to kill cancer cells. In this project we will explore this newly discovered mechanism and identify how it can be targeted for therapeutic purposes.
Discovery Early Career Researcher Award - Grant ID: DE160101020
Funder
Australian Research Council
Funding Amount
$350,821.00
Summary
The geodynamics of past sea level changes. This project is designed to quantify the effect of flow deep within Earth’s interior on past sea-level changes and on the flooding history of Australia over the last 550 million years. The rise and fall of sea level has shaped our planet over time. This project plans to combine recent advances in tectonic reconstructions and dynamic Earth models with the global and Australian rock record. The intended outcome is to understand how the Earth’s surface is ....The geodynamics of past sea level changes. This project is designed to quantify the effect of flow deep within Earth’s interior on past sea-level changes and on the flooding history of Australia over the last 550 million years. The rise and fall of sea level has shaped our planet over time. This project plans to combine recent advances in tectonic reconstructions and dynamic Earth models with the global and Australian rock record. The intended outcome is to understand how the Earth’s surface is shaped by flow within its interior, and how these processes explain the sedimentary record. Project results have the potential to be used as an exploration tool to maximise Australia’s competitive advantage in exploring onshore sedimentary basins.Read moreRead less
Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entir ....Longshore Sediment Supply to the Deep Ocean. The current model to supply sand to deep water off continental margins is that provided by rivers operating at low sea level. We propose an alternative model in which sand is provided by longshore transport to deep water at high sea level north of Fraser Island, SE Queensland. Here we will test the validity of our new model by site studies of sea bottom morphology, composition and dynamics. If the model proves true, we will have: 1) generated an entirely new exploration model for deepwater hydrocarbons, 2) provided new expertise and seabed maps for generating a superior marine naval defence capability.Read moreRead less
A one million year record of relative sea-level, climatic and environmental changes - Aeolianites of the southern Australian continental margin. This project will (1) further refine two dating methods that will revolutionize Australia's capacity to date geological and archaeological events; (2) ensure that Australia remains in the forefront in applied geochronology and that a sufficient level of technical expertise remains within the country; (3) examine the sensitivity of coastal environments t ....A one million year record of relative sea-level, climatic and environmental changes - Aeolianites of the southern Australian continental margin. This project will (1) further refine two dating methods that will revolutionize Australia's capacity to date geological and archaeological events; (2) ensure that Australia remains in the forefront in applied geochronology and that a sufficient level of technical expertise remains within the country; (3) examine the sensitivity of coastal environments to rapid climate and sea-level changes; (4) increase public awareness of the scientific basis for the unique nature of Australia's coastal landscapes; and (5) may also assist in the exploration of strategically important minerals. Read moreRead less
Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students train ....Kinematica: Inference-Based Rapid Resource Exploration Scenario Testing. This project aims to build a new workflow for improving resource exploration evaluation by Australian companies and applied to three practical industry cases in frontier basins. The expected outcomes of this proposal are: detailed risk analysis of oil and gas prospectivity in frontier basins onshore and offshore Australia; a new strategic collaboration between Australian industry, government and universities; students trained in advanced computational methods suitable for the evolving Australian oil and gas industry; and a software product that has high commericalisation potential. The project will transfer knowledge from European industry and universities to Australia and has applications for mineral prospectivity in sedimentary basins. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882854
Funder
Australian Research Council
Funding Amount
$6,000,000.00
Summary
Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shapin ....Australian Membership of the Integrated Ocean Drilling Program. Membership of the Integrated Ocean Drilling Program (IODP) will provide high-leverage access to the largest, and most effective international geoscience program.
Results from drilling within Australia's marine jurisdiction will give understanding of the oceans' state under past climates through high resolution records of the range of oceanographic and biological responses to climate change, the role of the deep biosphere in shaping oil and gas deposits, hydrothermal and igneous processes involved in ore genesis, and enhanced understanding of some of the world's largest earthquake- and tsunami-generating processes.
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Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
A palaeoenvironmental reconstruction of Holocene coastal valley evolution in NSW: A magnetic, geochemical, sedimentological and microfossil investigation. Coastal environments are a critical interface between land and ocean. They are sensitive to sea level change and they can influence climate because they trap a large fraction of the carbon buried annually in the oceans. We propose an inter-disciplinary investigation to determine how NSW coastal environments responded to past climate change. Th ....A palaeoenvironmental reconstruction of Holocene coastal valley evolution in NSW: A magnetic, geochemical, sedimentological and microfossil investigation. Coastal environments are a critical interface between land and ocean. They are sensitive to sea level change and they can influence climate because they trap a large fraction of the carbon buried annually in the oceans. We propose an inter-disciplinary investigation to determine how NSW coastal environments responded to past climate change. This will help to understand factors such as flood chronologies and acid sulphate soil potential and to predict the response to these environments to future climate change. Coastal environments support an increasing global population that will benefit from a better understanding of processes and responses within this critical zone.Read moreRead less