Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Is SPINT1 a key regulator of placental development? . The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion o ....Is SPINT1 a key regulator of placental development? . The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion of the placental exchange interface which is critical for offspring survival.
The project will increase understanding of placental development, enhance collaboration and research knowhow, and promote future applied projects in all species that reproduce via placental support.Read moreRead less
The role of synapse development in cognitive disorder. In humans, intellectual disability occurs when nerve cells in the brain fail to connect. The project examines fundamental molecular processes involved in synapse development of neurons. The use of insect models provides a generalised biological template to understand how synaptic molecules contribute to behaviours that underlie cognitive disorder.
An active approach to detect and defend against peer-to-peer botnets. The aim of this project is to develop an effective defence system to help organisations detect and defend against the peer-to-peer (P2P) botnets. If this research is accomplished successfully, it will be a big step forward in defeating this new but devastating malicious software widely utilised by Internet criminals and terrorists. The capability of a nation to defend against the P2P botnet attacks on its information infrastru ....An active approach to detect and defend against peer-to-peer botnets. The aim of this project is to develop an effective defence system to help organisations detect and defend against the peer-to-peer (P2P) botnets. If this research is accomplished successfully, it will be a big step forward in defeating this new but devastating malicious software widely utilised by Internet criminals and terrorists. The capability of a nation to defend against the P2P botnet attacks on its information infrastructure is central to the control of such attacks and hence to a nation's long-term survival and prosperity. The outcomes of this project can be directly used in Australian research communities and adopted by industry and government agencies.Read moreRead less
Dynamics and correlations of many-body systems. The proposed program will greatly enhance Australian science through linking innovative
theoretical techniques with the successful ongoing Australian experimental program in atom
lasers, atom chip interferometry and ultra-cold fermions. Pioneering theoretical methods in
quantum phase-space are internationally recognized, and will be extended into new areas relevant
to Australia. These have fundamental significance to fields ranging from nanotec ....Dynamics and correlations of many-body systems. The proposed program will greatly enhance Australian science through linking innovative
theoretical techniques with the successful ongoing Australian experimental program in atom
lasers, atom chip interferometry and ultra-cold fermions. Pioneering theoretical methods in
quantum phase-space are internationally recognized, and will be extended into new areas relevant
to Australia. These have fundamental significance to fields ranging from nanotechnology to
astrophysics, as well as providing a route to improved atomic clocks and other instruments.
Combining these theoretical and computational methods from the physical sciences with biology
and genetics will provide future cross-disciplinary benefits to Australian biomedical science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882531
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Quantum Limited Single Atom Detectors. The technology that has shaped our society, solid state diodes, transistors and computer chips is based on our ability to manipulate the average quantum properties of materials such as semiconductors. This physics has been well understood for decades. Many technologies that will shape our societies in this century will be based on our ability to manipulate quantum systems precisely, an area that is the focus of quantum atom optics. The detectors requested i ....Quantum Limited Single Atom Detectors. The technology that has shaped our society, solid state diodes, transistors and computer chips is based on our ability to manipulate the average quantum properties of materials such as semiconductors. This physics has been well understood for decades. Many technologies that will shape our societies in this century will be based on our ability to manipulate quantum systems precisely, an area that is the focus of quantum atom optics. The detectors requested in this proposal will ensure that Australia remains competitive in the technologies that will emerge from the new field of quantum atom optics.Read moreRead less
Assessing the physiological roles of ubiquitination in regulating neuronal ion channels, receptors and transporters. Significant alterations in the activity neuronal transporters and receptors occur during tissue injury and regeneration as well as in many neurodegenerative disease states. Modulation of the pathways that control these transporters is an emerging therapeutic target, however, the molecular basis of these control mechanisms remain poorly understood. The outcome of this project will ....Assessing the physiological roles of ubiquitination in regulating neuronal ion channels, receptors and transporters. Significant alterations in the activity neuronal transporters and receptors occur during tissue injury and regeneration as well as in many neurodegenerative disease states. Modulation of the pathways that control these transporters is an emerging therapeutic target, however, the molecular basis of these control mechanisms remain poorly understood. The outcome of this project will be a thorough characterisation of a novel regulatory paradigm in neurons that is likely to be crucial for neuronal development and regeneration, and will potentially provide novel therapeutic targets for various neuronal diseases.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101075
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Novel immune cell subsets in the centre nervous system and supporting tissues. This project aims to identify and characterise novel resident immune cell subsets within the brain and retina, and their close supporting tissues. The project expects to generate new knowledge in the areas of neuroimmunology and ocular immunology by using molecular and cellular techniques to examine the diversity of immune cells within the brain and retina. It is expected that the project will advance our understandin ....Novel immune cell subsets in the centre nervous system and supporting tissues. This project aims to identify and characterise novel resident immune cell subsets within the brain and retina, and their close supporting tissues. The project expects to generate new knowledge in the areas of neuroimmunology and ocular immunology by using molecular and cellular techniques to examine the diversity of immune cells within the brain and retina. It is expected that the project will advance our understanding of the biological mechanisms that protect the central nervous system from harmful inflammation and thus improve our knowledge of the immunobiology of the brain and eye.Read moreRead less