Identifying The Pathological Mechanism Of PCDH19-Girls Clustering Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$523,988.00
Summary
Changes in the PCDH19 gene are a relatively common cause of epilepsy. To better understand the basis of this disorder, we have developed unique mouse models that mimic the genetic changes and symptoms of this condition. We will perform careful analysis of brain development in these models to determine the primary cause of this condition. These experiments will create greater understanding of how changes in PCDH19 cause epilepsy in girls and facilitate the development of new treatments.
Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
Testing Novel Therapies Using Paediatric Brain Tumour Models
Funder
National Health and Medical Research Council
Funding Amount
$384,023.00
Summary
Brain tumours are the second most common childhood cancer, with 300 children affected in Australia each year. Many children with brain tumours continue to die of their disease, whilst survivors are often left with devastating life long side effects. Our goals are to harness the power of innovative model systems of childhood brain tumours, in order to test the effectiveness of new treatments for these devastating diseases, so that the most promising therapies can be taken through to the clinic.
Gene Mining For Novel Molecular Determinants Of The Skeleton
Funder
National Health and Medical Research Council
Funding Amount
$633,447.00
Summary
Musculoskeletal conditions affect over 6 million Australians and research has shown that genetic background strongly influences development of these disorders. This project will identify genes that have a role in controlling bone and joint architecture. Identification of these genes will assist in the development of treatments targeting bone disorders and allow screening for these genes to provide an opportunity for people to take preventative action to improve bone and joint health.
The Social Production of Science in Antarctica: A Study of Davis Station. Antarctica is a unique scientific laboratory. It is the only continent historically uninhabited by humans; access to its vast land and ice-scapes, and its surrounding oceans, is today almost exclusively reserved for scientists. Although these 'Antarcticans' represent multiple disciplines, and pursue a wide variety of research agendas, their shared experiences of working on the continent, and their shared professional netwo ....The Social Production of Science in Antarctica: A Study of Davis Station. Antarctica is a unique scientific laboratory. It is the only continent historically uninhabited by humans; access to its vast land and ice-scapes, and its surrounding oceans, is today almost exclusively reserved for scientists. Although these 'Antarcticans' represent multiple disciplines, and pursue a wide variety of research agendas, their shared experiences of working on the continent, and their shared professional networks, mean that they constitute a distinct community of practice. However, this community has yet to be subjected to detailed ethnographic enquiry. This project aims to examine Antarctic scientists' research practices, and their cultures of knowledge production, through an ethnographic study of Australia's Davis Station.Read moreRead less
Quantifying and parameterising ocean mixing. This project aims to advance our ability to describe the efficiency and intensity of ocean mixing. The project will develop and apply innovative techniques to estimate ocean mixing from both traditional ship-based, vertical-profiling turbulence measurements and from autonomous moorings. The project will undertake a re-analysis of historic measurements and obtain new measurements using autonomous systems. The results will be used to develop both a uni ....Quantifying and parameterising ocean mixing. This project aims to advance our ability to describe the efficiency and intensity of ocean mixing. The project will develop and apply innovative techniques to estimate ocean mixing from both traditional ship-based, vertical-profiling turbulence measurements and from autonomous moorings. The project will undertake a re-analysis of historic measurements and obtain new measurements using autonomous systems. The results will be used to develop both a universal relationship describing the efficiency of ocean mixing, and to quantify the underlying length scale controlling mixing intensity. This will enable the development of the next generation of turbulence closure models needed to describe ocean circulation and stirring.Read moreRead less
Wave dynamics in topographically-complex coastal reef systems. Both tropical coral and temperate rocky reefs are abundant features of Australia's coastline, yet their hydrodynamics (waves, currents and water levels) are poorly understood relative to other coastal environments such as beaches. This project will elucidate the complex hydrodynamic processes when waves interact with the steep-slopes and large bottom roughness of reefs, by establishing an international research program combining labo ....Wave dynamics in topographically-complex coastal reef systems. Both tropical coral and temperate rocky reefs are abundant features of Australia's coastline, yet their hydrodynamics (waves, currents and water levels) are poorly understood relative to other coastal environments such as beaches. This project will elucidate the complex hydrodynamic processes when waves interact with the steep-slopes and large bottom roughness of reefs, by establishing an international research program combining laboratory and field measurements with numerical modelling. The improved process-understanding of reef hydrodynamics developed through this project will lead to significant advances in our ability to predict the impacts of extreme events (for example, storms and tsunamis) and climate change on coasts, both here and abroad.Read moreRead less
Indian Ocean Climate Change: Ningaloo Reef, a litmus test for the survival of coral reefs. Coral reefs are at the frontline from the effects of rapidly rising levels of carbon dioxide that is causing both global warming and oceans to become more acid-like. Our research program will determine how the survival of one of the World’s most pristine and best preserved coral reefs, Ningaloo Reef, is linked to the response of Australia’s Indian Ocean to climate change. For the first time, we will simula ....Indian Ocean Climate Change: Ningaloo Reef, a litmus test for the survival of coral reefs. Coral reefs are at the frontline from the effects of rapidly rising levels of carbon dioxide that is causing both global warming and oceans to become more acid-like. Our research program will determine how the survival of one of the World’s most pristine and best preserved coral reefs, Ningaloo Reef, is linked to the response of Australia’s Indian Ocean to climate change. For the first time, we will simulate realistic ‘future’ conditions and see how actual coral reef systems respond. This will provide a ‘yardstick’ against which the best-case survival potential of the world’s coral reefs can be assessed, critical for underpinning the urgently needed action to reduce greenhouse gas emissions if we are to ensure the survival of coral reefs.Read moreRead less
Physical processes in complex coastal reef environments: the dynamics of wave- and tide-dominated systems. Coastal reefs are ubiquitous features of Australia's coastline, yet the dynamics controlling water motion on reefs still remain poorly understood. This project will significantly advance our understanding of coastal processes within reef environments, thus improving predictions of the impacts of extreme storms and climate change on our coasts.
FINANCIAL (IN)SECURITY IN LATER LIFE: WOMEN, WORK , SUPERANNUATION AND AUSTRALIA'S RETIREMENT INCOME SYSTEM. An ageing population is expected to contribute to significant demographic, social and labour market shifts, which, together with fiscal stresses, will affect the future mix of state and private retirement income provisions. However, gender-based issues associated with these changes remain under-researched. Using a life-course approach qualitative methodologies will be used to explore inte ....FINANCIAL (IN)SECURITY IN LATER LIFE: WOMEN, WORK , SUPERANNUATION AND AUSTRALIA'S RETIREMENT INCOME SYSTEM. An ageing population is expected to contribute to significant demographic, social and labour market shifts, which, together with fiscal stresses, will affect the future mix of state and private retirement income provisions. However, gender-based issues associated with these changes remain under-researched. Using a life-course approach qualitative methodologies will be used to explore inter-relationships between: women's workforce participation, education, marital status, fertility, financial literacy; retirement incomes;concessions, benefits; and women's economic security in later years. The research will make a significant contribution to the development and implementation of retirement income policy and the debate on gender equity in the labour market. Read moreRead less