The Effects Of Estrogen-Responsive B Box Protein On Retinoid Sensitivity In Cancer And Its Significance In Development
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
Although effective, many cancer drugs often lead to side effects, especially in children. New therapies are needed that specifically target cancer cells while leaving normal cells unaffected. I am studying a novel protein (EBBP) which I believe has an important role in cancer cell growth. By studying EBBP I aim to be able to increase the effectiveness of the low toxic chemotherapy retinoic acid without increased side effects, as well as understand the functional role of EBBP in cancer cells.
Targeting PI3K-regulated Small Non-coding RNAs To Restore Cardiac Function
Funder
National Health and Medical Research Council
Funding Amount
$610,204.00
Summary
Heart failure affects approximately 2.4% of the adult population and over 11% of people over 80 years old. The majority of existing therapies slow, rather than reverse heart failure progression. The primary goal of this study is to determine whether regulating novel regulatory genes can enhance cardiac function in a setting of heart failure. Ultimately, technologies that target these genes may lead to innovative pharmacotherapies in the clinical management of heart failure.
Discovery Early Career Researcher Award - Grant ID: DE190100113
Funder
Australian Research Council
Funding Amount
$420,437.00
Summary
Interactions between volumetric units in modular buildings. This project aims to develop an in-depth understanding of the interactions between volumetric units in modular buildings to develop integration strategies for the interconnection of modules. The uptake of modular construction has been hindered by the technical complexities of the design process for manufacture and assembly, in particular the flexible connection of services. By addressing significant gaps in the guidance on the design of ....Interactions between volumetric units in modular buildings. This project aims to develop an in-depth understanding of the interactions between volumetric units in modular buildings to develop integration strategies for the interconnection of modules. The uptake of modular construction has been hindered by the technical complexities of the design process for manufacture and assembly, in particular the flexible connection of services. By addressing significant gaps in the guidance on the design of modular interconnections and their integration strategies, this project expects to enhance the industry’s capacity to adopt safe, economical and standardised designs of modular systems. This project should significantly reduce the risk in decision making in modular construction, and transformation to advanced building manufacturing technologies in Australia and beyond.Read moreRead less
Special Research Initiatives - Grant ID: SR140100001
Funder
Australian Research Council
Funding Amount
$35,000,000.00
Summary
The Juvenile Diabetes Research Foundation Australian Type 1 Diabetes Research Network and Program. This Proposal continues the development of the initial Type 1 Diabetes Clinical Research Network (CRN), launched by JDRF in June 2011 with a $5m grant from the Australian Government.
The principal goal of the CRN is to positively impact the life of people with T1D in Australia through the support and promotion of clinical research. A further electoral commitment of $35m over 5 years will enable f ....The Juvenile Diabetes Research Foundation Australian Type 1 Diabetes Research Network and Program. This Proposal continues the development of the initial Type 1 Diabetes Clinical Research Network (CRN), launched by JDRF in June 2011 with a $5m grant from the Australian Government.
The principal goal of the CRN is to positively impact the life of people with T1D in Australia through the support and promotion of clinical research. A further electoral commitment of $35m over 5 years will enable further progress towards finding a cure for T1D, including delivering better and faster access to new therapies and treatments that can help prevent and manage the disease.
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International Trade Policy and the Dynamics of Open Economies. The project is concerned with the relationship between an open economy's international trading conditions and the allocation of resources within the economy, particularly over time (dynamic effects). The trading conditions reflect international markets and governments' trade policies. The dynamic effects upon the economy include the rate of growth, saving and inter-generation welfare. The models developed to study these relationship ....International Trade Policy and the Dynamics of Open Economies. The project is concerned with the relationship between an open economy's international trading conditions and the allocation of resources within the economy, particularly over time (dynamic effects). The trading conditions reflect international markets and governments' trade policies. The dynamic effects upon the economy include the rate of growth, saving and inter-generation welfare. The models developed to study these relationships will link international markets with domestic and future markets in a unified and consistent manner. The outcomes include a better theoretical understanding of these relationships and empirical inter-temporal models for the Australian economy that permit measurement of these dynamic effects.Read moreRead less
Real-time imaging of the initiation of adaptive immunity in vivo. Understanding the first few hours of an immune response is fundamental to understanding how the human immune system functions. The immune system mounts our responses to infectious diseases, but can also cause autoimmune disease, allergy, and organ graft rejection. We will study how naive antigen-specific T cells first contact antigen in lymph nodes using 2-photon intravital microscopy. The research has the potential to change the ....Real-time imaging of the initiation of adaptive immunity in vivo. Understanding the first few hours of an immune response is fundamental to understanding how the human immune system functions. The immune system mounts our responses to infectious diseases, but can also cause autoimmune disease, allergy, and organ graft rejection. We will study how naive antigen-specific T cells first contact antigen in lymph nodes using 2-photon intravital microscopy. The research has the potential to change the way we think about the clonal selection of lymphocytes, the fundamental theory underlying our understanding of the immune system.Read moreRead less
Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to pred ....Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to predict the ocean state on timescales of days to decades. This is expected to yield efficiencies in shipping, marine search and rescue and naval operations, and increase the accuracy of projected future changes in climate, sea level, ocean ecosystems and the cryosphere.Read moreRead less
Understanding the survival of forests under drought . Droughts are predicted to become more extreme in the near future, with potentially devastating impacts on Australian forest ecosystems. This project aims to address key knowledge gaps in our understanding of how plants tolerate extreme drought stress and utilise this new knowledge to improve vegetation models suitable for assessing ecosystem vulnerability. We will use innovative experimental methodology to determine the processes by which wat ....Understanding the survival of forests under drought . Droughts are predicted to become more extreme in the near future, with potentially devastating impacts on Australian forest ecosystems. This project aims to address key knowledge gaps in our understanding of how plants tolerate extreme drought stress and utilise this new knowledge to improve vegetation models suitable for assessing ecosystem vulnerability. We will use innovative experimental methodology to determine the processes by which water transport breaks down in roots, stems and leaves and the mechanisms governing recovery from severe drought stress. The project will provide a deeper understanding of drought tolerance in trees, improved forecasting of risks to native vegetation, and enhanced management of native forest resources. Read moreRead less
Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilit ....Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilities, and released for community use. These developments underpin future ocean state forecasts, sea ice forecasts, wave forecasts, decadal climate prediction and climate process studies. The project will benefit search and rescue, Defence and shipping operations, and will enhance future climate projections.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101654
Funder
Australian Research Council
Funding Amount
$335,528.00
Summary
Assessing Eucalyptus forest responses to rising CO2 and climate change. Rising atmospheric CO2 and the associated changes in rainfall regimes are rapidly reshaping how Australia’s forest ecosystems function and underpin our daily life. Whether Australia’s native Eucalyptus trees can withstand the impacts of climate extremes such as drought and heat under rising CO2 is a crucial question that this project aims to resolve. Using an innovative framework that integrates novel knowledge, data assimil ....Assessing Eucalyptus forest responses to rising CO2 and climate change. Rising atmospheric CO2 and the associated changes in rainfall regimes are rapidly reshaping how Australia’s forest ecosystems function and underpin our daily life. Whether Australia’s native Eucalyptus trees can withstand the impacts of climate extremes such as drought and heat under rising CO2 is a crucial question that this project aims to resolve. Using an innovative framework that integrates novel knowledge, data assimilation and ecosystem modelling, this project will provide critically needed evidence to disentangle the multifaceted impacts of climate change to Eucalyptus trees. This will help reduce the predictive uncertainty in assessing the vulnerability and resilience of Eucalyptus forests in the changing Australian landscape. Read moreRead less