We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100062
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Universal Optical Transmitter for rapid prototyping and system emulation. Universal optical transmitter for rapid prototyping and system emulation: This Project proposes an integrated, multi-user facility for the generation of extremely wide-bandwidth optical communication signals that will help to dramatically improve the data-handling capability of optical fibres and improve the energy efficiency of optical communication networks. The project will modulate the input of an advanced optical tran ....Universal Optical Transmitter for rapid prototyping and system emulation. Universal optical transmitter for rapid prototyping and system emulation: This Project proposes an integrated, multi-user facility for the generation of extremely wide-bandwidth optical communication signals that will help to dramatically improve the data-handling capability of optical fibres and improve the energy efficiency of optical communication networks. The project will modulate the input of an advanced optical transmitter with multi-level, multi-phase signals at multi-Gb/s rates to generate 'higher-order' modulation formats at multi- terra bits per second rates including orthogonal frequency-division multiplexing (OFDM), Nyquist-wavelength-division multiplexing (WDM), regular WDM and Optical Time-Division Multiplexing (OTDM). With this transmitter the project will investigate advanced optical communications concepts including 'constellations' of phase and intensity, limitations of nonlinearity in optical fibres, signal regeneration, and all-optical routing.Read moreRead less
Understanding The Acute And Cumulative Metabolic Effects Of Prolonged Sitting In Adults
Funder
National Health and Medical Research Council
Funding Amount
$416,597.00
Summary
Sedentary behaviour (sitting time) has been linked to an increased risk of chronic illnesses, including type 2 diabetes and obesity, but recent evidence suggests that light-intensity activity (non-exercise activities of daily living) is associated with reduced risk. These studies will examine whether breaking up sitting time with frequent short periods of activity can overcome the negative effects of prolonged sitting on blood glucose and blood fats in overweight older adults.