Using Conversational Computer Technology To Improve Diabetes Management: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$708,606.00
Summary
The diabetes epidemic is a growing challenge for the Australian health care system with over 1 million Australians living with diabetes. The impact on individuals' lives and the whole of Australian society is very substantial indeed. There is very good evidence that this impact would be reduced by developing new approaches to manage the disease and facilitate improved self-management. Recent developments in information and communications technologies offer some promising new ways and tools for a ....The diabetes epidemic is a growing challenge for the Australian health care system with over 1 million Australians living with diabetes. The impact on individuals' lives and the whole of Australian society is very substantial indeed. There is very good evidence that this impact would be reduced by developing new approaches to manage the disease and facilitate improved self-management. Recent developments in information and communications technologies offer some promising new ways and tools for achieving this. This research will evaluate a computer-controlled, interactive telephone system for improving the management and self-management of Type 2 diabetes in addition to routine care. Patients with Type 2 diabetes will be recruited from Brisbane and each patient will be randomly assigned to receive either this new program or just their usual care from their doctor or Diabetes Clinic. The first group will call the system weekly for six months using a regular phone or a mobile phone if they wish. During the call, they will answer questions by speaking into the phone, listen to feedback and strategies for improving management of their diabetes and then discuss their next targets and behavioural actions. They will receive systematic and tailored advice on blood glucose testing, nutrition and physical activity, as well as medication taking and foot care. The system individualises conversations according to the user s answers and responses over all the interactive sessions. The trial will formally evaluate the clinical impact on blood glucose control and the adoption and maintenance of the targeted health habits, as well as the intervention s cost-effectiveness and users satisfaction with the system. This project s significance lies in the excellent potential of using this new technology to provide a 'low cost' but effective program to help people better manage Type 2 diabetes.Read moreRead less
Which Mental Activities And When For Dementia Prevention? The Four Nations Longitudinal Collaboration
Funder
National Health and Medical Research Council
Funding Amount
$183,218.00
Summary
We will examine the link between lifetime participation in complex mental activities and long term dementia risk in a level of detail not previously possible. Four major studies of brain health from around the world will join forces for the first time to determine which mental activities are most closely linked to protection from dementia, and when during the lifespan these are most important. Mental activity will be assessed using our recently published Lifetime of Experiences Questionnaire.
TELEPHONE COUNSELLING FOR MAINTENANCE OF PHYSICAL ACTIVITY, WEIGHT LOSS And GLYCAEMIC CONTROL IN TYPE 2 DIABETES
Funder
National Health and Medical Research Council
Funding Amount
$1,285,894.00
Summary
Regular exercise, a healthy diet and weight loss are key to managing type 2 diabetes, yet these are major challenges for most people with diabetes. This study will evaluate the impact of a telephone counselling program to assist people with type 2 diabetes to exercise, eat a healthy diet and lose weight, with the goal of helping them to sustain these changes over the long-term. It is expected that these lifestyle changes will also result in improved blood glucose control and quality of life.
A reduced capacity to recover balance following an imbalance episode contributes to the high incidence of falls in older adults. The goal of the present study is to determine how age-related differences in lower extremity neuromuscular and biomechanical properties are related to balance recovery capacity and falls incidence. A detailed understanding of this relationship is necessary for the development of efficacious exercise-based interventions for the prevention of falls.
Tough bio-derived and biodegradable wood plastic composites. This project aims for the development of tough bio-based and biodegradable wood plastic composites (WPCs), directly addressing a key end-user demand that performance of bio-WPCs must be at least comparable with existing commercial WPCs. The project expects to generate key innovations such as developing a new, high performance, bio-based and biodegradable WPC by incorporating native spinifex-derived nano-cellulose fibres, ensuring excel ....Tough bio-derived and biodegradable wood plastic composites. This project aims for the development of tough bio-based and biodegradable wood plastic composites (WPCs), directly addressing a key end-user demand that performance of bio-WPCs must be at least comparable with existing commercial WPCs. The project expects to generate key innovations such as developing a new, high performance, bio-based and biodegradable WPC by incorporating native spinifex-derived nano-cellulose fibres, ensuring excellent, molecular-level dispersion with a novel low-cost and energy-efficient wet-mix technology. This will provide significant benefits as it will lead to new products and markets for the Australian forestry industry and for rural and indigenous Australia, maximising Australia’s competitive advantage in biomass-derived products.Read moreRead less
Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle ....Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle and adipose tissue by stimulating the movement of a glucose transport protein from inside the cell to the cell surface (see http:--www.imb.uq.edu.au-groups-james-glut4 for an animated description of this process). The purpose of this proposal is to dissect the molecular mechanisms by which this glucose transporter can be held inside the cell in the absence of insulin and then allowed to be released from this site moving to the surface in the presence of insulin. Our studies over the past 5 years have brought us much closer to understanding this process in detail. The identification of the molecules responsible for this regulatory step will not only aid our understanding of this process but it will also provide a valuable target for development of therapeutic agents that can be used to combat insulin resistance.Read moreRead less
Tolerising Antigen-specific Immunotherapy For Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$1,395,549.00
Summary
We have developed a new immunotherapy to treat the underlying causes of type 1 diabetes (T1D) while leaving the rest of the immune system intact. To use this in patients, we need better tests to know when immune therapy is working. We will develop new methods to design the therapy and tools to track the relevant immune cells in T1D that work in variable patient groups. The knowledge gained will speed the pace of development and increase the chance of success of immunotherapy in T1D.
SYNTHESIS OF A NANO-STRUCTURED TITANIA SURFACE AND ITS APPLICATION IN PHOTOCATALYTIC OXIDATION FOR WATER TREATMENT. Australia is facing severe freshwater crisis. Although there is an increasing public awareness of saving and using water efficiently, re-using water/wastewater has been neglected. In Australia, 97% of city runoff and 86% of effluent water is unproductive. How to recycle and re-use them becomes an urgent issue. This project attempts to develop novel titania based photocatalysts to c ....SYNTHESIS OF A NANO-STRUCTURED TITANIA SURFACE AND ITS APPLICATION IN PHOTOCATALYTIC OXIDATION FOR WATER TREATMENT. Australia is facing severe freshwater crisis. Although there is an increasing public awareness of saving and using water efficiently, re-using water/wastewater has been neglected. In Australia, 97% of city runoff and 86% of effluent water is unproductive. How to recycle and re-use them becomes an urgent issue. This project attempts to develop novel titania based photocatalysts to convert organic contaminated water into reusable/potable freshwater. The project's innovation lies in the synthesis of highly reactive nano-structured titania surfaces in fixed form to solve downstream separation problem. Successful development of such photocatalysts will show significant environmental and socio-economic benefits to Australia.Read moreRead less