Voices of Regional Australia: The linguistic patterning of local attachment. This project aims to investigate language and social dynamics among regional Australians, who, despite representing one third of the population, have been often neglected in the research to date. The project expects to generate new knowledge around regional attachment and the impact that has on speech patterns, adapting for the first time recently developed international metrics to the Australian context. Expected outco ....Voices of Regional Australia: The linguistic patterning of local attachment. This project aims to investigate language and social dynamics among regional Australians, who, despite representing one third of the population, have been often neglected in the research to date. The project expects to generate new knowledge around regional attachment and the impact that has on speech patterns, adapting for the first time recently developed international metrics to the Australian context. Expected outcomes include a better understanding of models of language change across urban and rural areas, and a novel dataset recording the stories of regional Australians, and in particular, their experiences facing bushfire. This should provide significant benefits as a record of life, language and community in regional Australia.Read moreRead less
Languages of Barrier Islands, Sumatra: Description, History and Typology. This project aims to investigate endangered languages of the Asia-Pacific via four undocumented languages in the Barrier Islands, Indonesia. New knowledge will be generated into the languages, cultures and societies of the region on an unprecedented scale, and be made freely available to the public. New data will uncover past migration patterns in Southeast Asia, advance language theory (such as linguistic typology and lan ....Languages of Barrier Islands, Sumatra: Description, History and Typology. This project aims to investigate endangered languages of the Asia-Pacific via four undocumented languages in the Barrier Islands, Indonesia. New knowledge will be generated into the languages, cultures and societies of the region on an unprecedented scale, and be made freely available to the public. New data will uncover past migration patterns in Southeast Asia, advance language theory (such as linguistic typology and language change), and support the computational modelling of Austronesian for future language technologies. Connections with Indonesian institutions will strengthen Australia’s regional engagement, and support language revitalisation and maintenance among minority communities for the preservation of their culture and history.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Novel Insights Into The Mechanisms Of How Viruses Cause Arthritis-arthralgia
Funder
National Health and Medical Research Council
Funding Amount
$626,459.00
Summary
Many viruses are known to cause arthritis (e.g. HIV, hepatitis viruses, mosquito borne viruses). Symptoms of viral arthritis include joint pain, stiffness, and swelling. The mechanism of disease is poorly understood. We have developed a novel animal model of disease by which to study arthritic disease caused by viral infections. This model provides an excellent opportunity to explore the mechanisms of rheumatic disease in a complete functioning animal and to explore new treatment regimes.