The rapid interactions of circulating human blood platelets is critical to prevent bleeding, but can cause thrombotic diseases (heart attack, stroke). These highly regulated interactions involve specific adhesive proteins. Our studies will define factors regulating platelet interactions. Imaging the thrombotic process will quantify platelet function at an unprecedented resolution and we have a panel of new candidate reagents that will be assessed for antithrombotic potential.
Unraveling the variability in the protein expression in tissues or cell populations is critical to understand how cells respond to their environment. For example, this can provide details about the cellular response to an infection or to a chemoterapic. As of today, single cell protein analyses has become at reach, but its application is still cumbersome and its throughput is low. This proposal aims to develop and deploy a simple and robust method to analyse the protein content in single cells.
Leaving No-one Behind: Informing Indigenous Aged Care Policy With Big Data.
Funder
National Health and Medical Research Council
Funding Amount
$1,668,851.00
Summary
Very little is known about older Indigenous people in aged care. Led by Indigenous people, this project will use a unique national dataset to answer questions on the experiences of Indigenous people in aged care, focusing on access and barriers to services and care, quality and safety of care and whether the care they receive meets their health needs. This research will inform service improvements and ensure older Indigenous people are not forgotten in much-needed aged care reforms.