Gene Discovery And Characterisation In The Familial Focal Epilepsies
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Around 2% of people have epilepsy at some time in their lives. A large proportion of cases are thought to have a genetic cause, but genes have not yet been identified for most patients. The aim of this project is to use state-of-the-art genetic methods to identify genetic mutations causing epilepsy and to then study the effects of these mutations to better understand the biological causes of epilepsy. This in turn will lead to better diagnosis of epilepsy and improved treatment for patients.
LINEs Of Mutagenesis, Selection And Evolution In Ovarian Cancer And Chemoresistance
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
L1 elements are powerful mutagens encoded within the human genome that becomes active in epithelial tumours. I will define the broad effects of L1 elements on the evolution of chemoresistance, focusing on ovarian cancer as a model system. Ovarian cancer is characterised by a poor 5 year survival rate of ~40% with most tumours developing resistance. Understanding the impacts of L1 on this evolution will inform the development and selection of more effective treatments for ovarian cancer.
Practice- And Policy-relevant Research In Skin Cancer Epidemiology, Prevention And Screening
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
This Fellowship will enable me to lead an internationally-competitive program of research in skin cancer epidemiology, prevention & screening that will lead to improved patient and population health through impacts on clinical practice and health policy. My aim is to lead paradigm-shifting contributions in: ? Genetic epidemiology of melanoma, ? Precision skin cancer prevention & screening, and ? Public health genomics for cancer prevention.
Preventing Suicide In Young People: A Public Health Approach
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Suicide is the leading cause of death in young Australians. This fellowship aims to lower risk for suicide by testing: a) whether improving the connectedness of adolescents in schools can improve help-seeking, b) whether parents can learn to recognise risk in their children, and c) whether school screening is an appropriate and effective strategy to reduce risk. Practical outcomes will be new programs for youth, new strategies for parents and a better integrated approach for Australian schools.
Massive Parallel Sequencing In The Genetics Of Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
Epilepsy is a serious disorder which affects approximately 2% of the population at some stage in their life and around 30% of patients do not gain adequate control of their seizures with medications presently available. Approximately 70% of epilepsy in inherited and so far the majority of the genetic causes are yet to be discovered. My group aims to identify new epilepsy genes. This leads to improved diagnosis, treatment and counseling for patients and increased understanding of the biological m ....Epilepsy is a serious disorder which affects approximately 2% of the population at some stage in their life and around 30% of patients do not gain adequate control of their seizures with medications presently available. Approximately 70% of epilepsy in inherited and so far the majority of the genetic causes are yet to be discovered. My group aims to identify new epilepsy genes. This leads to improved diagnosis, treatment and counseling for patients and increased understanding of the biological mechanisms underlying seizures.Read moreRead less
Evaluation Of New Screening Strategies For Prevention Of Cancer
Funder
National Health and Medical Research Council
Funding Amount
$251,144.00
Summary
Governments, clinicians and consumers have a need for accurate and up-to-date information about the cost-effectiveness, benefits and harms of cancer screening. This project will evaluate whether further changes to cervical screening will be needed after the release of next generation HPV vaccines, whether new screening programs should be implemented for lung cancer and Lynch syndrome, the potential role of new technologies for bowel screening, and whether prostate testing can be improved.
Significance Of Low-level Mosaicism To Intellectual Disability In Paediatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$483,402.00
Summary
My vision for the next 4 years is to improve outcomes for children and their families with inherited disorders associated with intellectual disability (ID) and autism through earlier diagnosis and intervention. This is of great importance with annual costs of ID close $14.72 billion to the Australian health system, and missed or delayed diagnoses being a significant problem, as ID is found in 1.7% of births, where a specific cause is currently identified in less than half.
Evaluation Of Future Cervical Cancer Prevention Strategies In Australia
Funder
National Health and Medical Research Council
Funding Amount
$401,361.00
Summary
The overall aim of the project is to use simulation modelling to perform a detailed epidemiologic and economic evaluation of the role of primary HPV DNA testing in Australia in the context of HPV vaccination. The project involves a collaboration with investigators at the National Cancer Institute USA, to analyse data from large studies conducted around the world and to build an accurate simulation of HPV infection and the development of cervical cancer.