Switching the light on cartilage repair. Osteoarthritis is a leading cause of pain and disability in adults and affects 15 per cent of the Australian population. This project will develop a revolutionary new approach to treat joint disorders using smart materials and stem cells. The novel materials and techniques developed will help Australia maintain its leading edge in biotechnology.
Development of new systems for the commercial collection, processing and storage of adipose stem cells. This project is aimed at developing a standardised method to commercially extract and expand stem cells from adipose tissue. This product will then be available commercially as a therapeutic treatment.
The development of new scaffolds for bone repair comprising polycaprolactone and strontium-substituted bioactive glasses. The drive to develop bone grafts to fill major gaps in the skeleton, whilst circumventing the need to use permanent implants has led to a major research thrust towards developing biomaterials for bone-tissue engineering. The project will develop scaffolds with highly osteoconductive bioactive glasses in a polymer matrix for bone regeneration applications.
Smart Matrix™ approaches towards neo vascularisation in bone repair. Bone injuries cost Australia more than $1 billion annually. The development of a medical device combining novel pro-angiogenic technology, Smart Matrix™, with polymer scaffolds for treatment of bone defects by this project, will facilitate rapid development of a blood supply within the defect, aiding bone growth and reducing overall costs compared to current treatments.
Dissecting the physiology of multipotent mesenchymal stromal cells to develop vaccine candidates for respiratory disease. The project aims to gain an understanding of how a type of adult stem cell inhibits immune responses that cause asthma. The project will produce new stem cell products and facilitate the design of a vaccine for asthma and other respiratory diseases, which would greatly reduce the burden of such conditions.
Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tib ....Bone tissue engineering using innovative tubular dual-layered nanofiber meshes. Lifetime risks for long-bone fractures in Caucasians over the age of 50 are 17 per cent for women and 6 per cent for men. A clear therapeutic need exists to address the ever-increasing problems of diminished productivity and reduced quality of life associated with bone disorders as the population ages. To address this challenge, the project’s multidisciplinary, international team will develop technologies to heal tibial defects. Furthermore, it will establish Australia's prominence in the tissue engineering field, training the next generation of young scientists and engineers. This technology will be of interest to numerous research groups and companies worldwide and will foster international collaboration, placing Australia at the forefront of this emerging field.Read moreRead less
An automated system for the analysis of road safety and conditions. This project aims to develop an automated system for the analysis of road safety and conditions. Digital video road data is collected over every state road in Queensland annually, and has the potential to provide a range of value-added products for safer roads. This project will develop deep learning based neural network techniques which can learn and classify roadside objects so that video data can be automatically analysed all ....An automated system for the analysis of road safety and conditions. This project aims to develop an automated system for the analysis of road safety and conditions. Digital video road data is collected over every state road in Queensland annually, and has the potential to provide a range of value-added products for safer roads. This project will develop deep learning based neural network techniques which can learn and classify roadside objects so that video data can be automatically analysed allowing the estimation of the proximity of objects for road safety and rating. The expected outcome will be new identification techniques and software which can be incorporated with road data collection systems.Read moreRead less
Application of artificial neural network in flood emergency decision support system. This project will develop a method for rapid estimation of flood water levels. This will increase the warning time for flood evacuation in small coastal catchments where traditional estimating techniques are too time-consuming.
Improving the modelling of insolvency risk and financial health assessment of global companies using hybrid intelligent techniques. The social and economic impacts of corporate collapses are severe, and much research has modelled financial health and insolvency risk of companies. Most research, however, uses simple and out-dated financial ratios used by Altman (1968), and attempts to develop a universal model valid for specific (non-global) markets. Our approach is to improve the relevance of th ....Improving the modelling of insolvency risk and financial health assessment of global companies using hybrid intelligent techniques. The social and economic impacts of corporate collapses are severe, and much research has modelled financial health and insolvency risk of companies. Most research, however, uses simple and out-dated financial ratios used by Altman (1968), and attempts to develop a universal model valid for specific (non-global) markets. Our approach is to improve the relevance of the information provided to the models (including measures of strategy, recent accounting metrics, global context). We also challenge the merits of a universal model by developing and testing a novel hybrid intelligent approach combining neural networks, genetic algorithms and self-organising maps, applicable to global markets.Read moreRead less
Vision Model Based Perceptual Digital Video Coding. Digital video coding and compression is an enabling technology and has diversified applications in audiovisual communications, multimedia computing, digital television broadcast and electronic entertainment industries. The project aims at spearheading research in theory, techniques and implementation of perceptual video coding in order to achieve constant and guaranteed quality in visual communications and services. It will explore a new appr ....Vision Model Based Perceptual Digital Video Coding. Digital video coding and compression is an enabling technology and has diversified applications in audiovisual communications, multimedia computing, digital television broadcast and electronic entertainment industries. The project aims at spearheading research in theory, techniques and implementation of perceptual video coding in order to achieve constant and guaranteed quality in visual communications and services. It will explore a new approach to digital video coding other than the constant bit rate coding techniques which have dominated digital video research for the past four decades. It will form a part of the theoretical foundation and principles for the next generation video coding and compression techniques, and may lead to new standards and practice.Read moreRead less