STABILISING G PROTEIN-COUPLED RECEPTORS FOR DRUG DISCOVERY
Funder
National Health and Medical Research Council
Funding Amount
$628,140.00
Summary
Prescription drugs targeting human proteins called GPCRs are sold as effective treatments for many diseases. However, there are over 800 different types of GPCRs in the human body and only a small fraction is targeted by drugs, mainly because GPCRs are unstable and thus difficult to work with in the laboratory. We are applying newly developed technologies to engineer stabilised ?1-adrenoceptors, a class of GPCRs, for drug discovery against cardiovascular diseases, epilepsy and neurodegeneration
Novel Approaches To Understanding Peptide G-protein-coupled Receptor Activation
Funder
National Health and Medical Research Council
Funding Amount
$665,043.00
Summary
G protein-coupled receptors (GPCRs) are proteins that exist on every human cell, where they sense, and respond to environmental stimuli. Because of their importance they are targeted by drugs to treat many diseases. However little is known about the molecular steps that underlie cellular responses upon drug binding and this has hindered new drug development. This project uses new technology to determine the complex pathway of GPCR activation upon drug binding which will aid new drug development.
Novel approaches to studies of violations of fundamental symmetries of nature. This project will contribute to research at the leading edge of fundamental physics. This is an international project that incorporates intensive collaboration with US experimental groups which will base their work on our calculations. Ultimately these studies will shed light on the origin of matter-antimatter asymmetry in the Universe.
Unravelling The Binding And Activation Mechanism Of A Complex G Protein-coupled Receptor
Funder
National Health and Medical Research Council
Funding Amount
$1,041,638.00
Summary
The peptide hormone relaxin is currently in a Phase III trial for the treatment of heart failure. However the peptide is not a good drug as it can't be taken orally and is very expensive to produce. We will study the interaction of relaxin with its cell surface receptor and the mechanisms by which the receptor functions. The knowledge gained will aid in the design of smaller, more potent and orally active forms of relaxin for the treatment of heart failure
Magnetic moments of radioactive beams - an incisive probe of novel structures in neutron-rich nuclei. This project gives Australian scientists, whose expertise underpins recent ground-breaking success, the opportunity for continued leadership in research with international large-scale radioactive beam facilities - a scientific frontier of high technical and intellectual standing. In the process of studying the fundamental goal of nuclear physics, to reach a unified understanding of all nuclei, i ....Magnetic moments of radioactive beams - an incisive probe of novel structures in neutron-rich nuclei. This project gives Australian scientists, whose expertise underpins recent ground-breaking success, the opportunity for continued leadership in research with international large-scale radioactive beam facilities - a scientific frontier of high technical and intellectual standing. In the process of studying the fundamental goal of nuclear physics, to reach a unified understanding of all nuclei, it will develop the basic science needed for future applications of exotic isotopes, e.g. in materials science and medicine. Including experiments in Australia and abroad, it offers an exceptional breadth of training to address the shortage of nuclear expertise needed by the health sector, industry, government, and for national security.Read moreRead less
Resolving And Targeting The Complex Molecular Mechanisms Underlying GPCR Signalling
Funder
National Health and Medical Research Council
Funding Amount
$1,071,370.00
Summary
Receptors are located on the surface of all human cells to allow our cells to respond to their environment. Over 30% of prescription drugs act through particular receptors called GPCRs, however effective drugs without side effects are difficult to develop because we do not have a deep understanding of how GPCRs transmit complex signals. In this proposal we seek to resolve the atomic-level details of GPCR signalling to assist in the development of better drugs for a diverse range of diseases.
Nanostructure engineered low activation superconductors for fusion energy. This project aims to develop a novel, low activation and liquid helium-free superconducting solution with superior electromagnetic, mechanical and thermal properties for use in fusion reactors. Superconducting magnets and their associated cryogenic cooling systems represent a key determinant of thermal efficiency and the construction/operating costs of fusion reactors. The project expects to overcome these barriers so tha ....Nanostructure engineered low activation superconductors for fusion energy. This project aims to develop a novel, low activation and liquid helium-free superconducting solution with superior electromagnetic, mechanical and thermal properties for use in fusion reactors. Superconducting magnets and their associated cryogenic cooling systems represent a key determinant of thermal efficiency and the construction/operating costs of fusion reactors. The project expects to overcome these barriers so that widespread uptake of these reactors becomes viable. Outcomes from the project will include a fundamental understanding of pure and doping-induced isotopic magnesium diboride superconductors and their behaviour under high neutron flux and harsh plasma atmosphere, which are specifically designed for application in next-generation, low-cost fusion reactors.Read moreRead less
Superfluidity in strongly correlated ultra-cold atomic Fermi gases. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics were awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with new ultra-cold fermion experiments now underwa ....Superfluidity in strongly correlated ultra-cold atomic Fermi gases. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics were awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with new ultra-cold fermion experiments now underway in Melbourne. This project will build national and international cooperation in this field, provide world-class research training opportunities and advance Australia's leadership position. As well as improving scientific understanding, it has the potential to lead to new energy-saving technologies in the future.Read moreRead less
Ultracold atomic Fermi gases in the strongly interacting regime: A new frontier of quantum many-body physics. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics have been awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with ....Ultracold atomic Fermi gases in the strongly interacting regime: A new frontier of quantum many-body physics. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics have been awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with new cold-fermion experiments now underway in Melbourne. This project will build national and international cooperation in this field, provide world-class research training opportunities and advance Australia's leadership position. As well as improving scientific understanding, it has the potential to lead to new energy-saving technologies in future.Read moreRead less
Imbalanced superfluidity: The quantum mystery that defies solution. The project focuses on ground-breaking research in ultra-cold atomic Fermi gases, the fastest developing area in twenty-first century physics. Australia has already invested heavily in ultra-cold atomic Bose gases including atom lasers. An experimental program on atomic Fermi gases has also been initiated in the ARC Centre of Excellence for Quantum-Atom Optics (ACQAO). Our project, if successful, will help elevate Australia to a ....Imbalanced superfluidity: The quantum mystery that defies solution. The project focuses on ground-breaking research in ultra-cold atomic Fermi gases, the fastest developing area in twenty-first century physics. Australia has already invested heavily in ultra-cold atomic Bose gases including atom lasers. An experimental program on atomic Fermi gases has also been initiated in the ARC Centre of Excellence for Quantum-Atom Optics (ACQAO). Our project, if successful, will help elevate Australia to a major international research centre in cold Fermi gases, complementing its ongoing strength developed through the ACQAO experiments, and will bring fundamental knowledge that could have a significant and profound influence upon future technologies: for example, novel electronics, lossless power transmission and magnetic levitation.Read moreRead less