Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Molecular Regulation Of Metabolism And Body Composition By Ski Via Crosstalk With Nuclear Hormone Receptor Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$558,441.00
Summary
Obesity is a common and burdensome health problem in the community which leads to diabetes and heart disease. A number of factors, including hormones play important roles in determing risk of obesity. This study proposes to investigate whether the Ski gene which is a regulatory factor for many hormones affects metabolism in transgenic mouse models of altered Ski function. The proposed studies may identify Ski as a target for therapy for obesity and improvement in sketal muscle metabolism.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882224
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Vector Magnetic Field Facility for Nanoscale Spintronic Materials and Device Research. Electronic devices underpin a trillion dollar industry worldwide and are an essential part of modern life. Spintronics (spin-electronics) is an emergent technology that combines the electrical and magnetic properties of electrons to represent and process information. Spintronic chips are expected to be fast, versatile, capable of simultaneous data storage and processing, while at the same time consuming less ....Vector Magnetic Field Facility for Nanoscale Spintronic Materials and Device Research. Electronic devices underpin a trillion dollar industry worldwide and are an essential part of modern life. Spintronics (spin-electronics) is an emergent technology that combines the electrical and magnetic properties of electrons to represent and process information. Spintronic chips are expected to be fast, versatile, capable of simultaneous data storage and processing, while at the same time consuming less energy. Industry analysts suggest the spintronic market will exceed $10 billion. This facility will provide the critical infrastructure needed to study the electronic and magnetic properties of nanostructured materials, providing the underpinning knowledge to develop the next generation of spintronic devices.Read moreRead less
Nonlinear quantum science with superconducting circuit quantum-electrodynamics. Circuit quantum electrodynamics has rapidly emerged in recent years as a new field of experimental quantum science, with applications to precision measurement, nanomechanical transducers and quantum information processing. We will design and demonstrate new experimental devices, grounded in a long-standing expertise in quantum optics, and enabled by a new low temperature laboratory under development at The Universit ....Nonlinear quantum science with superconducting circuit quantum-electrodynamics. Circuit quantum electrodynamics has rapidly emerged in recent years as a new field of experimental quantum science, with applications to precision measurement, nanomechanical transducers and quantum information processing. We will design and demonstrate new experimental devices, grounded in a long-standing expertise in quantum optics, and enabled by a new low temperature laboratory under development at The University of Queensland. This project will deliver a new technological capability for Australia.Read moreRead less
Modelling quantum dynamics of electronic excited states in complex molecular materials. Understanding new materials that are the basis of new sources of renewable energy sources represents a major scientific challenge. Many of these materials are composed of large organic molecules containing hundreds of atoms. Their properties and the concepts needed to understand these materials are distinctly different from semiconductors such as silicon. This research will enhance our ability to design bett ....Modelling quantum dynamics of electronic excited states in complex molecular materials. Understanding new materials that are the basis of new sources of renewable energy sources represents a major scientific challenge. Many of these materials are composed of large organic molecules containing hundreds of atoms. Their properties and the concepts needed to understand these materials are distinctly different from semiconductors such as silicon. This research will enhance our ability to design better materials and optimize the performance of organic solar cells and LEDs. Australia's capacity for research and development in this scientifically challenging and technologically important field will be enhanced by this project. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100060
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
High pressure facility for optical spectroscopy: investigation of novel superconductors and strongly correlated electron systems. Superconductivity is an effect where the electrical resistance disappears completely at low temperatures. This facility will permit optical spectroscopy under high hydrostatic pressure to reveal important new information leading to a deeper understanding of this effect.
ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies ....ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies (CAMS) will bring together key Australian and international scientists to work in this emerging scientific field of antimatter-matter interactions. It will forge a unique and effective scientific team for state-of-the-art studies of the nano-world that underlies many everyday processes and new technologies.Read moreRead less
Centre for Quantum Computer Technology. Development of a quantum computer (QC) for massively parallel computing is one of the major challenges in science and engineering this century. Since 2000 the Centre has achieved two major breakthroughs in this field: constructing the key functional element of a silicon solid-state QC; and co-inventing a scheme for efficient linear optics QC. The proposed CoE aims to align these two nationally co-ordinated research programs with the world's existing comput ....Centre for Quantum Computer Technology. Development of a quantum computer (QC) for massively parallel computing is one of the major challenges in science and engineering this century. Since 2000 the Centre has achieved two major breakthroughs in this field: constructing the key functional element of a silicon solid-state QC; and co-inventing a scheme for efficient linear optics QC. The proposed CoE aims to align these two nationally co-ordinated research programs with the world's existing computer and IT industries to realise a fault-tolerant multiple qubit quantum processor with integrated control and qubit chips, and develop a scaleable optical quantum processor providing significant economic benefit to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668510
Funder
Australian Research Council
Funding Amount
$180,240.00
Summary
Nanostructure Deposition Facility. New electronic devices and materials that exploit the properties of nanostructured surfaces are predicted to have a major impact on everyday life in areas such as information technology, biotechnology and healthcare. The Nanostructure Deposition Facility (NDF) is a unique facility, providing access to the highly specialised deposition equipment required to fabricate these important nanostructured surfaces from a variety of materials. The NFDL represents a major ....Nanostructure Deposition Facility. New electronic devices and materials that exploit the properties of nanostructured surfaces are predicted to have a major impact on everyday life in areas such as information technology, biotechnology and healthcare. The Nanostructure Deposition Facility (NDF) is a unique facility, providing access to the highly specialised deposition equipment required to fabricate these important nanostructured surfaces from a variety of materials. The NFDL represents a major new joint venture between seven Australian institutions and will provide these researchers with the essential tools for developing new electronic devices, biosensors, detectors and solar cells based on nanotechnology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0239044
Funder
Australian Research Council
Funding Amount
$195,000.00
Summary
Next generation organic electronic and optoelectronic device fabrication facility. This application will establish a unique facility to fabricate a new generation of plastic electronic devices. Whilst organic devices have been proposed for several years, a series of breakthroughs in the development of fabrication technologies in the last year have produced novel inexpensive solar cells, lasers, transistors and superconducting electronic devices made from organic materials. At present there is no ....Next generation organic electronic and optoelectronic device fabrication facility. This application will establish a unique facility to fabricate a new generation of plastic electronic devices. Whilst organic devices have been proposed for several years, a series of breakthroughs in the development of fabrication technologies in the last year have produced novel inexpensive solar cells, lasers, transistors and superconducting electronic devices made from organic materials. At present there is no facility to fabricate these devices in Australia, although the potential market for optoelectronic applications exceeds US$12 billion. The proposed facility will enable Australia to actively partake in the development of this new technology at its early stages.Read moreRead less