Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100036
Funder
Australian Research Council
Funding Amount
$4,999,600.00
Summary
ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical ....ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical production, more resilient spacecraft and robust regulatory frameworks. Industries and communities will benefit from a future workforce prepared for safe adoption, development and delivery of emerging techniques and advanced radiation technologies, enhancing Australia’s prosperity and security.Read moreRead less
Centre for Quantum Computer Technology. Development of a quantum computer (QC) for massively parallel computing is one of the major challenges in science and engineering this century. Since 2000 the Centre has achieved two major breakthroughs in this field: constructing the key functional element of a silicon solid-state QC; and co-inventing a scheme for efficient linear optics QC. The proposed CoE aims to align these two nationally co-ordinated research programs with the world's existing comput ....Centre for Quantum Computer Technology. Development of a quantum computer (QC) for massively parallel computing is one of the major challenges in science and engineering this century. Since 2000 the Centre has achieved two major breakthroughs in this field: constructing the key functional element of a silicon solid-state QC; and co-inventing a scheme for efficient linear optics QC. The proposed CoE aims to align these two nationally co-ordinated research programs with the world's existing computer and IT industries to realise a fault-tolerant multiple qubit quantum processor with integrated control and qubit chips, and develop a scaleable optical quantum processor providing significant economic benefit to Australia.Read moreRead less
ARC Centre of Excellence for Quantum Computation and Communication Technology. This Centre aims to implement quantum processors able to run error corrected algorithms and transfer information across networks with absolute security. Australian researchers have established global leadership in quantum information, an innovative technology which could transform all industries dependent on computational power. This Centre has developed technologies for manipulating matter and light at the level of i ....ARC Centre of Excellence for Quantum Computation and Communication Technology. This Centre aims to implement quantum processors able to run error corrected algorithms and transfer information across networks with absolute security. Australian researchers have established global leadership in quantum information, an innovative technology which could transform all industries dependent on computational power. This Centre has developed technologies for manipulating matter and light at the level of individual atoms and photons, with the highest fidelity, longest coherence time qubits in the solid state, the world’s longest-lived quantum memory, and the ability to run small-scale algorithms on photonic qubits. The new technology is expected to provide a strategic advantage in a world where information and information security are of paramount importance.Read moreRead less
ARC Centre of Excellence for Quantum Computation and Communication Technology. The Centre for Quantum Computation and Communication Technology will coordinate a large team of Australian researchers in an intensive mission. Our aim is to integrate a radical and uniquely powerful Australian computing technology with an ultra-secure Australian communications technology. Our success will drive global productivity gains in information processing and ensure that Australians own the pivotal underpinnin ....ARC Centre of Excellence for Quantum Computation and Communication Technology. The Centre for Quantum Computation and Communication Technology will coordinate a large team of Australian researchers in an intensive mission. Our aim is to integrate a radical and uniquely powerful Australian computing technology with an ultra-secure Australian communications technology. Our success will drive global productivity gains in information processing and ensure that Australians own the pivotal underpinning intellectual property. Our technologies will provide Australia and its allies with the world's most secure information networks. Our discoveries will place Australia unequivocally at the very forefront of global research in quantum physicsRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100081
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The pr ....Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The proposed facility will provide significant benefits to Australian researchers in drug design and delivery, nano-material design and characterisation at nano scale for advanced materials, and promotion of renewable energy. This represents a great opportunity to make discoveries and breakthroughs in frontier science and technology in Australia.Read moreRead less
ARC Centre of Excellence in Future Low Energy Electronics Technologies. This Centre aims to develop the scientific foundation and intellectual property for new electronics technologies. Decreasing energy use is a major societal challenge, and this Centre aims to meet that challenge by realising fundamentally new types of electronic conduction without resistance in solid-state systems at room temperature. Novel resistance-free electronic phenomena at room temperature are expected to form the basi ....ARC Centre of Excellence in Future Low Energy Electronics Technologies. This Centre aims to develop the scientific foundation and intellectual property for new electronics technologies. Decreasing energy use is a major societal challenge, and this Centre aims to meet that challenge by realising fundamentally new types of electronic conduction without resistance in solid-state systems at room temperature. Novel resistance-free electronic phenomena at room temperature are expected to form the basis of integrated electronics technology with ultra-low energy consumption. This Centre’s development of innovative electronics could put Australia at the forefront of the international electronics industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100223
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Advanced X-ray diffraction facility for high energy and extreme conditions. X-ray powder diffraction is a powerful technique for determining the structure of matter at the atomic scale. This project will establish a new Australian capability for X-ray powder diffraction under extreme conditions that emulate real harsh service environments for advanced functional materials.