Creation of a super-resolution map of the bacterial cytokinesis machinery . Cell division is a fundamental process essential for life. Yet our understanding of this process on a molecular level is limited, mostly hampered by the inability to visualize the different components of the division machinery inside these tiny cells with adequate resolution. To overcome this barrier, capitalizing on recent advancements in imaging and molecular technologies combined with innovative engineering, this proj ....Creation of a super-resolution map of the bacterial cytokinesis machinery . Cell division is a fundamental process essential for life. Yet our understanding of this process on a molecular level is limited, mostly hampered by the inability to visualize the different components of the division machinery inside these tiny cells with adequate resolution. To overcome this barrier, capitalizing on recent advancements in imaging and molecular technologies combined with innovative engineering, this project aims to create a spatial and temporal map of the division machinery inside bacterial cells at unprecedented resolution. The expected outcomes are new knowledge on the mechanism of bacterial division and technological advances in biological imaging, informing applications in a wide variety of sectors.Read moreRead less
Background-free imaging of single membrane-receptors with nanophosphors. This project aims to develop nanophosphor beacons and real-time, ultrahigh-sensitivity functional imaging to provide a picture of the brain. Time-gated detection microscopy will give these nanophosphors a superior optical contrast. The nanophosphors’ antibody-targeting will image single AMPA membrane receptors in their full biological context, crucial to understanding neuronal signalling. Simultaneous imaging of receptor tr ....Background-free imaging of single membrane-receptors with nanophosphors. This project aims to develop nanophosphor beacons and real-time, ultrahigh-sensitivity functional imaging to provide a picture of the brain. Time-gated detection microscopy will give these nanophosphors a superior optical contrast. The nanophosphors’ antibody-targeting will image single AMPA membrane receptors in their full biological context, crucial to understanding neuronal signalling. Simultaneous imaging of receptor trafficking and activity in neurons will help to uncover details of the dynamic activity in the brain. This technology is expected to help understand the inner workings of the brain and provide insights into its functioning.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100001
Funder
Australian Research Council
Funding Amount
$410,000.00
Summary
Collaborative advanced spectroscopy facility for materials and devices. Collaborative advanced spectroscopy facility for materials and devices: This project aims to enable advancements in electronics, photonics, biomedicine, and sensing through a collaborative, open access facility for advanced optical and chemical spectroscopy of thin films, materials, and devices. The intended capabilities include high-speed, precise and state-of-the-art spectroscopy tools which enable in situ characterisation ....Collaborative advanced spectroscopy facility for materials and devices. Collaborative advanced spectroscopy facility for materials and devices: This project aims to enable advancements in electronics, photonics, biomedicine, and sensing through a collaborative, open access facility for advanced optical and chemical spectroscopy of thin films, materials, and devices. The intended capabilities include high-speed, precise and state-of-the-art spectroscopy tools which enable in situ characterisation at sub-micron scales and cryogenic temperatures, under bio-simulated environments, down to single pixel resolution, with parallel imaging and spectroscopy, and of fluids and biomaterials. The instrumentation will include cryogenic sub-micron photoluminescence and micro-Raman spectroscopy, single pixel optical and dark field spectroscopy, continuous wave terahertz time-domain spectroscopy, wide wavelength microscopic spectroscopy, and temperature-jump kinetics spectroscopy. It is expected that these complementary instruments will accelerate research in materials and devices for plasmonics, nanoelectronics, biomedicine, biochemistry, security, and forensic science.Read moreRead less