Utilisation of dense gas technology for the development of controlled release active pharmaceutical ingredients (API) delivery systems. The aim of this project is to develop an orally administered drug formulation for the treatment of irritable bowel syndrome and other diseases of the colon. Irritable bowel syndrome is a debilitating condition and the cost to society is similar to that of asthma. As such, the project has the potential to have a major impact on society.
A multimodal approach to unravel the role of surface properties in nanoparticle-cell interactions using models of medical emergencies. The design and development of multimodal nanoparticles seek to expand upon the benefits of nanoparticles by delivering imaging and therapeutic agents to specific organs, enabling detection and treatment of disease in a single procedure. The successful implementation of this technology is dependent on our detailed understanding of the nanoparticle-cell interaction ....A multimodal approach to unravel the role of surface properties in nanoparticle-cell interactions using models of medical emergencies. The design and development of multimodal nanoparticles seek to expand upon the benefits of nanoparticles by delivering imaging and therapeutic agents to specific organs, enabling detection and treatment of disease in a single procedure. The successful implementation of this technology is dependent on our detailed understanding of the nanoparticle-cell interactions. This project will address this very important issue by evaluating a range of surface functionalised nanoparticles in highly significant models of medical emergencies. This project will enable development of advanced therapeutic interventions for cancer, central nervous system injuries, cardiovascular diseases and pregnancy related disorders.Read moreRead less
Nanoscale liquid interfaces: properties and molecular sensitivity. Challenges facing society in health and environment need new molecular measurements that are accurate, sensitive and fast. By use of nanoscale oil-water junctions, the project will develop new chemical and biological sensors that hold great promise for solving molecular measurement problems, including the ability to detect single molecules.
Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The l ....Establishing Design Principles Of Polymers For Intracellular Delivery . Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100100
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges ....Cytometer by Time of Flight (CyTOF): A New Paradigm in Cytometry. Cytometer by Time of Flight (CyTOF) - a new paradigm in cytometry: The acquisition of a Cytometer by Time of Flight will allow multiparametric characterisation of biological systems and quantitative analysis of nano-bio interactions at the single cell level. The convergence of nanotechnology with biomedicine offers unprecedented opportunities for biological applications, including targeted therapeutics. One of the major challenges lies in understanding the complex interactions between nanoengineered materials and biological systems.Read moreRead less
Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineerin ....Establishing nanoscale design principles for non-viral genome engineering. This project aims to develop a bio-nanotechnology platform for non-viral genome engineering using dendronised polymers. The project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community. Outcomes from the project will also provide significant benefits, such as positioning Australia at the forefront of genome engineering.Read moreRead less
Processing Pearl Nacre for Bio-Nanotechnology. Nanotechnology has exciting potential to solve major health challenges of the 21st century. The proposed research focuses on developing health care products, derived from a renewable waste stream resource from the pearling industry, en route to establishing products to benefit the rural community, and beyond. The processed pearl nacre provides the possibility of alleviating problems associated with neurotrauma following injury, and for skin regenera ....Processing Pearl Nacre for Bio-Nanotechnology. Nanotechnology has exciting potential to solve major health challenges of the 21st century. The proposed research focuses on developing health care products, derived from a renewable waste stream resource from the pearling industry, en route to establishing products to benefit the rural community, and beyond. The processed pearl nacre provides the possibility of alleviating problems associated with neurotrauma following injury, and for skin regeneration following burns. The recently established powerful multidisciplinary research team in partnership with Pearl Technology combines expertise in chemical processing, nanotechnology, biochemistry, neuroscience and tissue engineering, also providing a basis for quality research training.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100042
Funder
Australian Research Council
Funding Amount
$462,846.00
Summary
Developing a multimodal imaging pipeline for antisense technology. Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules a ....Developing a multimodal imaging pipeline for antisense technology. Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules across cells and tissues and refined imaging methods. This project should provide more strategic delivery of antisense molecules to specific cells and tissue, which will have significant downstream economic and social benefits to the Australian community. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100056
Funder
Australian Research Council
Funding Amount
$621,198.00
Summary
High-frequency ultrasound and photoacoustic imaging for Western Australia. This project aims to obtain a small animal, high-frequency ultrasound and photoacoustic imaging instrument, to be placed in the University of Western Australia's Centre for Microscopy, Characterisation and Analysis. As a node of the National Imaging Facility, this infrastructure will result in enhanced capacity for fundamental, interdisciplinary, biological, and bionanotechnology research in Western Australia, and enable ....High-frequency ultrasound and photoacoustic imaging for Western Australia. This project aims to obtain a small animal, high-frequency ultrasound and photoacoustic imaging instrument, to be placed in the University of Western Australia's Centre for Microscopy, Characterisation and Analysis. As a node of the National Imaging Facility, this infrastructure will result in enhanced capacity for fundamental, interdisciplinary, biological, and bionanotechnology research in Western Australia, and enable pursuit of projects previously only possible either interstate or internationally. New capacity in small animal in-vivo imaging will generate knowledge in biology, feeding into such areas as species conservation and reproductive health, and intellectual property and commercial opportunity in areas such as medical imaging and theranostics.Read moreRead less