Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100088
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
nano infrared and sub micron Raman spectroscopy and imaging. Nano infrared and sub micron raman spectroscopy and imaging: Near-field Infrared (IR) spectroscopy and imaging systems will be coupled to near-field scanning optical microscopes to provide IR spectroscopy and molecular images at less than 20 nanometre lateral resolution. This is unprecedented resolution for infrared fingerprinting and molecular imaging. For two months a year the spectroscopy system will be coupled to the IR beamline at ....nano infrared and sub micron Raman spectroscopy and imaging. Nano infrared and sub micron raman spectroscopy and imaging: Near-field Infrared (IR) spectroscopy and imaging systems will be coupled to near-field scanning optical microscopes to provide IR spectroscopy and molecular images at less than 20 nanometre lateral resolution. This is unprecedented resolution for infrared fingerprinting and molecular imaging. For two months a year the spectroscopy system will be coupled to the IR beamline at the Australian synchrotron, to provide full IR spectral coverage available to all Australian and New Zealand scientists. A confocal raman spectrometer will be upgraded to the ultraviolet to provide spectra at less than 150 nanometre resolution. These systems will provide a unique Australian resource for nanoscientists, biomedical researchers and materials scientists requiring molecular information on the nanoscale.Read moreRead less
Advanced framework materials for hydrogen storage applications. This project aims to develop new molecular materials capable of the highly efficient storage of hydrogen gas. Through an innovative interdisciplinary approach that targets the synthesis and detailed characterisation of two classes of molecular material this project expects to generate step-change advances in the understanding of how hydrogen gas uptake relates to the chemical and physical attributes of porous molecular systems. Sign ....Advanced framework materials for hydrogen storage applications. This project aims to develop new molecular materials capable of the highly efficient storage of hydrogen gas. Through an innovative interdisciplinary approach that targets the synthesis and detailed characterisation of two classes of molecular material this project expects to generate step-change advances in the understanding of how hydrogen gas uptake relates to the chemical and physical attributes of porous molecular systems. Significant anticipated outcomes and benefits include the development of new material design approaches that optimise performance across a diverse parameter space, and the generation of advanced new materials worthy of commercial development, spanning small scale mobile to large scale stationary storage applications.Read moreRead less
Novel Synthetic Receptors for Recognition and Transport of Biologically Important Anions. Anion receptors are not currently tailored for the ‘real world’ biological environments (for example, physiological saline and membranes) in which anions perform their many critical roles. The project will design and synthesise a range of molecular receptors based on large, rigid, precisely functionalisable scaffolds, tailored specifically to complement both the shape, size and charge of target anions as we ....Novel Synthetic Receptors for Recognition and Transport of Biologically Important Anions. Anion receptors are not currently tailored for the ‘real world’ biological environments (for example, physiological saline and membranes) in which anions perform their many critical roles. The project will design and synthesise a range of molecular receptors based on large, rigid, precisely functionalisable scaffolds, tailored specifically to complement both the shape, size and charge of target anions as well as their native environment. The project will investigate the ability of these receptors to strongly bind their target anions with high selectivity in both aqueous systems and in membrane environments. This will lead to the development of innovative synthetic receptors that recognise and/or transport biological anions for use in biomedical applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101176
Funder
Australian Research Council
Funding Amount
$445,000.00
Summary
Fluorescent probes for super-resolution imaging of the amyloid architecture. The goal of this project is to develop chemical tools that enable molecular-level imaging of the amyloid structure. The Nobel Prize-winning super-resolution microscopy provides nanoscale imaging capabilities, but surprisingly there have been no substantive efforts to design fluorescent sensors that are compatible with this cutting-edge technology. In this project, new fluorescent super-resolution sensors will be develop ....Fluorescent probes for super-resolution imaging of the amyloid architecture. The goal of this project is to develop chemical tools that enable molecular-level imaging of the amyloid structure. The Nobel Prize-winning super-resolution microscopy provides nanoscale imaging capabilities, but surprisingly there have been no substantive efforts to design fluorescent sensors that are compatible with this cutting-edge technology. In this project, new fluorescent super-resolution sensors will be developed that enable nanoscale visualisation of amyloid assemblies. These chemical and biochemical studies will establish rational design strategies to develop fluorescent sensors for super-resolution imaging applications and significantly advance our understanding of fundamental differences functional and toxic protein assemblies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101627
Funder
Australian Research Council
Funding Amount
$447,625.00
Summary
Developing ultra adsorbent MOF composites as high performance materials. This project aims to improve the adsorption properties of porous materials through enhancing their selectivity and also creating new composites. This research expects to extend application opportunities to encompass real-life scenarios, in particular hydrogen transfer and carbon capture. Expected outcomes is the enhancement of the adsorbent properties of these porous materials, and an improvement of their selectivity and m ....Developing ultra adsorbent MOF composites as high performance materials. This project aims to improve the adsorption properties of porous materials through enhancing their selectivity and also creating new composites. This research expects to extend application opportunities to encompass real-life scenarios, in particular hydrogen transfer and carbon capture. Expected outcomes is the enhancement of the adsorbent properties of these porous materials, and an improvement of their selectivity and mechanical robustness. This is due to the synergistic strengthening effects of new graphene and nanodiamond composites. The benefit of this research is in bridging the gap between porous material synthesis and industrial application, contributing to Australia's becoming a world leader in clean energy research.Read moreRead less
Functional polymeric nanopores from cyclic peptide templates. This research programme will develop nanotubes prepared through the self-assembly of cyclic peptide/polymer conjugates into functional devices for applications as nanopores. The project will establish the fundamental knowledge required to develop these materials into nanoporous polymeric films and transmembrane channels. The research programme will establish new synthetic routes to the conjugates, ascertain the technique of assembly i ....Functional polymeric nanopores from cyclic peptide templates. This research programme will develop nanotubes prepared through the self-assembly of cyclic peptide/polymer conjugates into functional devices for applications as nanopores. The project will establish the fundamental knowledge required to develop these materials into nanoporous polymeric films and transmembrane channels. The research programme will establish new synthetic routes to the conjugates, ascertain the technique of assembly into nanotubes, with a particular focus on improving the precision with which we achieve structural control, and explore the use of the nanotubes to design nanopores, for applications in the manufacture of nanoporous materials, as antibiotic agents and as biosensors.Read moreRead less
Polymer-functionalised nanotubes: controlled formation by self-assembly. This project will develop new structures of nanotubes by combining peptide sequences and synthetic polymers. These nanostructured materials will form the basis of a wide range of technological applications, such as inorganic nanotubes, ion channels, drug carriers, and more broadly in nanotechnology and nanomedicine.
Complex nano-systems for highly selective imaging and targeting of cells. The aim of the project is to design multi-functional nanoparticles that can be tracked by multiple bio-imaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography imaging. The nanoparticles are designed to be targetable to specific cell populations and capable of delivering drugs. The project plans to concentrate the MRI-active gadolinium into nanoparticles to generate enhanced images, and ....Complex nano-systems for highly selective imaging and targeting of cells. The aim of the project is to design multi-functional nanoparticles that can be tracked by multiple bio-imaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography imaging. The nanoparticles are designed to be targetable to specific cell populations and capable of delivering drugs. The project plans to concentrate the MRI-active gadolinium into nanoparticles to generate enhanced images, and to combine this with other imaging modalities to facilitate tracking and sensitivity. Expected outcomes would enable a new approach to extremely accurate and sensitive imaging of tumours to enable the imaging of much smaller tumours than currently possible. This would allow early therapeutic intervention. The nanoparticles are also designed to deliver a therapeutic payload to specific locations, avoiding systemic delivery of toxic anticancer drugs.Read moreRead less
Design of multimodal polymeric nanoparticles as targeted carriers for the co-delivery of therapeutic molecules. This project will greatly enhance the tools available to oncologists by providing new treatment options, minimising side-effects to conventional chemotherapy approaches. In this project, the design of next generation of drug delivery will be developed using the most recent advances in materials sciences.
Emergent properties in spin crossover materials. This project aims to develop ‘intelligent’ materials in which emergent properties arise due to the strategic combination of spin switching with other functionalities. Spin crossover is a versatile form of molecular switch which can reversibly change structure, colour and magnetism using convenient external stimuli. In probing new and interesting forms of interplay between technologically relevant properties, this work addresses the science of host ....Emergent properties in spin crossover materials. This project aims to develop ‘intelligent’ materials in which emergent properties arise due to the strategic combination of spin switching with other functionalities. Spin crossover is a versatile form of molecular switch which can reversibly change structure, colour and magnetism using convenient external stimuli. In probing new and interesting forms of interplay between technologically relevant properties, this work addresses the science of host-guest and electronic/magnetic systems and could lead to materials worthy of commercial development to underpin a range of future high-level technologies spanning low energy separations, molecular sensing, data storage, and electronic/magnetic/optical device componentry.Read moreRead less