Biomolecular activity modulated by interaction with nanostructures. Nanotechnological methods are able to reliably fabricate artificial nanostructures with dimensions similar to those of large biomolecules (a few to tens of nanometers). This study focuses on the interaction of artificial nanostructures with biomolecules such as proteins and DNA, and will enable scientists to better understand biomolecular recognition and binding events, which are central to all biological processes. The underst ....Biomolecular activity modulated by interaction with nanostructures. Nanotechnological methods are able to reliably fabricate artificial nanostructures with dimensions similar to those of large biomolecules (a few to tens of nanometers). This study focuses on the interaction of artificial nanostructures with biomolecules such as proteins and DNA, and will enable scientists to better understand biomolecular recognition and binding events, which are central to all biological processes. The understanding gained can then be used to design biomimetic surfaces for use in health monitoring and medical diagnostic devices with improved sensitivity, robustness and portability, thereby providing significant benefits to the health sector.Read moreRead less
Special Research Initiatives - Grant ID: SR0354588
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Integrated Nanoscale Biosystems Network (INBN). The INBN will integrate high-priority research, already identified by the ARC, in materials nanoscience and engineering with nanoscale biology. The INBN will provide the means to consolidate world-class multidisciplinary Australian research groups in existing Centres of Excellence, including several Federation Fellows, into a nanobiotechnology focus. The significant outcomes of INBN are the critical mass of outstanding researchers in the nanobiosci ....Integrated Nanoscale Biosystems Network (INBN). The INBN will integrate high-priority research, already identified by the ARC, in materials nanoscience and engineering with nanoscale biology. The INBN will provide the means to consolidate world-class multidisciplinary Australian research groups in existing Centres of Excellence, including several Federation Fellows, into a nanobiotechnology focus. The significant outcomes of INBN are the critical mass of outstanding researchers in the nanobiosciences, facilitation of innovative research to produce novel intellectual property and provision of pathways into collaborative research with international scientists and industry, and the training and development of the next generation scientists for this emerging discipline.
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Engineering and Assembly of Bioinspired Nanostructured Materials. Scientific and technological advances at the frontiers of nano- and bio-technology are poised to revolutionise healthcare and medicine. This project will involve the design, synthesis and engineering of functional biopolymer building blocks. These 'smart' biopolymers will then be assembled into responsive, nanostructured materials for targeted drug delivery and biosensing applications. These materials are expected to ultimately ha ....Engineering and Assembly of Bioinspired Nanostructured Materials. Scientific and technological advances at the frontiers of nano- and bio-technology are poised to revolutionise healthcare and medicine. This project will involve the design, synthesis and engineering of functional biopolymer building blocks. These 'smart' biopolymers will then be assembled into responsive, nanostructured materials for targeted drug delivery and biosensing applications. These materials are expected to ultimately have health benefits for Australian citizens and contribute to the development of a robust Australian nanobiotechnology industry. The project will also provide excellent opportunities for the development of outstanding young scientists and will foster exciting, multidisciplinary collaborations.Read moreRead less
ARC Centre of Excellence - Australian Centre for Electromaterials Science. The Centre will tackle some of the biggest challenges facing society: those of renewable energy, sustainable industries and enhancing human health. Improvements in all these areas are possible by developing electromaterials with improved efficiency in the generation and transfer of electrical charge. By developing new nano-materials and new theories to explain their behaviour, the Centre will make advances in the areas ....ARC Centre of Excellence - Australian Centre for Electromaterials Science. The Centre will tackle some of the biggest challenges facing society: those of renewable energy, sustainable industries and enhancing human health. Improvements in all these areas are possible by developing electromaterials with improved efficiency in the generation and transfer of electrical charge. By developing new nano-materials and new theories to explain their behaviour, the Centre will make advances in the areas of human health through the regeneration of damaged nerves (eg. in spinal injury) and development of artificial muscles; in renewable energy (plastic solar cells, lightweight batteries and electronic textiles) and in sustainable industries (recovery of precious metals and new corrosion protection technologies).Read moreRead less
New Biomimetic Nanostructured Coatings for Hip Implants. Over 30,000 hip implants operations take place in Australia each year, due largely to a significant and growing proportion of the population suffering from conditions such as osteoporosis. The coating on the implants, required to cause good bone ingrowth and adhesion between bone and implant, is far from perfect. We propose to spray coatings which mimic the structure of bone, and thus offer improved mechanical properties such as appropriat ....New Biomimetic Nanostructured Coatings for Hip Implants. Over 30,000 hip implants operations take place in Australia each year, due largely to a significant and growing proportion of the population suffering from conditions such as osteoporosis. The coating on the implants, required to cause good bone ingrowth and adhesion between bone and implant, is far from perfect. We propose to spray coatings which mimic the structure of bone, and thus offer improved mechanical properties such as appropriate rigidity and toughness, and stimulate better bone growth at the interface. In this way the implant should be much longer lasting and the need for undesirable revision surgery reduced. The processing technique proposed could also be a useful platform coating technology in a number of other industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989341
Funder
Australian Research Council
Funding Amount
$690,000.00
Summary
Advanced NanoBiomaterials Imaging Facility. The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and function on the nanometre scale. However, the small length scales involved in nanomaterials present challenges in their characterisation, and in turn, their interaction with biological systems. The Advanced NanoBiomaterials Imaging Facility will provide state-of-the-art equipment for examining the properties of nan ....Advanced NanoBiomaterials Imaging Facility. The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and function on the nanometre scale. However, the small length scales involved in nanomaterials present challenges in their characterisation, and in turn, their interaction with biological systems. The Advanced NanoBiomaterials Imaging Facility will provide state-of-the-art equipment for examining the properties of nanomaterials and their interaction with biosystems. The equipment will facilitate the development of new materials that are expected to underpin advances in drug delivery, diagnostics and implant devices, further strengthening Australia's strong reputation in these areas.Read moreRead less
Synthesis and Functionalisation of Advanced Polymer Films and Particles. Scientific and technological advances at the frontiers of nano- and biotechnology are poised to revolutionise the scope of treatment and healthcare options. This project will involve the synthesis of engineered polymer building blocks with the capability for multifunctional and intelligent response. These smart polymers will then be assembled into responsive nanostructured materials for drug delivery and biosensing applica ....Synthesis and Functionalisation of Advanced Polymer Films and Particles. Scientific and technological advances at the frontiers of nano- and biotechnology are poised to revolutionise the scope of treatment and healthcare options. This project will involve the synthesis of engineered polymer building blocks with the capability for multifunctional and intelligent response. These smart polymers will then be assembled into responsive nanostructured materials for drug delivery and biosensing applications. These materials are expected to have health benefits for Australian citizens and will contribute to a world-leading nanobiotechnology industry. The project will also provide development opportunities for young scientists and will also foster multidisciplinary collaborations within both Australia and abroad.Read moreRead less
Bacterial cell behaviour in micro/nano-confined environments. The project aims to progress the understanding of the mechanisms of marine bacteria biofilm formation and surface-modulated metabolic response. We will adjust the surface characteristics of photopolymers (as ?model? surfaces) and probe the bacterial response to surfaces, passively with micro/nano-fabricated structures and Atomic Force Microscopy; and actively with optical manipulation of single cells. The results will contribute to th ....Bacterial cell behaviour in micro/nano-confined environments. The project aims to progress the understanding of the mechanisms of marine bacteria biofilm formation and surface-modulated metabolic response. We will adjust the surface characteristics of photopolymers (as ?model? surfaces) and probe the bacterial response to surfaces, passively with micro/nano-fabricated structures and Atomic Force Microscopy; and actively with optical manipulation of single cells. The results will contribute to the fundamental knowledge regarding central biological phenomena -down to single-cell processes- as well as on applied knowledge regarding the manufacturing of antimicrobial surfaces that mimic natural bactericide processes, with larger implications on biomedical practice, and environmental, civil, mining and manufacturing industrial applications.Read moreRead less
Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the ....Advanced micro-architecture and nanotopography for enhanced tissue growth in scaffolds. Tissue engineering scaffolds offer an urgently needed synthetic biomaterials solution to overcome disease transmission from donor transplants. This work will combine biomaterial chemistry and designed surface topography to trigger bone formation within a scaffold for the first time in the world. Collaboration with national research leaders on stem cell and animal testing of the new scaffolds will provide the necessary interdisciplinary approach to generate a new product for patients in need of bone regeneration. Australia will benefit from the contribution to medical science, the development of a new device for rapid prototyping tissue engineering scaffolds, retain biomaterials research expertise, and generate new biomedical products.Read moreRead less
Nanoscale Coating and Biomodification of Colloids for Biological Applications. The research entails the preparation of novel biofunctional colloids of nanometer to micrometer dimensions and their utilisation in biological applications. Self-assembly processes will be exploited to achieve nanoscale biomodification of technologically important colloid particles, including latex beads and rare earth and semiconductor nanoparticles. The studies conducted will generate fundamental knowledge pertainin ....Nanoscale Coating and Biomodification of Colloids for Biological Applications. The research entails the preparation of novel biofunctional colloids of nanometer to micrometer dimensions and their utilisation in biological applications. Self-assembly processes will be exploited to achieve nanoscale biomodification of technologically important colloid particles, including latex beads and rare earth and semiconductor nanoparticles. The studies conducted will generate fundamental knowledge pertaining to the underlying factors that govern the formation of biofunctional colloid particles through self-assembly. This is essential for the development of tailored colloids that will meet the demands placed on nanomaterials synthesis and performance by nanotechnology. The colloids prepared will find new applications in medicine, biocatalysis and bioassays.Read moreRead less