How Language Develops, What Goes Wrong, And Why It Matters: Following The Early Language In Victoria Study To Age 13
Funder
National Health and Medical Research Council
Funding Amount
$857,242.00
Summary
One in five children start school with low language. Little is known about the long term effects on developmental, educational attainment and other outcomes later in life. In this landmark study we will track the children's language, literacy and wellbeing from ages 8 to 12 years. We will capture the children's ability as they finish their primary school education and prior to the crucial transfer to high school.
The Contribution Of Home Language Exposure To Intergenerational Transmission Of Inequality
Funder
National Health and Medical Research Council
Funding Amount
$1,281,706.00
Summary
The amount of language stimulation from parent to child could be the key driver behind intergenerational inequality. Children learn language through social interaction and this study will significantly enhance our current understanding of exposure to language in the child's home environment. The study will demonstrate how inequalities in the early years have far reaching consequences for later health and development.
Examining The Impact Of Language Reclamation On Social And Emotional Well Being Among The Barngarla
Funder
National Health and Medical Research Council
Funding Amount
$1,111,633.00
Summary
Indigenous Australians are at high risk of experiencing mental illness. For many, it is the loss of land, culture, and identity that are causes of ill health. The Barngarla people of South Australia seek to reclaim their language due to its potential reinvigorating cultural identity and wellbeing. This offers a unique opportunity to document the links between language reclamation and wellness in Aboriginal people for the first time.
A Novel Molecular Mechanism Controlling Myelopoiesis
Funder
National Health and Medical Research Council
Funding Amount
$878,439.00
Summary
The immune system is comprised of many different cell types, each with a specialised function. Many are short-lived and must be continually replenished throughout life. Abnormalities in this process underlie many human diseases, including immunodeficiency, autoimmunity and cancer. We have discovered a novel molecular mechanism that is critical for the production of immune cells. This project will investigate how this mechanism is controlled and the impacts on myelodysplastic syndromes.
Biofocussed Prostate Cancer RadioTherapy (BiRT): A Personalised Approach To Delivering The Right Dose To The Right Place
Funder
National Health and Medical Research Council
Funding Amount
$753,565.00
Summary
We propose a new approach to treating prostate cancer with radiotherapy to move from the standard whole prostate treatment to a personalised treatment that varies radiation intensity throughout the prostate. We will mathematically combine features that influence radiotherapy effect from advanced imaging, clinical and biopsy information. This model will map out the radiotherapy dose required at each part of the prostate, to maximise killing of the cancer whilst minimising harm to normal tissue
A Stem Cell-specific MicroRNA-independent Function Of Drosha
Funder
National Health and Medical Research Council
Funding Amount
$637,702.00
Summary
Stem cells are responsible for producing and replenishing the ~200 specialised cell types in our body. Our goal is to understand the molecular switches that control the function of these cells. We recently discovered that the activity of certain genes within stem cells is controlled by degradation. This degradation is absolutely crucial for safeguarding the function of stem cells. This project will investigate how this novel mechanism is controlled within these cells.
Next Generation Brain-Machine Interface: Minimally-Invasive Endovascular Stent-Electrode Array For Robotic Limb Control
Funder
National Health and Medical Research Council
Funding Amount
$1,735,574.00
Summary
Persons affected by quadriplegia and hemiplegia from stroke and spinal cord injury have few treatment options. Brain Machine Interfaces (BMIs) reconnect brain to a prosthetic limb, bypassing damaged nervous system. Our group has developed a BMI that can be implanted minimally-invasively, inside a blood vessel within the brain. We propose to evaluate this device in animal studies, and continue on to a human clinical trial pilot study. The aim is to restore mechanical control over the physical env ....Persons affected by quadriplegia and hemiplegia from stroke and spinal cord injury have few treatment options. Brain Machine Interfaces (BMIs) reconnect brain to a prosthetic limb, bypassing damaged nervous system. Our group has developed a BMI that can be implanted minimally-invasively, inside a blood vessel within the brain. We propose to evaluate this device in animal studies, and continue on to a human clinical trial pilot study. The aim is to restore mechanical control over the physical environment for a paralysed patient.Read moreRead less