Discovery Early Career Researcher Award - Grant ID: DE170101514
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations ....The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations are controlled. Understanding neuroplasticity is vital for learning, memory and healthy ageing throughout life.Read moreRead less
Disease in endangered species: The importance of multiple-host infection and spatial structure. Pathogens are increasingly recognised as threats to endangered species. Managing such threats requires models to assess alternative strategies. Most current models deal with a single host and single pathogen, without spatial structure, although multiple-host pathogens pose the greatest conservation threats. This project develops a new generation of spatially-structured multiple-host models, and applie ....Disease in endangered species: The importance of multiple-host infection and spatial structure. Pathogens are increasingly recognised as threats to endangered species. Managing such threats requires models to assess alternative strategies. Most current models deal with a single host and single pathogen, without spatial structure, although multiple-host pathogens pose the greatest conservation threats. This project develops a new generation of spatially-structured multiple-host models, and applies them to two case studies. The first is the chytrid fungus that is thought to have lead to widespread declines and extinctions of frogs in Australia and overseas. The second is birdpox and malaria that have led to the extinction and endangerment of much of Hawaii's endemic avifauna.Read moreRead less
Integrated biological control of Sclerotinia minor root rot of pyrethrum crops. Tasmania is a major global supplier of natural pyrethrum, producing 25% of the world's requirements. However the industry has a major problem with Sclerotinia minor, current chemical treatment being expensive and providing limited effectiveness. The aim of this project is to develop long term integrated control measures for this disease, particularly by the application of biological control agents targeting S. minor ....Integrated biological control of Sclerotinia minor root rot of pyrethrum crops. Tasmania is a major global supplier of natural pyrethrum, producing 25% of the world's requirements. However the industry has a major problem with Sclerotinia minor, current chemical treatment being expensive and providing limited effectiveness. The aim of this project is to develop long term integrated control measures for this disease, particularly by the application of biological control agents targeting S. minor at planting. It will also examine possible break-crops biocidal to the fungus, and other integrated control measures. The significance/outcomes will be improved crop productivity to the industry, improved competitiveness with overseas producers and reduced dependence on chemical pesticides.Read moreRead less
An integrated tool for informing pest management: modelling range shifts for an invasive vertebrate in response to climate change. Invasive species and climate contribute directly to loss of biodiversity and economic productivity. This research project focuses on providing user-orientated tools that enable a strategic approach to European rabbit management and vertebrate pest control in Australia in response to anticipated climate and land-use change.
Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia ....Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia from invasive diseases. There is an urgency to undertake our research because global environmental change and increasing movements of people (particularly military personnel) from overseas regions where these diseases are endemic is increasing the vulnerability of northern Australia to the (re)establishment of mosquito borne diseases.Read moreRead less
Investigating the genetic basis for heterogeneous susceptibility of Tasmanian devils to a novel infectious cancer. This project will use genetics and modelling to reveal why Tasmanian devils in northwest Tasmania are not dying from facial tumour disease, a new, unusual infectious cancer threatening this iconic carnivore with extinction. This project will predict extinction risk, develop management options, and provide a new template for managing emerging wildlife diseases.
Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala ....Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala care centres, wildlife hospitals and government departments.Read moreRead less
Ecology, impacts and management of wild dogs in urbanising coastal landscapes of the wet tropics, Queensland. All management agencies and local governments in north Queensland identify wild dogs as a significant threat and a complex problem for management, and are in the process of developing wild dog management plans. However, these plans tend to be reactive and short-term, because too little is known to develop effective long-term management strategies. This project will provide a sound basis ....Ecology, impacts and management of wild dogs in urbanising coastal landscapes of the wet tropics, Queensland. All management agencies and local governments in north Queensland identify wild dogs as a significant threat and a complex problem for management, and are in the process of developing wild dog management plans. However, these plans tend to be reactive and short-term, because too little is known to develop effective long-term management strategies. This project will provide a sound basis for the development of such strategies. The results of the study will also inform wild dog management in many other parts of Australia that face similar problems.Read moreRead less
Ecological-epidemiological models of feral swamp buffalo control in northern Australia. This research is locally, nationally and internationally significant because it 1) improves the capacity of the Northern Territory and its traditional aboriginal owners to manage together this prevalent species in an effort to minimise disturbance to native flora and fauna and to understand the long-term implications of continued proliferation, 2) provides a nationally relevant system to monitor and project t ....Ecological-epidemiological models of feral swamp buffalo control in northern Australia. This research is locally, nationally and internationally significant because it 1) improves the capacity of the Northern Territory and its traditional aboriginal owners to manage together this prevalent species in an effort to minimise disturbance to native flora and fauna and to understand the long-term implications of continued proliferation, 2) provides a nationally relevant system to monitor and project the spread of disease through feral animal populations in Australia, and 3) combines quantitative data and robust analytical tools that can be used as a template for solving many broad-scale feral animal problems around the world.Read moreRead less
Can Tasmanian Devils survive by adapting to devil facial tumour disease? This research will examine whether or not Tasmanian Devils are capable of adapting fast enough to survive the disease epidemic caused by a new contagious cancer, devil facial tumour disease, and evade extinction. Outcomes will determine long-term management responses to the disease and will set a benchmark for managing wildlife diseases worldwide.