An autonomously controlled ankle exoskeleton for gait rehabilitation. This project addresses a critical problem in gait rehabilitation; predicting unstable locomotion and designing interventions to augment limb-joint function. The project will develop an autonomous ankle-foot assistive device to actively increase ground clearance when high-risk foot trajectory is detected. Using wearable sensor data, machine learning algorithms will predict high-risk gait and compute an actuator-induced ankle to ....An autonomously controlled ankle exoskeleton for gait rehabilitation. This project addresses a critical problem in gait rehabilitation; predicting unstable locomotion and designing interventions to augment limb-joint function. The project will develop an autonomous ankle-foot assistive device to actively increase ground clearance when high-risk foot trajectory is detected. Using wearable sensor data, machine learning algorithms will predict high-risk gait and compute an actuator-induced ankle torque to maintain safe foot-ground clearance. A wearable autonomous joint-actuation system will contribute significantly to rehabilitation across a range of gait-impaired populations. The project's scientific and technological innovations will provide the opportunity for future developments in assistive technologies. Read moreRead less
Ocular Motility In Autism And Asperger S Disorder: Dissociation Of Motor Deficits.
Funder
National Health and Medical Research Council
Funding Amount
$131,235.00
Summary
We will use ocular motor technology to investigate motor dysfunction in autism and Asperger's disorder, to advance our understanding of the neurobiological bases of these disorders. This will help clarify whether neural networks are differentially disrupted in these disorders, as our previous clinical research suggests. This dissociation and the subsequent development of an ocular motor clincal screen may improve diagnosis, and potentially treatment, of these devastating conditions.
Influence of athletic footwear on lower limb biomechanics of pubertal girls. This project aims to determine whether athletic footwear with appropriate design features can help improve neuromuscular control and, in doing so, reduce the potentially deleterious forces on the knee and lower limb structures of pubertal girls. As girls reach puberty, they become less able to control the movement patterns of their lower limbs, particularly in high-demand tasks like running and jumping. Better-designed ....Influence of athletic footwear on lower limb biomechanics of pubertal girls. This project aims to determine whether athletic footwear with appropriate design features can help improve neuromuscular control and, in doing so, reduce the potentially deleterious forces on the knee and lower limb structures of pubertal girls. As girls reach puberty, they become less able to control the movement patterns of their lower limbs, particularly in high-demand tasks like running and jumping. Better-designed footwear for pubertal girls may improve movement patterns, decrease the likelihood of musculoskeletal injury and improve physical activity participation rates. Project outcomes may lead to the development of such footwear, and are also anticipated to expand our understanding of female developmental biomechanics.Read moreRead less
Athletic footwear for reducing knee loads in girls and women. This project aims to develop a novel athletic shoe that can reduce harmful knee loads during sport in adolescent girls and young women. As girls reach puberty, they become less able to control the movement patterns of their knees and lower limbs - particularly in high-demand tasks like jumping. The project will develop a new ASICS shoe that will be ‘field-tested’ during sporting activity with high ACL injury risk (netball) to evaluate ....Athletic footwear for reducing knee loads in girls and women. This project aims to develop a novel athletic shoe that can reduce harmful knee loads during sport in adolescent girls and young women. As girls reach puberty, they become less able to control the movement patterns of their knees and lower limbs - particularly in high-demand tasks like jumping. The project will develop a new ASICS shoe that will be ‘field-tested’ during sporting activity with high ACL injury risk (netball) to evaluate its effect on tibial shock (in-field surrogate measure of knee load) and player comfort compared to a conventional shoe. Expected outcomes include reduced healthcare costs associated with the treatment of serious knee injury, including surgical reconstruction and early-onset knee osteoarthritis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100042
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
Multitasking effects on motor control in childhood through adolescence. This project aims to increase knowledge on the development of motor control and its cognitive determinants. The ability to perform cognitive and motor tasks simultaneously is a critical skill for daily living. From childhood to adolescence, and across a range of developmental disorders, simultaneous performance of cognitive and motor tasks represents a major challenge. Children with cognitive and motor coordination problems ....Multitasking effects on motor control in childhood through adolescence. This project aims to increase knowledge on the development of motor control and its cognitive determinants. The ability to perform cognitive and motor tasks simultaneously is a critical skill for daily living. From childhood to adolescence, and across a range of developmental disorders, simultaneous performance of cognitive and motor tasks represents a major challenge. Children with cognitive and motor coordination problems show increased inattention, hyperactivity, psychosocial difficulties and negative perceptions of self-worth. This project aims to investigate how the cognitive demands of balance control during walking changes from childhood to adolescence. The results may help to identify the mechanisms underlying childhood disorders associated with comorbid cognitive and motor impairments and provide strategies for earlier identification.Read moreRead less
Discovering Patterns using Near Unsupervised Leaning to Support the Quick Detection of New Animal Disease Outbreaks Caused by Viruses. Without the capability to identify and study the vast majority of extant viruses using traditional laboratory techniques, emerging threats to Australian livestock health cannot be efficiently diagnosed or treated. New approaches based on high-throughput sequencing have recently been developed to study such viruses, but making sense of the sequence data is still a ....Discovering Patterns using Near Unsupervised Leaning to Support the Quick Detection of New Animal Disease Outbreaks Caused by Viruses. Without the capability to identify and study the vast majority of extant viruses using traditional laboratory techniques, emerging threats to Australian livestock health cannot be efficiently diagnosed or treated. New approaches based on high-throughput sequencing have recently been developed to study such viruses, but making sense of the sequence data is still a complex problem. Together with the project's Partner Organisations, including YourGene Biosciences Australia and the CSIRO Australian Animal Health Laboratory, this project aims to develop new computational methods to broaden the scope of detection and analysis of unknown viruses, enhancing the capability for research into the causative viral agents of animal diseases.Read moreRead less
Understanding influences on physical activity and sedentary behaviour from preschool to preadolescence. While promotion of optimal levels of physical activity and sedentary behaviours during childhood is important for health, much remains unknown in this field. This study will extend an existing cohort of children, recruited at ages three to five years and followed up at six to eight years by reassessing these children at nine to eleven years. Novel additions to the cohort include long term foll ....Understanding influences on physical activity and sedentary behaviour from preschool to preadolescence. While promotion of optimal levels of physical activity and sedentary behaviours during childhood is important for health, much remains unknown in this field. This study will extend an existing cohort of children, recruited at ages three to five years and followed up at six to eight years by reassessing these children at nine to eleven years. Novel additions to the cohort include long term follow-up spanning preschool to preadolescence, application of an ecological framework, and collection of objective neighbourhood data using a Geographical Information System. Findings will provide important information for policy and interventions focused at the individual, family and neighbourhood level, to improve physical activity and sedentary behaviour levels across childhood.Read moreRead less
Providing children with a healthy start to life: promoting physical activity and reducing sedentary behaviours during early childhood. Early childhood (0-5 yrs), when health behaviours develop and may track into later life, represents promise as a time to positively impact physical activity and sedentary behaviour. Yet study of these behaviours in 3-5 yr olds is only emerging, and is almost non-existent in younger children. This project aims to understand predictors of these behaviours using a s ....Providing children with a healthy start to life: promoting physical activity and reducing sedentary behaviours during early childhood. Early childhood (0-5 yrs), when health behaviours develop and may track into later life, represents promise as a time to positively impact physical activity and sedentary behaviour. Yet study of these behaviours in 3-5 yr olds is only emerging, and is almost non-existent in younger children. This project aims to understand predictors of these behaviours using a suite of longitudinal studies, including objective measures, and will commence as early as 3-mths of age. It will study strategies for promoting physical activity and reducing sedentary behaviours during early childhood, by investigating mechanisms of behaviour change in existing interventions to inform new strategies with potential to provide children with a healthy start to life.Read moreRead less
Using Stem Cells And Bioengineered Scaffolds To Promote Regeneration Following Necrotic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$710,857.00
Summary
A number of injuries, including stroke, result in tissue loss. Consequently promoting repair will require restoration of tissue structure, replacement cells and a supportive environment to promote integration of these new cells. This study will engineer and develop novel scaffolds that can replace tissue whilst additionally providing physical and chemical support for newly implanted stem cells. This work will be conducted in an animal model of stroke.
Standardising Protocols For The Differentiation And Integration Of Human Pluripotent Stem Cell-derived Neural Transplants In Parkinson's Disease
Funder
National Health and Medical Research Council
Funding Amount
$987,664.00
Summary
Clinical trials have shown that transplanting dopamine neurons (specific nerve cells) into the brain of Parkinson’s disease patients can improve symptoms. Trials use fetal tissue for implantation, which is unsustainable and highly variable. This proposal will examine stem cells as an alternative. We will establish a reliable protocol to instruct human stem cells to become dopamine neurons, develop methods to select these cells and, examine the integration of these transplanted cells in the brain