ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the ....ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the core activities of the Network: Researcher Mobility, Workshops and Conferences, Postgraduate Education, and Knowledge Management Systems. The Network is expected to add significant value to pre-existing investments and raise the profile of Australian telecommunications research.Read moreRead less
Low-energy electro-photonics: novel materials, devices and systems. This project aims to develop low-power technologies for programming and tuning photonic integrated circuits (PICs). By replacing thermal tuning, the project will reduce power consumption from watts to milliwatts, which also eliminates the thermal crosstalk that limits the complexity of today's PICs. The expected outcome will be the basis for a generic field-programmable photonic chip, which can be used to rapidly prototype desig ....Low-energy electro-photonics: novel materials, devices and systems. This project aims to develop low-power technologies for programming and tuning photonic integrated circuits (PICs). By replacing thermal tuning, the project will reduce power consumption from watts to milliwatts, which also eliminates the thermal crosstalk that limits the complexity of today's PICs. The expected outcome will be the basis for a generic field-programmable photonic chip, which can be used to rapidly prototype designs for production as full custom chips as part of a new Australian industry capability. The expected benefits will be a faster innovation cycle, greater adoption of photonic technologies, and support of research into, for example, neuromorphic optical processing, and advanced communications and sensing systems.Read moreRead less
Determination Of Irradiation Dose Efficacy For Use In Impaction Grafting At Revision Joint Replacement
Funder
National Health and Medical Research Council
Funding Amount
$411,517.00
Summary
Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence ....Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence of early complications of this procedure have included loss of fixation within the bone. Fracture of the bone around prostheses has also reported in some centres. These events require more surgery, putting the patient at higher risk greater complications and longer rehabilitations. Recent improvements in surgical technique and donor bone preparation have improved results. A current debate questions whether the dose of irradiation can be reduced from 25 kGy, while maintaining sterility of allografts. The risk of bacterial contamination in allografts is low, and irradiation reduces the mechanical strength of the graft, contributing to complications when irradiated bone is used. The benefits of decontaminating the bone may be outweighed by the higher risk for failure due to poor bone quality and resulting prosthesis instability. We will use ISO standards to test the validity of radiation dose for sterilising bone ex vivo. In the absence of controlled human studies, our aim is also to compare the results of impaction grafting with non-irradiated bone versus bone irradiated at current doses used by Australian bone banks, and lower doses indicated by ex vivo testing. We will use a large animal model of revision hip replacement, with precise measures of prosthesis stability. The results of this study will guide clinical decisions regarding the efficacy of current bone graft preparation procedures and the use of irradiated bone in human hip replacement surgery.Read moreRead less
Collaborative Sensing and Learning for Maritime Situational Awareness. We aim to demonstrate coordinated autonomous sensing of naval assets in dynamic maritime environments, reducing the operational load required to deliver a high quality maritime situational awareness. A realistic simulation based approach will help us develop novel artificial intelligence technology including: self-adaptive strategies for dynamic asset allocation, embedded smart sensing capabilities for naval observation syste ....Collaborative Sensing and Learning for Maritime Situational Awareness. We aim to demonstrate coordinated autonomous sensing of naval assets in dynamic maritime environments, reducing the operational load required to deliver a high quality maritime situational awareness. A realistic simulation based approach will help us develop novel artificial intelligence technology including: self-adaptive strategies for dynamic asset allocation, embedded smart sensing capabilities for naval observation systems and novel approaches to continuous collaborative learning from multi-spectral media. In addition to the emerging partnership between participants, the project will advance sovereign capability to develop maritime intelligence gathering technology for the Royal Australian Navy to underpin stability in our region. Read moreRead less
Switching Dynamics Approach for Distributed Global Optimisation . This project aims to create a breakthrough switching dynamics approach and new technology to speed up finding optimal solutions. It will develop a distributed switching dynamics based optimisation scheme for global optimisation problems in industrial big-data environments where timely decision making is required. It will result in a practical technology for industry optimisation problems such as economic energy dispatch in smart g ....Switching Dynamics Approach for Distributed Global Optimisation . This project aims to create a breakthrough switching dynamics approach and new technology to speed up finding optimal solutions. It will develop a distributed switching dynamics based optimisation scheme for global optimisation problems in industrial big-data environments where timely decision making is required. It will result in a practical technology for industry optimisation problems such as economic energy dispatch in smart grids and optimal charging and discharging tasks in a large network of electric vehicles, helping Australian power industry improve efficiency and security, as well as training the next generation scientists and engineers for Australia in this emerging field.Read moreRead less
Multiobjective Memetic Algorithms for Multi-task Symbolic Regression. This project aims at developing the new generation of symbolic regression methods using a yet unexplored way to represent mathematical functions. We will use memetic algorithms to create mathematical models for symbolic regression. Our memetic computing approach will be data-driven and will use multi-objective optimization and multi-task evolutionary computation for symbolic regression, addressing a core need of many areas of ....Multiobjective Memetic Algorithms for Multi-task Symbolic Regression. This project aims at developing the new generation of symbolic regression methods using a yet unexplored way to represent mathematical functions. We will use memetic algorithms to create mathematical models for symbolic regression. Our memetic computing approach will be data-driven and will use multi-objective optimization and multi-task evolutionary computation for symbolic regression, addressing a core need of many areas of science and technology. A large number of datasets will be investigated to benchmark the new methods. The expected outcomes will help support our national priorities with new data analytic capabilities. With a strong and interdisciplinary team in three continents, the project will attract international collaboration. Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100040
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
High performance electron microprobe analyser optimised for the microanalysis of sulphides and heavy elements. Understanding the chemistry of materials at micrometre scale is critical for deciphering the geological history of rocks, measuring the mobility of heavy metals in the environment and optimising the liberation of metals from ores. This new electron microprobe facility will provide more accurate results than was possible with previous instruments while increasing throughput.
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561229
Funder
Australian Research Council
Funding Amount
$518,427.00
Summary
Establishment of a Multiphoton Microscope Imaging Platform for Live Cell and Tissue, and Optical Imaging. This proposal seeks to establish a multidisciplinary multiphoton imaging laboratory, expanding the imaging capabilities of a Core Regional Imaging Facility. This Facility supports researchers across all Monash campuses and hospital-based research Schools, as well as outside research groups in the Victorian region. Furthermore, this equipment will support significant fiber optic research at V ....Establishment of a Multiphoton Microscope Imaging Platform for Live Cell and Tissue, and Optical Imaging. This proposal seeks to establish a multidisciplinary multiphoton imaging laboratory, expanding the imaging capabilities of a Core Regional Imaging Facility. This Facility supports researchers across all Monash campuses and hospital-based research Schools, as well as outside research groups in the Victorian region. Furthermore, this equipment will support significant fiber optic research at Victoria University for the development of communication and endoscopic technology. The instrument design will allow multiple use of the lightsource and choice of specific imaging devices (microscopes) to ensure that applications in biocellular imaging, intravital microscopy and fiber optic design and imaging are individually optimised.Read moreRead less