Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.
Special Research Initiatives - Grant ID: SR0354675
Funder
Australian Research Council
Funding Amount
$20,000.00
Summary
Australian Communications Research Network (ACoRN). Information and Communication Technology is a key contributor to national productivity and growth. ACoRN aims to stimulate creativity, innovation and breakthrough science, leading to technological advancement in telecommunications. The focus is on development of fundamental theories for application to emerging wired and wireless communications technologies. Specific objectives include consolidation of existing linkages; facilitation of multidis ....Australian Communications Research Network (ACoRN). Information and Communication Technology is a key contributor to national productivity and growth. ACoRN aims to stimulate creativity, innovation and breakthrough science, leading to technological advancement in telecommunications. The focus is on development of fundamental theories for application to emerging wired and wireless communications technologies. Specific objectives include consolidation of existing linkages; facilitation of multidisciplinary research; formation of new links; stimulation of commercial activity; improved post-graduate education; and increased International prominence. Our current vision involves a range of programs including: undergraduate occupational training, postgraduate internships, national and international visiting programs, and seed funding for collaborative proposals.Read moreRead less
ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the ....ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the core activities of the Network: Researcher Mobility, Workshops and Conferences, Postgraduate Education, and Knowledge Management Systems. The Network is expected to add significant value to pre-existing investments and raise the profile of Australian telecommunications research.Read moreRead less
Special Research Initiatives - Grant ID: SR0567321
Funder
Australian Research Council
Funding Amount
$184,781.00
Summary
Real-time Very Long Baseline Interferometry. We will develop a range of software products that are required to implement real-time very long baseline interferometry with the Australia long baseline array. These developments build upon substancial recent infrastructure investments and will place Australia at the forefront of this field. They will enhance our capacity to participate in international collaborations in a range of sciences including astrophysics, spacecraft tracking and geodetic mo ....Real-time Very Long Baseline Interferometry. We will develop a range of software products that are required to implement real-time very long baseline interferometry with the Australia long baseline array. These developments build upon substancial recent infrastructure investments and will place Australia at the forefront of this field. They will enhance our capacity to participate in international collaborations in a range of sciences including astrophysics, spacecraft tracking and geodetic monitoring.Read moreRead less
Mechanisms Underlying Growth, Lineage Commitment And Differentiation Of Liver Progenitor Cells
Funder
National Health and Medical Research Council
Funding Amount
$535,333.00
Summary
Liver disease is a serious health problem. Viral hepatitis, obesity and alcohol can result in end-stage liver disease. Organ transplant is the only treatment available. A widening gap between organ donations and recipients mandates alternative treatments are developed. Cell transplantation and artificial liver devices are alternatives which can use liver progenitor cells. We will investigate how factors grow and convert them into liver cells for treating liver disease patients.
Postviral Wheezing In Childhood: Disregulation Of Airway Tone?
Funder
National Health and Medical Research Council
Funding Amount
$577,040.00
Summary
Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. Ho ....Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. However, many infants who wheeze with viral infections, especially in the first year of life, do not develop allergies in later life, raising the possibility that they did not have the same type of asthma as those whose symptoms persist. This project will study the effects of viral infections on lung function to determine whether particular types of virus can have detrimental effects of lung function lasting for years. We will also examine whether the age at which the infection occurs and the severity of the infection influence the long-term outcome. The project involves studying infants during the recovery phase of respiratory viral infections, older children years after documented infections and experimental animal models that have been infected under controlled conditions. By determining whether respiratory viral infections can have long-term effects on lung function that can mimic asthma, we will advance our understanding of how asthma develops. In addition, specific treatment and preventative strategies could then be developed to prevent these long-term abnormalities, instead of relying on asthma medication (especially inhaled corticosteroids) as is the current practice. Preventative strategies could include encouraging the development of specific vaccines.Read moreRead less
The Role Of The Zinc Finger Transcriptional Repressor Znf238 During Nerve Cell Maturation
Funder
National Health and Medical Research Council
Funding Amount
$394,264.00
Summary
Proper foetal brain assembly is critical for brain function, but the underlying genetic mechanisms remain poorly defined. In this study, I will investigate a family of proteins that “turn on” neural gene expression in combination with another protein that “turns off” their expression during nerve cell development. Understanding this novel on/off mechanism for controlling gene expression in newborn nerve cells will further our understanding of how the brain is assembled.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. Th ....Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. The success of this project will further enhance the international competitiveness of Australian research in this important field and will benefit any Australian industry and business where software systems are deeply-rooted, such as transportation, smart homes, medical devices, defence and finance.Read moreRead less
Optimum Multi-rate Filter Bank Design for Speech Enhancement and Communication Systems. Multi-rate signal processing is gaining more and more importance in signal processing applications such as echo cancellation, microphone arrays, speech enhancement and equalisation. This project is aimed at obtaining high performance and high efficiency multi-rate processing designs by developing appropriate problem formulations based on solid mathematical foundations so that powerful optimisation techniques ....Optimum Multi-rate Filter Bank Design for Speech Enhancement and Communication Systems. Multi-rate signal processing is gaining more and more importance in signal processing applications such as echo cancellation, microphone arrays, speech enhancement and equalisation. This project is aimed at obtaining high performance and high efficiency multi-rate processing designs by developing appropriate problem formulations based on solid mathematical foundations so that powerful optimisation techniques can be applied. The developed multi-rate systems will result in low complexity and low power hardware implementations without significant compromise in performance in each application. Size and cost sensitive of communication devices such as personal data assistants, mobile telephones, hands-free devices, and laptops will benefit greatly from the outcome of the project.Read moreRead less