Nucleophilic carbenes as organocatalysts for asymmetric synthesis. Chemical compounds which come in two chiral mirror images (enantiomers) can have very different biological function. Often one form can have beneficial effects while the other can cause great harm (such as birth defects in the case of thalidomide). It is therefore very important for the drug industry to have asymmetric chemical reactions that lead specifically to only one enantiomer. The asymmetric reactions in this project ha ....Nucleophilic carbenes as organocatalysts for asymmetric synthesis. Chemical compounds which come in two chiral mirror images (enantiomers) can have very different biological function. Often one form can have beneficial effects while the other can cause great harm (such as birth defects in the case of thalidomide). It is therefore very important for the drug industry to have asymmetric chemical reactions that lead specifically to only one enantiomer. The asymmetric reactions in this project have been used previously to synthesise the anti-cancer metabolite roseophilin. The results of this project will ensure that there are many more similar success stories in the pharmaceutical and biotechnology industries.Read moreRead less
Island Perspective: A critical examination into Tasmania's internationally recognised regional identity through the contribution of its contemporary studio furniture, 1970-2003. Contemporary studio furniture in Tasmania has a leading national reputation, and international recognition. This project will investigate the practice of the best of contemporary Tasmanian studio furniture to interpret its social and economic history as a reflection on an island culture. The outcomes will be a consolida ....Island Perspective: A critical examination into Tasmania's internationally recognised regional identity through the contribution of its contemporary studio furniture, 1970-2003. Contemporary studio furniture in Tasmania has a leading national reputation, and international recognition. This project will investigate the practice of the best of contemporary Tasmanian studio furniture to interpret its social and economic history as a reflection on an island culture. The outcomes will be a consolidated body of unique, hitherto undocumented knowledge from the 1970s to the present, which explores identity and place throught the diversity of individual design philosophy and furniture production. The significance of this knowledge will be its contributuon towards a dialogue between political, cultural and environmental positions on an island identity within a global context.Read moreRead less
Environmental Education and Marine Ecosystem Degradation: The Role of Site-specific Art as Communicative Strategy within Community Awareness-raising Programs. This project investigates a potential application of art as a medium of environmental education. In the context of a World Fish Center sustainable community fisheries project in Vietnam's Mekong Delta, we will deploy works of fine art specifically to communicate ideas and values concerning marine ecosystem degradation. An experienced ecolo ....Environmental Education and Marine Ecosystem Degradation: The Role of Site-specific Art as Communicative Strategy within Community Awareness-raising Programs. This project investigates a potential application of art as a medium of environmental education. In the context of a World Fish Center sustainable community fisheries project in Vietnam's Mekong Delta, we will deploy works of fine art specifically to communicate ideas and values concerning marine ecosystem degradation. An experienced ecological artist will project the issue into the public domain via large-scale video and trans-media installations. Visitor interviews will assess the impact of various modes of visual communication. We believe that visual communication can assist the development of environmental responsibility by shifting perceptions and is, then, of considerable policy value.Read moreRead less
Coinage metal nanoclusters: synthesis, structure and reactivity. Metal catalysts play important roles in the multi-billion dollar production of many industrial and fine chemicals used in wide-ranging applications including pharmaceuticals, insecticides and polymers. Despite the importance of metal catalysed reactions, the molecular details of such processes remain poorly understood. Breakthrough studies highlight that reactions previously thought to be catalysed by discrete metal catalysts are i ....Coinage metal nanoclusters: synthesis, structure and reactivity. Metal catalysts play important roles in the multi-billion dollar production of many industrial and fine chemicals used in wide-ranging applications including pharmaceuticals, insecticides and polymers. Despite the importance of metal catalysed reactions, the molecular details of such processes remain poorly understood. Breakthrough studies highlight that reactions previously thought to be catalysed by discrete metal catalysts are in fact catalysed by metal nanoclusters. This project involves the application of advanced mass spectrometric and computational methods to explore the formation and reactivity of copper, silver and gold nanoclusters. Identification of key reactive intermediates will inform the design of next generation catalysts.Read moreRead less
A Midas touch for electrophiles in new reaction development. This project aims to address the lack of knowledge about how high-value organic molecules are formed in gold-catalysed reactions by advancing a novel mode of catalysis. This project expects to generate new knowledge about these gold-catalysed reactions using an innovative, interdisciplinary approach incorporating computational and synthetic techniques. Expected outcomes of this project include the optimisation and development of import ....A Midas touch for electrophiles in new reaction development. This project aims to address the lack of knowledge about how high-value organic molecules are formed in gold-catalysed reactions by advancing a novel mode of catalysis. This project expects to generate new knowledge about these gold-catalysed reactions using an innovative, interdisciplinary approach incorporating computational and synthetic techniques. Expected outcomes of this project include the optimisation and development of important organic reactions and enhancing collaboration nationally and internationally between computational and synthetic chemists. This should provide significant benefits in the form of improved chemical reactions for chemists to prepare new pharmaceuticals, agrochemicals and materials.Read moreRead less
Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in sit ....Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in situ. This will enable the control of stereochemistry in photoredox reactions – not possible with standard catalysts - and establish other useful synthetic transformations. These strategies will make it easier to prepare valuable classes of organic molecules – efficiently, safely, and cost-effectively.
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Choice models for learning and memory. Life is filled with familiar choices that often require quick decisions about objects in the environment and the contents of memory. This project examines how we learn to make rapid and accurate choices and how we quickly asses the level of confidence we have in recognition decisions based on our memories.
A new route to linear alpha olefins - catalytic isomerisation of internal olefins. Linear alpha olefins are an extremely important class of chemical building blocks used for everyday consumer products, such as plastics, detergents and lubricants. This research aims to develop a new platform technology for the production of these materials from low cost precursors.
Upgrading of light gas-to-liquid products to fuels and chemicals. The conversion of natural gas to liquid fuels (gasoline and diesel) is seen as an important alternative to crude oil refining in Australia, and a new industry based around this is likely to emerge in the coming years. This project aims to develop methods by which some of the less valuable by-products can be upgraded to fuels and chemicals.
The Shifting Locus of Artistic Practice: A survey and critical analysis of solo exhibitions in Australian public galleries, 1970-2000. The aim of this research project is to provide a critical analysis of the monographic solo survey exhibition and its significance as a primary mode of representation of the career development of Australian artists since the late 1960s. A suite of six thematically linked monographic exhibitions of mid- to late- career artists will be the focus and primary output o ....The Shifting Locus of Artistic Practice: A survey and critical analysis of solo exhibitions in Australian public galleries, 1970-2000. The aim of this research project is to provide a critical analysis of the monographic solo survey exhibition and its significance as a primary mode of representation of the career development of Australian artists since the late 1960s. A suite of six thematically linked monographic exhibitions of mid- to late- career artists will be the focus and primary output of the research. The goal will be to develop an innovative curatorial model to account for the oeuvre of the selected artists within the context of institutional developments in Australian art and culture in the late twentieth and early twenty-first century.Read moreRead less