Discovery Early Career Researcher Award - Grant ID: DE170101514
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations ....The control of neuroplasticity in the brain. This project aims to determine how neuroplasticity – the brain’s ability to remodel and make new circuits – is controlled in both excitatory and inhibitory neurons. This capacity, vital for all cognitive functions, diminishes as people age. It is imperative to determine neuroplasticity’s mechanisms and how and why they change, but it is not known how both excitatory and inhibitory neurons contribute to neuroplasticity and how these dynamic alterations are controlled. Understanding neuroplasticity is vital for learning, memory and healthy ageing throughout life.Read moreRead less
Identification Of Novel Regulatory Factors In Midbrain Development To Improve Cell Therapies For The Treatment Of Parkinson’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Cell transplantation is one of the most promising therapeutic strategies for the treatment of Parkinson’s disease. Cells are transplanted directly into the brain of the patient and can compensate for those lost to the disease. In this project we are identifying new genes that regulate the normal development of the transplanted cells in mice. We hope to use this knowledge to improve the reliability and effectiveness of the approach, bringing the therapy closer to the clinic.
Identifying Malingered Posttraumatic Stress Disorder: Biological Markers for Legal Assessment. Posttraumatic stress disorder (PTSD) is the most common psychiatric disorder that is claimed in compensation claims in Australia. There are currently no reliable means to distinguish malingered from genuine PTSD. This project aims to develop the most accurate means of identifying malingered PTSD by using the most recent technology to index biological responses, including fMRI, in participants with PT ....Identifying Malingered Posttraumatic Stress Disorder: Biological Markers for Legal Assessment. Posttraumatic stress disorder (PTSD) is the most common psychiatric disorder that is claimed in compensation claims in Australia. There are currently no reliable means to distinguish malingered from genuine PTSD. This project aims to develop the most accurate means of identifying malingered PTSD by using the most recent technology to index biological responses, including fMRI, in participants with PTSD, without PTSD, and malingered PTSD. This study will lead to a biological assessment that can objectively index PTSD and be resistant to intentional feigning. These data will significantly enhance legal assessments of PTSD and facilitate compensation resolution.Read moreRead less
Spontaneous activity and neural decoding in the developing brain. This project aims to investigate how patterns of neural activity emerge in the developing brain, using the zebrafish as a model system. This project expects to generate new knowledge regarding the functional significance of spontaneously generated activity, and how it interacts with sensory experience. The expected outcomes of this project include enhanced capacity at the interface between neuroscience and computation. This should ....Spontaneous activity and neural decoding in the developing brain. This project aims to investigate how patterns of neural activity emerge in the developing brain, using the zebrafish as a model system. This project expects to generate new knowledge regarding the functional significance of spontaneously generated activity, and how it interacts with sensory experience. The expected outcomes of this project include enhanced capacity at the interface between neuroscience and computation. This should provide significant benefits including greater insight into normal brain development, and the formulation of new concepts potentially relevant for brain-inspired computing.Read moreRead less
How does environmental enrichment affect brain development? This project aims to use brain imaging and advanced computational analyses to investigate how early sensory experience affects brain development. It adopts the larval zebrafish as a model system, since they display sophisticated behaviours from an early age, and neural activity can be recorded at whole-brain scale with single neuron resolution. The project aims to generate new knowledge regarding environmental effects on brain developme ....How does environmental enrichment affect brain development? This project aims to use brain imaging and advanced computational analyses to investigate how early sensory experience affects brain development. It adopts the larval zebrafish as a model system, since they display sophisticated behaviours from an early age, and neural activity can be recorded at whole-brain scale with single neuron resolution. The project aims to generate new knowledge regarding environmental effects on brain development and behaviour. This will provide significant benefits including greater insight into normal brain development, and the formulation of new concepts potentially relevant for brain-inspired computing. The expected outcomes also include enhanced capacity at the interface between neuroscience and computation.Read moreRead less
How do patterns of brain activity emerge during early life? This project uses theory and experiment to investigate how neural coding emerges in the developing brain. It adopts the larval zebrafish as a model system, because neural activity can be recorded at whole-brain scale but with single neuron resolution. The project expects to generate new knowledge regarding how neural activity comes to represent sensory stimuli, and new statistical models for interpreting large-scale patterns of neural a ....How do patterns of brain activity emerge during early life? This project uses theory and experiment to investigate how neural coding emerges in the developing brain. It adopts the larval zebrafish as a model system, because neural activity can be recorded at whole-brain scale but with single neuron resolution. The project expects to generate new knowledge regarding how neural activity comes to represent sensory stimuli, and new statistical models for interpreting large-scale patterns of neural activity. This will provide significant benefits including greater insight into normal brain development, and the formulation of new concepts potentially relevant for brain-inspired computing. The expected outcomes also include enhanced capacity at the interface between neuroscience and computation.Read moreRead less
Brain mechanisms for coordinating with others through sound. Distinguishing between sounds produced by self and others is critical for interpersonal coordination and communication through speech and music. This project employs a novel dual-brain electrophysiological technique with tagged audio signals to elucidate how the human brain achieves this distinction, and when and why it cannot. Expected outcomes include new knowledge on the neurophysiological mechanisms that support self-other processi ....Brain mechanisms for coordinating with others through sound. Distinguishing between sounds produced by self and others is critical for interpersonal coordination and communication through speech and music. This project employs a novel dual-brain electrophysiological technique with tagged audio signals to elucidate how the human brain achieves this distinction, and when and why it cannot. Expected outcomes include new knowledge on the neurophysiological mechanisms that support self-other processing, and the acoustic conditions and behavioural strategies that facilitate their operation. These outcomes should ultimately have applied benefits for improving interpersonal coordination and social interaction, especially in digital environments and clinical populations with atypical self-other processing.Read moreRead less
A new theory for retinotectal map formation. How brains become wired up during development is a question of
importance to both biology and computing. In this project we adopt a
novel computational approach to understanding the development of
topographic maps, a wiring pattern that is ubiquitous in biological
nervous systems. This project will build capacity for research in
computational neuroscience in Australia. It may also lead to
technological benefits such as new ideas for the design o ....A new theory for retinotectal map formation. How brains become wired up during development is a question of
importance to both biology and computing. In this project we adopt a
novel computational approach to understanding the development of
topographic maps, a wiring pattern that is ubiquitous in biological
nervous systems. This project will build capacity for research in
computational neuroscience in Australia. It may also lead to
technological benefits such as new ideas for the design of self-wiring
computing devices, and new insights into
the causes of wiring defects both during normal development and
rewiring after injury.
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Discovery Early Career Researcher Award - Grant ID: DE160101064
Funder
Australian Research Council
Funding Amount
$373,536.00
Summary
How musical rhythms entrain the human brain. This project is designed to investigate the brain mechanisms that allow humans to feel the beat in musical rhythms. Although such activity facilitates pro-social and therapeutic effects, the underlying brain mechanisms remain unknown. The project intends to examine the interface between musical rhythms, behaviour and brain activity to increase knowledge on a fundamental process of brain function: the dynamic coupling between perception and body moveme ....How musical rhythms entrain the human brain. This project is designed to investigate the brain mechanisms that allow humans to feel the beat in musical rhythms. Although such activity facilitates pro-social and therapeutic effects, the underlying brain mechanisms remain unknown. The project intends to examine the interface between musical rhythms, behaviour and brain activity to increase knowledge on a fundamental process of brain function: the dynamic coupling between perception and body movement. The project aims to provide insight into how psychological, environmental and neural mechanisms affect entrainment to rhythmic events and inform practices for education and clinical rehabilitation.Read moreRead less
Psychological and neurophysiological mechanisms underlying human interaction in musical contexts. Human interaction in musical groups is a culturally widespread activity that showcases the remarkable capacity for precision and creativity in interpersonal coordination. Although such activity has beneficial effects, including the facilitation of prosociality and positive therapeutic outcomes, the psychological and neurophysiological mechanisms that underpin an individual’s ability to coordinate wi ....Psychological and neurophysiological mechanisms underlying human interaction in musical contexts. Human interaction in musical groups is a culturally widespread activity that showcases the remarkable capacity for precision and creativity in interpersonal coordination. Although such activity has beneficial effects, including the facilitation of prosociality and positive therapeutic outcomes, the psychological and neurophysiological mechanisms that underpin an individual’s ability to coordinate with others remain poorly understood. This project aims to investigate these mechanisms by examining relationships between behaviour, social factors, and brain structure and function in naturalistic and laboratory settings. This will inform the assessment and treatment of clinical conditions that affect movement timing and social interaction.Read moreRead less