Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
PrtFII, A Streptococcus Pyogenes Fibronectin Binding Protein, And Invasive Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$296,540.00
Summary
Our recent work revealed that, in the Aboriginal population, young age is a risk factor for severe invasive diseases caused by group A streptococcus. For group A streptococcus infection to occur, bacterial attachment is the first step. The bacterium attaches to host cells through interactions involving host fibronectin and the pathogen's fibronectin-binding proteins. We have found that streptococcal strains from severe disease cases are more likely to have the gene for PrtFII, a fibronectin bind ....Our recent work revealed that, in the Aboriginal population, young age is a risk factor for severe invasive diseases caused by group A streptococcus. For group A streptococcus infection to occur, bacterial attachment is the first step. The bacterium attaches to host cells through interactions involving host fibronectin and the pathogen's fibronectin-binding proteins. We have found that streptococcal strains from severe disease cases are more likely to have the gene for PrtFII, a fibronectin binding protein, than those from uncomplicated skin sores. In this application we propose to extend this observation and compare biochemical properties of PrtFII from strains belonging to the above two sets of collections. We hypothesise that PrtFII from invasive strains bind to fibronectin more tightly than the proteins from strains that cause uncomplicated infection. We also will test whether sera from invasive disease cases have lower titre of antibodies to the conserved region of PrtFII than sera from uncomplicated cases. A streptococcal vaccine by necessity has to be a multi-component vaccine to cover a wide spectrum of diseases and epidemiological differences. The study proposed here may provide a basis to argue whether or not to include PrtFII in such a multi-component vaccine.Read moreRead less
Radiation and Ablation in Rapidly Expanding Flows. The aim of the project is to record the spectra of radiation from a region of rapidly expanding flow representative of the passage of the shock layer on a re-entry capsule from the windward to the leeward surfaces. The significance of this work is that it addresses a critical area of spacecraft where the uncertainties of our design techniques are of the order of 300 per cent in terms of surface heat transfer, and current vehicles have to use lar ....Radiation and Ablation in Rapidly Expanding Flows. The aim of the project is to record the spectra of radiation from a region of rapidly expanding flow representative of the passage of the shock layer on a re-entry capsule from the windward to the leeward surfaces. The significance of this work is that it addresses a critical area of spacecraft where the uncertainties of our design techniques are of the order of 300 per cent in terms of surface heat transfer, and current vehicles have to use large safety factors to ensure survivability. The outputs from the project will be a data base of radiative parameters which should enable accurate models of the flow to be developed, which is expected to facilitate the design of advanced spacecraft with greater safety and reliability, and with lower structural mass.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100263
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Magnetohydrodynamic aerobraking to land heavy payloads on Mars. This project aims to decelerate space vehicles by applying a magnetic field to the hot ionised gases that form around the vehicle. In the thin atmosphere of Mars, aerodynamic drag alone is not enough to land a spacecraft larger than 1 tonne. A human mission to Mars requires landing of payloads up to 80 tonnes. Interaction of the magnetic field with the ionised flow dissipates kinetic energy and can reduce surface heating. This proje ....Magnetohydrodynamic aerobraking to land heavy payloads on Mars. This project aims to decelerate space vehicles by applying a magnetic field to the hot ionised gases that form around the vehicle. In the thin atmosphere of Mars, aerodynamic drag alone is not enough to land a spacecraft larger than 1 tonne. A human mission to Mars requires landing of payloads up to 80 tonnes. Interaction of the magnetic field with the ionised flow dissipates kinetic energy and can reduce surface heating. This project could make Mars-return missions feasible by enabling greatly increased payloads. It also aims to evaluate magnetohydrodynamic braking and heat mitigation at true flight conditions.Read moreRead less
Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass a ....Non-equilibrium reacting shock layers. This project aims is to study the non-equilibrium aerodynamic processes involved in hypervelocity flight. The design of vehicles for high speed flight is critically dependent on modelling the interactions between the flow field and the airframe, and the current lack of understanding is restricting the scope and benefit of viable activities in space. The expected outcomes include the ability to design optimised heat shields and air-frames with minimum mass and maximum payload, precisely targeting specific flight conditions and vehicle shapes. The prospective benefits include increased productivity and reliability and reduced cost of missions to and from space, and a proliferation of new applications which this understanding will facilitate.Read moreRead less
Turbulent heat transfer during Mars Venus and Earth atmospheric entry. This project aims to design better heat shields for spacecraft. Designing heat shields for re-entry vehicles needs good models to predict aerodynamic heating. Conventional wind tunnels cannot measure aerodynamic heating in ground tests in the region of peak heating, making design uncertain and risky. This project will use a free-piston-driven expansion tunnel that can produce flows fast and dense enough to measure heating for ....Turbulent heat transfer during Mars Venus and Earth atmospheric entry. This project aims to design better heat shields for spacecraft. Designing heat shields for re-entry vehicles needs good models to predict aerodynamic heating. Conventional wind tunnels cannot measure aerodynamic heating in ground tests in the region of peak heating, making design uncertain and risky. This project will use a free-piston-driven expansion tunnel that can produce flows fast and dense enough to measure heating for turbulent boundary layers at the highest speeds encountered during re-entry. This should allow scientists to test and develop theoretical and numerical models of heating and so improve spacecraft design.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100849
Funder
Australian Research Council
Funding Amount
$364,000.00
Summary
Advanced thermal protection systems to enable Mars return missions. This project aims to advance the modelling of spacecraft heat shield performance to enable future returns to Earth from Mars, where vehicles will encounter heating loads an order of magnitude higher than Lunar returns. Survival depends on sacrificial heat shields which intentionally lose mass through ablation to form a protective layer. Currently, this process cannot be predicted accurately leading to compromised safety, excessi ....Advanced thermal protection systems to enable Mars return missions. This project aims to advance the modelling of spacecraft heat shield performance to enable future returns to Earth from Mars, where vehicles will encounter heating loads an order of magnitude higher than Lunar returns. Survival depends on sacrificial heat shields which intentionally lose mass through ablation to form a protective layer. Currently, this process cannot be predicted accurately leading to compromised safety, excessive weight, and increased mission cost. The expected outcome is an ablation model for vehicle design which, for the first time, is based on experiments with a realistic aerodynamic flow. The significance and benefit of this project is its potential to make ambitious missions such as a Mars return feasible.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100373
Funder
Australian Research Council
Funding Amount
$447,320.00
Summary
The role of resource fluctuations in structuring microbial communities. The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. Drawing on emerging theory and a tight integration of modelling and experiments in a model microbial system, this project aims to investigate the impact of modified nutrient regimes on the structure and stability of ecological communities. This project expec ....The role of resource fluctuations in structuring microbial communities. The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. Drawing on emerging theory and a tight integration of modelling and experiments in a model microbial system, this project aims to investigate the impact of modified nutrient regimes on the structure and stability of ecological communities. This project expects to generate new knowledge at the forefront of research into diversity maintenance, ecosystem functioning and higher-order interactions. The outcomes should provide a deep mechanistic understanding of microbial community dynamics, with applications from animal health to environmental flows and insect pest management.Read moreRead less
Ablative thermal protection systems. The project will study ablative reentry heat shields by experiments simulating hypervelocity atmospheric flight. The results will enable the design of the advanced spacecraft which are needed to extend mans exploration of the universe. Data will be validated by comparison with flights such as the Japanese Hayabusa asteroid sample return mission.