Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453608
Funder
Australian Research Council
Funding Amount
$579,230.00
Summary
Multifunctional confocal laser scanning microscope with time resolved and two photon imaging and fluorescence correlation capabilities. We seek to establish an Australian first confocal laser scanning microscope with time resolved imaging and fluorescence correlation spectroscopy capabilities. Its advantages include ultrasensitive detection of weak fluorescent emissions against high autofluorescent background by using fluorescence lifetime signatures, with over three orders of magnitude discrimi ....Multifunctional confocal laser scanning microscope with time resolved and two photon imaging and fluorescence correlation capabilities. We seek to establish an Australian first confocal laser scanning microscope with time resolved imaging and fluorescence correlation spectroscopy capabilities. Its advantages include ultrasensitive detection of weak fluorescent emissions against high autofluorescent background by using fluorescence lifetime signatures, with over three orders of magnitude discrimination improvement. The system will also be able to monitor binding of single molecules. These techniques will open new and exciting avenues for interdisciplinary research at the frontier between biological and physical sciences. The microscope will operate within an existing multi-user Optical Characterisation Facility supporting research of an established network of scientists in the Sydney area.Read moreRead less
Higher cognition and hemispheric specialization in an avian species: referential and intentional communication. We will discover whether alarm calls of Australian magpies, noted for their outstanding range of vocalisations, are referential (signalling predator type and location) and intentional (vocalised in specific contexts). Such complex communication , once thought to be unique to humans, has been found in some mammals and just one avian species, the domestic chick. This project will be the ....Higher cognition and hemispheric specialization in an avian species: referential and intentional communication. We will discover whether alarm calls of Australian magpies, noted for their outstanding range of vocalisations, are referential (signalling predator type and location) and intentional (vocalised in specific contexts). Such complex communication , once thought to be unique to humans, has been found in some mammals and just one avian species, the domestic chick. This project will be the first such investigation of an avian species in its natural habitat. This is important also because bird and mammalian brains are organised differently and birds offer a unique opportunity to discover whether one hemisphere is specialised for this purpose.Read moreRead less
Novel insecticidal neurotoxins from Australian spider venoms. Insecticidal toxins have considerable potential as novel biopesticides to combat the evolution of widespread insect resistance to classical chemical pesticides. This problem is increasing both in Australia and internationally. This study aims to isolate and pharmacologically characterise potent and selective insecticidal neurotoxins from Australian arachnids. Our laboratories will isolate neurotoxins from spider venoms, determine thei ....Novel insecticidal neurotoxins from Australian spider venoms. Insecticidal toxins have considerable potential as novel biopesticides to combat the evolution of widespread insect resistance to classical chemical pesticides. This problem is increasing both in Australia and internationally. This study aims to isolate and pharmacologically characterise potent and selective insecticidal neurotoxins from Australian arachnids. Our laboratories will isolate neurotoxins from spider venoms, determine their selectivity in insect and mammal bioassays, determine their primary and tertiary structures, and investigate their structure-function relationships by electrophysiological techniques. These functional and structural data will allow the future engineering, by molecular or synthetic procedures, of viral biopesticide analogues with increased potency, stability and selectivity.Read moreRead less
Special Research Initiatives - Grant ID: SR0354500
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
- ....ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
-facilitate training in array methodologies and bioinformatics,
-co-ordinate innovation of technologies,-provide centralised data warehousing,
-provide access to automated high-level gene annotation,
-provide data mining tools,
-set standards for data management and exchangeRead moreRead less
Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid i ....Force from lipids: the role of the lipid bilayer in mechanosensory transduction. The proposed research will significantly contribute to a better understanding of the wide range of physiological processes underlying mechanosensory transduction in living cells. The direct benefit for Australian science consists of: (i) strengthening international links with leading overseas laboratories, and (ii) accessing the state-of-the-art expertise not available in Australia. The acquired knowledge will aid in developing and designing artificial tactile sensors inspired by their biological models studied in this project. Long-term, the project is expected to make an original contribution towards developing new technologies and novel medical applications, both of which promise to be of great national benefit.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237427
Funder
Australian Research Council
Funding Amount
$269,000.00
Summary
Equipment for Fluorescence-Based Cellular Analysis. The requested equipment is needed by a large grouping of highly productive researchers to carry out work across a very broad range of fields that is otherwise difficult or impossible to perform. The new equipment will facilitate obtaining many exciting and important outcomes, including identification of: (i) mechanisms controlling cell death, (ii) natural biological products that may have commercial applications (eg anti-fouling agents), (iii) ....Equipment for Fluorescence-Based Cellular Analysis. The requested equipment is needed by a large grouping of highly productive researchers to carry out work across a very broad range of fields that is otherwise difficult or impossible to perform. The new equipment will facilitate obtaining many exciting and important outcomes, including identification of: (i) mechanisms controlling cell death, (ii) natural biological products that may have commercial applications (eg anti-fouling agents), (iii) "probiotic" bacteria and vaccines that may be used to protect animals from disease, and (iv) mechanisms by which changes in human lens proteins contribute to the development of cataract.Read moreRead less
Plasticity in placental vasculature and the evolution of viviparity in lizards. This cross-disciplinary research will provide thorough understanding of the reproductive physiology of animals with different forms of reproduction, information critical for conservation and management of Australia's biodiversity. Australia's unique reptiles provide the best animal system in the world for research in this area. Our research on maternal-embryonic interactions in this animal model has direct implicatio ....Plasticity in placental vasculature and the evolution of viviparity in lizards. This cross-disciplinary research will provide thorough understanding of the reproductive physiology of animals with different forms of reproduction, information critical for conservation and management of Australia's biodiversity. Australia's unique reptiles provide the best animal system in the world for research in this area. Our research on maternal-embryonic interactions in this animal model has direct implications for understanding some medical disorders, such as human angiogenic disorders. The research will strengthen ties internationally through research in South Africa, and provide training in combined biological and medical technologies. It will maintain Australia's long-term leadership in this area of research.Read moreRead less
Special Research Initiatives - Grant ID: SR0354683
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Ocean Discovery Network. The ODN will focus research on Australia's vast marine jurisdiction by:
1. Providing a forum for developing coordinated marine research enterprises in the National Research Priority areas of biodiversity, exploitation of resources, seaway security and climate.
2. Developing innovative international research and providing a mechanism for involvement in international science programs
3. Advancing research capabilities between national and international ocean scientist ....Ocean Discovery Network. The ODN will focus research on Australia's vast marine jurisdiction by:
1. Providing a forum for developing coordinated marine research enterprises in the National Research Priority areas of biodiversity, exploitation of resources, seaway security and climate.
2. Developing innovative international research and providing a mechanism for involvement in international science programs
3. Advancing research capabilities between national and international ocean scientists with web-based data-exchange services and links to global databases
4. Facilitating the transfer of research skills to young investigators
5. Maximising multidisciplinary use of Australian ocean science capacity, particularly the National Facility Research Vessel and the RSV Aurora Australis
Read moreRead less
Evolution of viviparity in reptiles: the fundamental role of junctional complexes. This project utilises unique Australian reptile fauna to understand global questions in fundamental biology. We will discover basic biological information on native species, which will be important in future conservation of Australian ecosystems and animals and ultimately in helping to maintain Australia's biodiversity. The project also provides training opportunities for graduate and undergraduate students in ....Evolution of viviparity in reptiles: the fundamental role of junctional complexes. This project utilises unique Australian reptile fauna to understand global questions in fundamental biology. We will discover basic biological information on native species, which will be important in future conservation of Australian ecosystems and animals and ultimately in helping to maintain Australia's biodiversity. The project also provides training opportunities for graduate and undergraduate students in several different research methods that are widely applicable in the more general Australian workforce. Because the research work is genuinely cross-disciplinary research, its findings are applicable to both biological and medically oriented technologies.Read moreRead less
Determinants of metabolic rate in animals. The metabolic rate of an animal represents its fundamental "cost of living" and varies dramatically (>100-fold) between different vertebrate species. We have proposed the "membrane pacemaker theory" to explain this variation and currently this is the only mechanistic explanation of metabolic variation between species. It has received significant international interest. A species metabolic rate and its maximum lifespan are connected but the precise mecha ....Determinants of metabolic rate in animals. The metabolic rate of an animal represents its fundamental "cost of living" and varies dramatically (>100-fold) between different vertebrate species. We have proposed the "membrane pacemaker theory" to explain this variation and currently this is the only mechanistic explanation of metabolic variation between species. It has received significant international interest. A species metabolic rate and its maximum lifespan are connected but the precise mechanistic link between them is unknown. We will investigate the mechanisms underlying the "membrane pacemaker theory" as an explanation of the metabolic rates of vertebrate species and its role in the determination of maximum lifespan.Read moreRead less