Efficient Operation of Bioreactors using Nonlinear Dynamical Systems Theory. Current methods of determining optimal operating conditions in bioreactors have recently been shown to be inefficient, resulting in serious omissions of crucial parameter regions. We will use mathematical techniques from dynamical systems theory to establish a general framework by which bioreactor systems can be efficiently and systematically investigated to improve reactor performance. By communicating these results at ....Efficient Operation of Bioreactors using Nonlinear Dynamical Systems Theory. Current methods of determining optimal operating conditions in bioreactors have recently been shown to be inefficient, resulting in serious omissions of crucial parameter regions. We will use mathematical techniques from dynamical systems theory to establish a general framework by which bioreactor systems can be efficiently and systematically investigated to improve reactor performance. By communicating these results at relevant fora, we will increase the awareness within the Australian and international engineering communities of the advantages of modern mathematical techniques. Although this proposal focuses on bioreactors, the techniques can be easily adapted to improve the performances of other chemical processes.
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Analysing Instabilities in Complex Combustion Models for Different Geometrical Configurations. Anyone who has gazed into a fire will appreciate the complexity of combustion. To date only the simplest of models have been comprehensively analysed. This project, which aims to analyse more complex combustion models, will address some of the fundamental issues of combustion theory. Results from this project will lead to a better understanding of combustion processes, with the potential to prevent exp ....Analysing Instabilities in Complex Combustion Models for Different Geometrical Configurations. Anyone who has gazed into a fire will appreciate the complexity of combustion. To date only the simplest of models have been comprehensively analysed. This project, which aims to analyse more complex combustion models, will address some of the fundamental issues of combustion theory. Results from this project will lead to a better understanding of combustion processes, with the potential to prevent explosions in reactors and storage tanks. Other potential applications range from bushfires to the manufacture of exotic materials. Furthermore, the novel mathematical techniques developed in this project can be easily adapted to other types of systems such as those used in biology (eg. epidemiology and tumour growth), economics, physics etc. Read moreRead less
Decentralized Control Problems for Networked Systems. The conceptual advances to be made in the area decentralized control of networked systems.
New design rules for decentralized control in networked systems will be developed and published in the top international journals and major international conferences.
Also, a contribution of the project will be to produce high quality Ph.D. graduates in this area of control theory.
THE DEVELOPMENT OF MECHANISTIC MODELS FOR BUBBLY FLOWS WITH HEAT AND MASS TRANSFER. Commercially available CFD computer codes are currently widely used in many Australian industrial sectors. It is clearly recognised that the state-of-the-art models for dealing with complex bubbly flows with/without heat and mass transfer in these computer codes require further developments and improvements. This research project will address the prevalent deficiency in many of these computer codes. It is antici ....THE DEVELOPMENT OF MECHANISTIC MODELS FOR BUBBLY FLOWS WITH HEAT AND MASS TRANSFER. Commercially available CFD computer codes are currently widely used in many Australian industrial sectors. It is clearly recognised that the state-of-the-art models for dealing with complex bubbly flows with/without heat and mass transfer in these computer codes require further developments and improvements. This research project will address the prevalent deficiency in many of these computer codes. It is anticipated that through this major development of new models capable of predicting a wide range of industrial bubbly flow problems and implementation thereafter in these computer codes, industries will experience significant benefits especially reduce time and costs in their design and production.Read moreRead less
Experimental and Numerical Modelling of Gas-Liquid Flows. Multiphase flow systems are encountered in many process industries such as chemical, petroleum, mining, energy, food and pharmaceutical, which are fundamental to the Australian economy. Commercially available computer codes for simulating such systems are currently widely used in many Australian industrial sectors. This research project will address the prevalent deficiency in many of these computer codes and develop new models capable of ....Experimental and Numerical Modelling of Gas-Liquid Flows. Multiphase flow systems are encountered in many process industries such as chemical, petroleum, mining, energy, food and pharmaceutical, which are fundamental to the Australian economy. Commercially available computer codes for simulating such systems are currently widely used in many Australian industrial sectors. This research project will address the prevalent deficiency in many of these computer codes and develop new models capable of predicting a wide range of industrial bubbly flow problems. The resultant improved computer codes will provide industries with significant benefits - especially reduced times and costs in their design and production.Read moreRead less
Material boundaries in ultrasonics: New methods and in vitro studies in biomedical phantoms. Ultrasound is an indispensable part of healthcare worldwide. The next wave of applications will see ultrasound pulses used to closely probe suspected disease sites and to directly manipulate bioactive agents. For safe and effective use of such techniques it is essential to know the ultrasound field at the disease site. This project will develop simulation methods to achieve the fast, accurate and case-sp ....Material boundaries in ultrasonics: New methods and in vitro studies in biomedical phantoms. Ultrasound is an indispensable part of healthcare worldwide. The next wave of applications will see ultrasound pulses used to closely probe suspected disease sites and to directly manipulate bioactive agents. For safe and effective use of such techniques it is essential to know the ultrasound field at the disease site. This project will develop simulation methods to achieve the fast, accurate and case-specific results required. Community healthcare will benefit, through better diagnostic capabilities and customized treatment. Australia is well placed to profit further from this research, in view of the growing worldwide demand for more sophisticated, knowledge-based techniques in medicine.Read moreRead less
The effect of vessel wall structures on ultrasonic flow velocity measurements. The flow velocity within a nearly cylindrical vessel is often measured using an external ultrasound transducer via the Doppler principle. Thick vessel walls may present acoustically mismatched structures. This project aims to determine how such walls redistribute the energy in an interrogating ultrasound beam, and how this in turn affects the measurement of flow velocities. This is a fundamental issue, especially imp ....The effect of vessel wall structures on ultrasonic flow velocity measurements. The flow velocity within a nearly cylindrical vessel is often measured using an external ultrasound transducer via the Doppler principle. Thick vessel walls may present acoustically mismatched structures. This project aims to determine how such walls redistribute the energy in an interrogating ultrasound beam, and how this in turn affects the measurement of flow velocities. This is a fundamental issue, especially important in vascular disease where blood flow and blood vessels are affected by wall irregularities and lesions. The new knowledge generated by this project will have practical importance and, by identifying achievable outcomes, potentially major cost savings, in medical ultrasound.Read moreRead less
Diffusion driven pattern formation and signal propagation in spatially complex excitable media. A basic understanding of the mechanisms for pattern formation, from the spots on leopards to electrical signalling of neurons, has been achieved through reaction-diffusion equations. However to obtain a complete understanding, which is vital for many applications, it is necessary to modify this mathematical model to incorporate spatial complexities in the underlying media. This project will develop ....Diffusion driven pattern formation and signal propagation in spatially complex excitable media. A basic understanding of the mechanisms for pattern formation, from the spots on leopards to electrical signalling of neurons, has been achieved through reaction-diffusion equations. However to obtain a complete understanding, which is vital for many applications, it is necessary to modify this mathematical model to incorporate spatial complexities in the underlying media. This project will develop a fractional calculus framework for pattern formation, including signal propagation, in spatially complex and excitable media. In a particular application we will model the way in which the signalling properties of neurons depend critically on their spatial complexity.Read moreRead less
3D Structure determination of biomacromolecular assemblies from sparse data. This project has direct impact on pharmaceutical research: Biomacromolecular interactions are key points for pharmaceutical intervention and detailed structural knowledge of dynamic protein interactions can significantly accelerate drug development. Australia has invested in expensive instrumentation that can be used with new laboratory methods to obtain information on delicately balanced biomacromolecular interactions, ....3D Structure determination of biomacromolecular assemblies from sparse data. This project has direct impact on pharmaceutical research: Biomacromolecular interactions are key points for pharmaceutical intervention and detailed structural knowledge of dynamic protein interactions can significantly accelerate drug development. Australia has invested in expensive instrumentation that can be used with new laboratory methods to obtain information on delicately balanced biomacromolecular interactions, and how they malfunction in disease. This project will provide a computational framework to increase the impact of this investment by integrating measurements from a range of novel technologies and developing understanding of changes in structure of large protein complexes in different functional states.Read moreRead less
Refinement of Temporal and Epistemic Specifications in Asynchronous Systems. Designing distributed systems is a complex activity requiring rigorous mathematical models of designs and specifications. It is desirable for the mathematical notations to be as close as possible to intuitive notions used by designers. One such notion is the idea that components in a distributed system have states of knowledge. Previous work has developed a calculus enabling derivation of systems with global clock by s ....Refinement of Temporal and Epistemic Specifications in Asynchronous Systems. Designing distributed systems is a complex activity requiring rigorous mathematical models of designs and specifications. It is desirable for the mathematical notations to be as close as possible to intuitive notions used by designers. One such notion is the idea that components in a distributed system have states of knowledge. Previous work has developed a calculus enabling derivation of systems with global clock by series of correctness-preserving transformations from a knowledge-based specification. This project will generalize this work to a calculus for systems that lack a global clock, and implement a tool providing automated support for use of the calculus.Read moreRead less