Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particl ....Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particle clustering. Computational modelling and experimental investigations will be undertaken to identify the heat transfer mechanisms of various nanofluids. The outcomes of the work will increase knowledge on nanofluids and offer a significant opportunity to improve the efficiency of many thermal engineering systems.Read moreRead less
A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will d ....A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will develop, whilst focused on heart tissue, will have broader applicability, and may underpin advancements in other disciplines. Finally, we expect that the software solutions and infrastructure will have both commercial and strategic value in their own right.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453911
Funder
Australian Research Council
Funding Amount
$391,529.00
Summary
Microwave Antenna Testing Facility for Far-Field and Spherical Near-Field Measurements. The proposed facility is for testing broad-beam microwave antennas (1 GHz - 18 GHz), designed and developed by collaborators for several research and commercial projects. These antennas are important in telecommunications, defence and biomedical applications. While facilitating timely pattern measurements of antenna prototypes, it will open new opportunities in antenna experimentation. This facility will enha ....Microwave Antenna Testing Facility for Far-Field and Spherical Near-Field Measurements. The proposed facility is for testing broad-beam microwave antennas (1 GHz - 18 GHz), designed and developed by collaborators for several research and commercial projects. These antennas are important in telecommunications, defence and biomedical applications. While facilitating timely pattern measurements of antenna prototypes, it will open new opportunities in antenna experimentation. This facility will enhance collaborators' highly acclaimed theoretical research by providing experimental results for theory validation. Near-field patterns available from the facility will advance our knowledge on complicated antennas. This will generate researchers skilled in state-of-the art antenna measurements, and will help develop competitive Australian industries in this frontier technology.Read moreRead less
Quantification of Traffic Generated Nano and Ultrafine Particle Dynamics and Toxicity in Transit Hubs and Transport Corridors. The socio-economic benefits to Australia will include (i) new knowledge for the multiparameter assessment of nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates (ii) a breakthrough in the scientific understanding of traffic generated particles in the urban atmosphere (iii) determining the toxicological impact of these ....Quantification of Traffic Generated Nano and Ultrafine Particle Dynamics and Toxicity in Transit Hubs and Transport Corridors. The socio-economic benefits to Australia will include (i) new knowledge for the multiparameter assessment of nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates (ii) a breakthrough in the scientific understanding of traffic generated particles in the urban atmosphere (iii) determining the toxicological impact of these particles on biological systems. The ultimate economic benefit will be improved urban design to lower human exposure to ultrafine particles, thus reducing health care cost and productivity losses. The research will also place Australia at the forefront of international progress towards better methods for achieving environmental sustainability.Read moreRead less
Fractional dynamic models for MRI to probe tissue microstructure. This project aims to develop new mathematical tools for mapping tissue microstructural properties via the use of space-time fractional calculus methods. In magnetic resonance imaging, mathematical models and their parameters play a key role in associating information between images and biology, with the overall aim of producing spatially resolved maps of tissue property variations. However, models which can inform on changes in mi ....Fractional dynamic models for MRI to probe tissue microstructure. This project aims to develop new mathematical tools for mapping tissue microstructural properties via the use of space-time fractional calculus methods. In magnetic resonance imaging, mathematical models and their parameters play a key role in associating information between images and biology, with the overall aim of producing spatially resolved maps of tissue property variations. However, models which can inform on changes in microscale tissue properties are lacking. The tools developed by this project will be used to generate new magnetic resonance image based maps to convey information on tissue microstructure changes in the human brain. Additionally, the mathematical tools developed will be transferable to other applications where diffusion and transport in heterogeneous porous media play a role.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101398
Funder
Australian Research Council
Funding Amount
$355,744.00
Summary
Quantifying the risk of groundwater contamination from hydraulic fracturing in coal seam gas operations in Australia. Concern for impacts to groundwater resources due to coal seam gas operations has led to heated debate in the community. This project will assess the risk to groundwater contamination from fracking in coal seam gas operations. It is critical that naturally occurring compounds in the coal seam and injected compounds are not mobilised to aquifers topped by water bores. This project ....Quantifying the risk of groundwater contamination from hydraulic fracturing in coal seam gas operations in Australia. Concern for impacts to groundwater resources due to coal seam gas operations has led to heated debate in the community. This project will assess the risk to groundwater contamination from fracking in coal seam gas operations. It is critical that naturally occurring compounds in the coal seam and injected compounds are not mobilised to aquifers topped by water bores. This project will build accurate, site-specific, dynamic numerical models of the hydraulic-fracturing process in coal seam gas operations. This will enable prediction of the maximum vertical extent of stimulated fractures in specific coal seams and will help establish criteria for when and where fracking in coal seam gas wells is safe in relation to groundwater contamination.Read moreRead less
Multilayer Graphene Based Anti-Corrosion Polymer Coated Structures. This project aims to develop a novel multilayer graphene/polymer coating for structures exposed to corrosive environment with graphene concentration varying layer-wise to eliminate galvanic corrosion yet maintain all unique advantages owing to graphene inclusion, thus offering a cost-effective design solution with significantly improved anti-corrosion performance and remarkably enhanced safety and durability for structures. Expe ....Multilayer Graphene Based Anti-Corrosion Polymer Coated Structures. This project aims to develop a novel multilayer graphene/polymer coating for structures exposed to corrosive environment with graphene concentration varying layer-wise to eliminate galvanic corrosion yet maintain all unique advantages owing to graphene inclusion, thus offering a cost-effective design solution with significantly improved anti-corrosion performance and remarkably enhanced safety and durability for structures. Expected outcomes of this project include an innovative design, experimental data on corrosion prevention, development of reliable simulation techniques and design procedures for the proposed coating. This should provide huge benefits to Australian civil, offshore and marine engineering industry and national economy.Read moreRead less
A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent c ....A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130100008
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Research Hub for Transforming Australia’s Manufacturing Industry through High Value Additive Manufacturing. ARC Research Hub for Transforming Australia’s Manufacturing Industry through High Value Additive Manufacturing. A world class, globally-linked and industry-focussed Research Hub will be established to underpin the uptake of metal alloy based additive manufacturing (including three-dimensional printing) in Australia. Research will cover the issues that need to be resolved for success, ....ARC Research Hub for Transforming Australia’s Manufacturing Industry through High Value Additive Manufacturing. ARC Research Hub for Transforming Australia’s Manufacturing Industry through High Value Additive Manufacturing. A world class, globally-linked and industry-focussed Research Hub will be established to underpin the uptake of metal alloy based additive manufacturing (including three-dimensional printing) in Australia. Research will cover the issues that need to be resolved for success, including the effects of non-equilibrium solidification, process optimisation to achieve quality, consistency and repeatability, and new user-friendly design tools to realise the benefit of free-form manufacturing. Real components will be studied to give immediate impact. The Research Hub will also train highly skilled people needed for this growing industry.Read moreRead less
Characterisation Of Two Novel Markers Of Osteosarcoma Metastasis As Potential Therapeutic Targets
Funder
National Health and Medical Research Council
Funding Amount
$624,500.00
Summary
Osteosarcoma (OS) is the most common bone tumour in children and adolescents. In spite of aggressive chemotherapy, OS tumours that metastasise to the lungs result in dismal long-term survivals of only 10-20%. For these patients, new treatment options are desperately needed. In this proposal we show compelling data identifying two new markers of OS metastasis. This research aims to validate the suitability of these novel markers as therapeutic targets to prevent OS metastasis.