Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The ....Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The knowledge and models developed in this project should help design and develop a microfluidic device for efficient fractionation of complex fluids into valuable components.Read moreRead less
Characterization of Fast Propagating Fires in Green Buildings. This project aims to gain a better understanding of the mechanisms of fast-propagating fires and to address the deficiency in current fire models in assessing the fire safety requirement of green buildings. Although there are many compelling advantages associated with green building designs, because they promote better natural ventilation they could pose a significant fire hazard to occupants due to the propensity of rapid fire and s ....Characterization of Fast Propagating Fires in Green Buildings. This project aims to gain a better understanding of the mechanisms of fast-propagating fires and to address the deficiency in current fire models in assessing the fire safety requirement of green buildings. Although there are many compelling advantages associated with green building designs, because they promote better natural ventilation they could pose a significant fire hazard to occupants due to the propensity of rapid fire and smoke spread within the enclosed space. The new predictive fire model in this project is expected to promote a safer and sustainable building environment.Read moreRead less
Decomposition and Duality: New Approaches to Integer and Stochastic Integer Programming. Because of their rich modelling capabilities, integer programs are widely used in industry for decision making and planning. However their solution algorithms do not have the maturity of their cousins in convex optimisation, where the theory of strong duality is ubiquitous. Efficient methods for convex optimisation under uncertainty do not apply to the integer case, which is highly non-convex. Furthermore, i ....Decomposition and Duality: New Approaches to Integer and Stochastic Integer Programming. Because of their rich modelling capabilities, integer programs are widely used in industry for decision making and planning. However their solution algorithms do not have the maturity of their cousins in convex optimisation, where the theory of strong duality is ubiquitous. Efficient methods for convex optimisation under uncertainty do not apply to the integer case, which is highly non-convex. Furthermore, integer models usually assume the data is known with certainty, which is often not the case in the real world. This project will develop new theory and algorithms to enhance the analysis of integer models, including those that incorporating uncertainty, while also enabling the use of parallel computing paradigms. Read moreRead less
Constrained and Stable Solutions of Nonlinear and Semismooth Equations. In this project, comprehensive models for designing safe power system parameters will be proposed, efficient algorthms for solving these models will be constructed. The new models and algorithms in this project will provide efficient tools to prevent catastrophic events in power systems, which is related with national security. This project will also strengthen collaboration of Australian applied
mathematians with inter ....Constrained and Stable Solutions of Nonlinear and Semismooth Equations. In this project, comprehensive models for designing safe power system parameters will be proposed, efficient algorthms for solving these models will be constructed. The new models and algorithms in this project will provide efficient tools to prevent catastrophic events in power systems, which is related with national security. This project will also strengthen collaboration of Australian applied
mathematians with international researchers and engineering scientists. This is important for the advance of science and technology in
Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453911
Funder
Australian Research Council
Funding Amount
$391,529.00
Summary
Microwave Antenna Testing Facility for Far-Field and Spherical Near-Field Measurements. The proposed facility is for testing broad-beam microwave antennas (1 GHz - 18 GHz), designed and developed by collaborators for several research and commercial projects. These antennas are important in telecommunications, defence and biomedical applications. While facilitating timely pattern measurements of antenna prototypes, it will open new opportunities in antenna experimentation. This facility will enha ....Microwave Antenna Testing Facility for Far-Field and Spherical Near-Field Measurements. The proposed facility is for testing broad-beam microwave antennas (1 GHz - 18 GHz), designed and developed by collaborators for several research and commercial projects. These antennas are important in telecommunications, defence and biomedical applications. While facilitating timely pattern measurements of antenna prototypes, it will open new opportunities in antenna experimentation. This facility will enhance collaborators' highly acclaimed theoretical research by providing experimental results for theory validation. Near-field patterns available from the facility will advance our knowledge on complicated antennas. This will generate researchers skilled in state-of-the art antenna measurements, and will help develop competitive Australian industries in this frontier technology.Read moreRead less
Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the p ....Can an anti-HIV gene in blood stem cells protect from immune depletion by HIV? Approximately 15,000 individuals in Australia are currently HIV infected. Gene therapy has the capacity to remove antiretroviral treatment related issues, dramatically decrease treatment costs and simplify treatment of HIV.
In this study we will model a new approach to treat HIV in which the patient's own cells are used as the therapy by incorporating an anti-HIV gene. These cells are then re-introduced into the patient.
The strong mathematical focus of this project, and its application to a promising approach against HIV, will place Australia at the forefront of the mathematics of gene research and contribute to the National Priority Area of Promoting and Maintaining Good Health and the Priority Goal of Preventative Healthcare.
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Non-invasive prediction of adverse neural events using brain wave activity. This project aims to develop intelligent decision-making systems for non-invasive identification of adverse neural events (fatigue/freezing of gait) through real-time monitoring of brain wave activity. Analyses of the effectiveness of the changes in physiological parameters associated with electroencephalography (EEG) signals, advanced biomedical instrumentation, and optimal computational intelligence will form a basis f ....Non-invasive prediction of adverse neural events using brain wave activity. This project aims to develop intelligent decision-making systems for non-invasive identification of adverse neural events (fatigue/freezing of gait) through real-time monitoring of brain wave activity. Analyses of the effectiveness of the changes in physiological parameters associated with electroencephalography (EEG) signals, advanced biomedical instrumentation, and optimal computational intelligence will form a basis for the development of platform technology capable of monitoring and detection of neural health status. Success is expected to yield a new generation of smart dynamic non-invasive systems that will be critical for developing effective solutions to counter life threating conditions for a large cross section of the Australian population.Read moreRead less
A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent c ....A new biomechanical model for understanding aging of stored Red Blood Cells. This project plans to develop a novel modelling framework to accurately represent the biomechanical properties of red blood cells (RBCs) over time under stored conditions. Stored RBCs suffer ageing-related deformability changes which impede RBC functions. The framework aims to integrate models for RBC membrane, inside haemoglobin and outside storage solution, and accounts for ageing effects by embedding time-dependent correlations. It should provide new insights and understanding of the mechanisms of deformability changes of RBCs during stored lifespan. Therefore, it should significantly improve blood storage industry practices in terms of improving RBC storage protocols with preventative ageing strategies.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130100008
Funder
Australian Research Council
Funding Amount
$4,000,000.00
Summary
ARC Research Hub for Transforming Australia’s Manufacturing Industry through High Value Additive Manufacturing. ARC Research Hub for Transforming Australia’s Manufacturing Industry through High Value Additive Manufacturing. A world class, globally-linked and industry-focussed Research Hub will be established to underpin the uptake of metal alloy based additive manufacturing (including three-dimensional printing) in Australia. Research will cover the issues that need to be resolved for success, ....ARC Research Hub for Transforming Australia’s Manufacturing Industry through High Value Additive Manufacturing. ARC Research Hub for Transforming Australia’s Manufacturing Industry through High Value Additive Manufacturing. A world class, globally-linked and industry-focussed Research Hub will be established to underpin the uptake of metal alloy based additive manufacturing (including three-dimensional printing) in Australia. Research will cover the issues that need to be resolved for success, including the effects of non-equilibrium solidification, process optimisation to achieve quality, consistency and repeatability, and new user-friendly design tools to realise the benefit of free-form manufacturing. Real components will be studied to give immediate impact. The Research Hub will also train highly skilled people needed for this growing industry.Read moreRead less
New Approaches to Modelling and Analysing Long-Memory Random Processes. The project aims to develop new approaches using infinite-dimensional Markov processes to solving important long-standing problems from the theory of long memory random processes and their applications. It aims to: construct a class of new representations of random processes; derive inequalities for the key numerical characteristics; and, devise and investigate numerical methods for computing the characteristics and for perf ....New Approaches to Modelling and Analysing Long-Memory Random Processes. The project aims to develop new approaches using infinite-dimensional Markov processes to solving important long-standing problems from the theory of long memory random processes and their applications. It aims to: construct a class of new representations of random processes; derive inequalities for the key numerical characteristics; and, devise and investigate numerical methods for computing the characteristics and for performing statistical inference on the long memory models. The accuracy of numerical approximations will be analysed using simulations on supercomputers. Expected outcomes include models and results of practical importance with applications such as intrusion detection problems, cell motility for biological data and telecommunication.Read moreRead less