Advancing Medical Image Analysis through High Performance Heterogeneous Computing, Numerical Simulation, and Novel Human Computer Interfaces. This project will link Australian researchers with a major multi-national IT company. The engagement of world-class personnel from Microsoft will provide unprecedented opportunities for graduate students to experience research in both an academic and an industrial setting. The participation of Microsoft product division offers the potential to transform th ....Advancing Medical Image Analysis through High Performance Heterogeneous Computing, Numerical Simulation, and Novel Human Computer Interfaces. This project will link Australian researchers with a major multi-national IT company. The engagement of world-class personnel from Microsoft will provide unprecedented opportunities for graduate students to experience research in both an academic and an industrial setting. The participation of Microsoft product division offers the potential to transform the outcomes of this project into widely-used software solutions. The project will pave the way for more widespread and reliable evidenced-based computer-aided diagnosis and image-guided treatment. It will produce well-trained and sought-after graduates and research associates with extensive inter-disciplinary knowledge of medical image analysis and high-performance computing.Read moreRead less
Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less
A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will d ....A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will develop, whilst focused on heart tissue, will have broader applicability, and may underpin advancements in other disciplines. Finally, we expect that the software solutions and infrastructure will have both commercial and strategic value in their own right.Read moreRead less
Adapting the Bulk Synchronous Parallel processing model to Peer-to-Peer Networked Computing. Advances in distributed computing have shown that data parallel and parametric applications domains are amenable to wide area distribution. The project will advance the Bulk Synchronous Parallel processing model to describe innovative applications from the loosely synchronous domain, e.g. fluid dynamics, strategy algorithms and N-body problems are challenges that have significant scientific and industria ....Adapting the Bulk Synchronous Parallel processing model to Peer-to-Peer Networked Computing. Advances in distributed computing have shown that data parallel and parametric applications domains are amenable to wide area distribution. The project will advance the Bulk Synchronous Parallel processing model to describe innovative applications from the loosely synchronous domain, e.g. fluid dynamics, strategy algorithms and N-body problems are challenges that have significant scientific and industrial value. The project specializes the exciting peer-to-peer paradigm, a frontier of inter-networking technology. By using the latest techniques and taking advantage of the technology implosion caused by low cost parallel infrastructure, the project outcomes will give Australia a strong position in the future of parallel technology.Read moreRead less
Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optim ....Control of Markov jumping processes with constraints. The project outcomes will constitute the set of tools for modelling and optimisation of complex stochastic systems and will lead to new and more precise characterisations of optimal behaviour of complex controllable systems arising in Resource Management, Engineering and Telecommunications. Therefore, the project fits to the research priority areas Breakthrough Science and Frontier Technologies in the topic of mathematical modelling and optimisation of Complex Systems.Read moreRead less
Computer Assisted Research Mathematics and its Applications. The mathematics community will benefit from infusion of new computer-assisted techniques and modalities for research and training post-graduate students, both from my pure research project and through development of an associated research centre. Ultimately, this should also help more school students learn mathematics well and so play a part in addressing Australia's skill shortage. Also, the work on optimization algorithms promises to ....Computer Assisted Research Mathematics and its Applications. The mathematics community will benefit from infusion of new computer-assisted techniques and modalities for research and training post-graduate students, both from my pure research project and through development of an associated research centre. Ultimately, this should also help more school students learn mathematics well and so play a part in addressing Australia's skill shortage. Also, the work on optimization algorithms promises to improve the performance and quality of many practical signal reconstruction methods. These are used by varied Australian industries from telecommunication to mining and by researchers in the digital arts and fields such as astronomy, physics, chemistry, bioscience, geoscience, engineering and medicine.Read moreRead less
Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will he ....Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will help to maintain high research profile of Australian researchers, to increase the capacity for consultancy and contract work, and provide a cutting-edge information technology for the Australian telecommunications industry, business and government (Priority 3 - Frontier Technologies). Read moreRead less
Implementing Feferman-Landin Logic. The objective of this project is to utilise computer based verification tools (such as PVS and Rewritting Logic) to develop a software engineering environment for specifying and verifying systems written in high-level programming languages such as Java, Scheme, and ML. The project will thus subtantially advance the use of formal computer based tools to develop reliable programs and specifications for life-critical systems. The project will also develop form ....Implementing Feferman-Landin Logic. The objective of this project is to utilise computer based verification tools (such as PVS and Rewritting Logic) to develop a software engineering environment for specifying and verifying systems written in high-level programming languages such as Java, Scheme, and ML. The project will thus subtantially advance the use of formal computer based tools to develop reliable programs and specifications for life-critical systems. The project will also develop formally
based interoperability between the PVS and Maude systems, two widely
used computer tools for reasoning about complex systems.Read moreRead less
Foundations of Executable Temporal Logic. In many computer applications, including those of temporal reasoning, distributed computations and knowledge representations, the concept of time is of central importance. Multiple granularity of time also plays a critical role as not all events are necessarily defined over a uniform model of time. This project will develop the foundations of executable logical representations, supporting multiple granularity of time. This will allow system developers a ....Foundations of Executable Temporal Logic. In many computer applications, including those of temporal reasoning, distributed computations and knowledge representations, the concept of time is of central importance. Multiple granularity of time also plays a critical role as not all events are necessarily defined over a uniform model of time. This project will develop the foundations of executable logical representations, supporting multiple granularity of time. This will allow system developers access to powerful logical techniques in those applications. In the process, fundamental problems in modelling multiple granularity of time will be identified, and application-independent solutions to those problems will be provided.Read moreRead less
Pervasive Grids with Autonomic Capabilities. A grid computing system that brings together a multitude of heterogonous resources able should be able to function continuously without much intervention by a human operator. This work aims at developing techniques and tools for the monitoring and prediction of the behaviour of the core structure of a grid. In this case, the ?core? structure is a large- or a wide-area network, or a collection of such networks. The monitoring process will feed into the ....Pervasive Grids with Autonomic Capabilities. A grid computing system that brings together a multitude of heterogonous resources able should be able to function continuously without much intervention by a human operator. This work aims at developing techniques and tools for the monitoring and prediction of the behaviour of the core structure of a grid. In this case, the ?core? structure is a large- or a wide-area network, or a collection of such networks. The monitoring process will feed into the other layers in the grid fabric important information (traffic, current and possible future congestions, failures, topological variations, etc) to enable the efficient and consistent operation of the grid. This is an important research problem in grid computing
since traditional assumptions that are more or less valid in conventional high-performance computing settings break down on the Grid.Read moreRead less