A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can ....A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can be used by engineers in Australia and France to simulate transport phenomena in porous media, which have significant environmental impact. The research will lead to publications in scientific journals and communications at national/international conferences. Research training of postdocs and PhD students is another excellent outcome of the project.Read moreRead less
Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less
Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particl ....Computational modelling of nanofluids for industrial applications. The use of nanoparticles in heat transfer fluids, then known as nanofluids, increases their specific heat and thermal conductivity. Recent experimental works highlight that anomalous transport phenomena are evident in nanofluids that cannot be adequately described by classical conservation laws. We will extend these conservation laws to incorporate fractional operators to capture the fluid memory effects and the impact of particle clustering. Computational modelling and experimental investigations will be undertaken to identify the heat transfer mechanisms of various nanofluids. The outcomes of the work will increase knowledge on nanofluids and offer a significant opportunity to improve the efficiency of many thermal engineering systems.Read moreRead less
A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will d ....A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will develop, whilst focused on heart tissue, will have broader applicability, and may underpin advancements in other disciplines. Finally, we expect that the software solutions and infrastructure will have both commercial and strategic value in their own right.Read moreRead less
From genes to organ function: understanding how heterogeneity in tissue modulates cellular behaviour in the heart. New computational and software engineering approaches are developed to model the electrophysiological variability of the heart and the mechanisms inducing arrhythmias. A significant outcome is a set of practical tools vital to cardiac research that provide medical specialists the ability to test hypotheses on low-cost powerful computing hardware.
Image-based Multiscale Modelling of Transport Phenomena in Porous Media. This project aims to develop an innovative general framework to build multiphase porous media transport models directly from electron microscope images of the underlying microstructure. Leading edge experimental, computational and applied mathematical techniques are proposed to drive this novel approach of multiscale modelling, employable across numerous fields of science and engineering. The central project theme of develo ....Image-based Multiscale Modelling of Transport Phenomena in Porous Media. This project aims to develop an innovative general framework to build multiphase porous media transport models directly from electron microscope images of the underlying microstructure. Leading edge experimental, computational and applied mathematical techniques are proposed to drive this novel approach of multiscale modelling, employable across numerous fields of science and engineering. The central project theme of developing an efficient and accurate multiscale model for simulating transport in heterogeneous porous media is expected to find application in the drying, timber and crop industries, and governmental agencies managing pollution in groundwater resources. This insight is likely to be invaluable for designing new industrial technologies and optimising current operations.Read moreRead less
Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscal ....Effective and accurate model dynamics, deterministic and stochastic, across multiple space and time scales. A persistent feature of complex systems in engineering and science is the emergence of macroscopic, coarse grained, coherent behaviour from the interactions of microscopic agents (molecules, cells, grains) and with their environment. In current modeling, ranging from ecology to materials science, the underlying microscopic mechanisms are often known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available in closed form. Our novel methodology will explore this stumbling block, and promises to radically change the modeling, exploration and understanding of multiscale complex system behaviour.Read moreRead less
Predicting strength of porous materials. This project aims to develop a predictive theory of strength for unflawed, low-ductile porous materials – an unsolved problem in computational solid mechanics. Three-dimensional printing of lightweight, porous materials is used in industry, medicine and science. The project will develop the theory and conduct experiments on porous metallic and polymeric samples made using additive manufacturing, which require understanding and optimisation of the building ....Predicting strength of porous materials. This project aims to develop a predictive theory of strength for unflawed, low-ductile porous materials – an unsolved problem in computational solid mechanics. Three-dimensional printing of lightweight, porous materials is used in industry, medicine and science. The project will develop the theory and conduct experiments on porous metallic and polymeric samples made using additive manufacturing, which require understanding and optimisation of the building of fine scale features. Understanding strength should improve design of stronger materials, by using and extending the capabilities of three-dimensional printing. These advances will further provide a much-needed basis for a fundamental understanding of fracture in other porous materials important to society such as concrete, rocks, porous ceramics and bone implants.Read moreRead less
Advanced computational techniques for micro/nano multiscale systems of NEMS/BioMEMS. The outcome of this project will have the following benefits to Australia.
1) It will improve the research level in the area of multiscale simulation of NEMS/BioMEMS;
2) The project will be beneficial to possibly establish new industries in the areas of nanotechnology as well as to make good use of today's microelectronics, mircofabrication and computer technology that have already established in Australia;
....Advanced computational techniques for micro/nano multiscale systems of NEMS/BioMEMS. The outcome of this project will have the following benefits to Australia.
1) It will improve the research level in the area of multiscale simulation of NEMS/BioMEMS;
2) The project will be beneficial to possibly establish new industries in the areas of nanotechnology as well as to make good use of today's microelectronics, mircofabrication and computer technology that have already established in Australia;
3) The manpower trained by this project in the areas of multi-scale simulation of MEMS/NEMS/BioMEMS will provide a crucial support for the future industry of Australia.
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Demonstrating Advantages of Smart Antennas in Indoor Wireless Communications Systems. The performance of indoor wireless communications systems is adversely affected by multi-path signal propagation. When the received signal drops below a certain level, the usual practice is that the receiving station requests the transmitting device to increase its output power. An adverse effect of this action is a reduced life of battery of a portable transceiver, more power being radiating towards users and ....Demonstrating Advantages of Smart Antennas in Indoor Wireless Communications Systems. The performance of indoor wireless communications systems is adversely affected by multi-path signal propagation. When the received signal drops below a certain level, the usual practice is that the receiving station requests the transmitting device to increase its output power. An adverse effect of this action is a reduced life of battery of a portable transceiver, more power being radiating towards users and an increase of interference. The aim of this project is to demonstrate an alternative method of maintaining good quality communication link. The proposed method employs a smart antenna system to mitigate adverse effects of multi-path and interference.Read moreRead less