Predicting Obstructive Sleep Apnoea Using 3D Craniofacial Photography
Funder
National Health and Medical Research Council
Funding Amount
$424,715.00
Summary
Sleep Apnoea is a common medical condition associated with snoring and collapse of the throat during sleep. Diagnosis of sleep apnoea involves an overnight sleep study in a specialised laboratory, which is expensive and time consuming. It is possible that sleep apnea could be diagnosed from a 3-dimensional photograph of the face. This study will define the relationships between sleep apnea and 3D face photographs in 956 young adults and 1,200 of their parents, and 3,000 sleep clinic patients.
Evaluating The Effect Of Morphine On Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$534,303.00
Summary
Prescription opiate poisoning deaths have increased substantially in recent years which may be worsened by population increases in obesity and related obstructive sleep apnea. However, no proper clinical trial has ever investigated the effect of an opiate on obstructive sleep apnea, which is the aim of the proposed trial. The study will be important in understanding ways to reduce opiate realted deaths and may also provide insights into new treatment methods for snoring and sleep apnea.
A Novel Optical Stimulation Method For Obstructive Sleep Apnoea Treatment
Funder
National Health and Medical Research Council
Funding Amount
$510,913.00
Summary
This project aims to develop and characterize a novel optogenetic pharyngeal stimulation system to dilate the upper airway using a light stimulus. This will provide proof-of-concept for a new minimally invasive treatment option for obstructive sleep apnoea.
Obstructive Sleep Apnoea Phenotypes And Treatment In Quadriplegia
Funder
National Health and Medical Research Council
Funding Amount
$599,635.00
Summary
Losing function in your arms and legs after an injury (quadriplegia) is a catastrophic event. Quadriplegia also results in obstructive sleep apnoea; a condition where the throat closes repeatedly while asleep causing sleepiness, poor concentration and cardiovascular diseases like stroke. Despite most people with quadriplegia having this disease, the cause is unknown. This project will thoroughly investigate obstructive sleep apnoea causes in people with quadriplegia and test a possible treatment
Clarifying The Pathogenic Role Of Arousal-hyperventilation In Obstructive And Central Sleep Apnoea: Testing Fundamental Pathophysiological Mechanisms And A Strategic New Treatment
Funder
National Health and Medical Research Council
Funding Amount
$414,717.00
Summary
This project is designed to understand the mechanisms underpinning much more stable breathing during deep sleep in obstructive sleep apnoea (OSA). A newly developed analytical technique will be used to examine breathing effort changes across sleep, and interactions with respiratory-induced awakenings in OSA patients. In addition, a new treatment designed to stabilise breathing will be tested and refined towards a new treatment option for OSA and for central sleep apnoea.
Clinical Outcomes, Safety And Incremental Cost Effectiveness Of Multi-level Airway Surgery In Patients With Moderate-severe Obstructive Sleep Apnea (OSA) Who Have Failed Medical Management
Funder
National Health and Medical Research Council
Funding Amount
$652,794.00
Summary
Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to ....Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to improved patient outcomes.Read moreRead less
The Role Of Lung Volume In The Pathogenesis And Treatment Of Obstructive Sleep Apnea.
Funder
National Health and Medical Research Council
Funding Amount
$337,691.00
Summary
Obstructive sleep apnea (OSA) is a common disorder of repetitive upper airway collapse during sleep. Reducing the volume of air in the lungs increases airway collapsibility. Lung volume is therefore likely important in OSA but has not been investigated thoroughly. Also, whether raising lung volume during sleep can be used to treat OSA is unknown. The aim of this grant is therefore to investigate the role, and therapeutic potential, of lung volume in OSA.
Predicting Treatment Response To Mandibular Advancement Splints: A Novel Biomechanical Imaging Method
Funder
National Health and Medical Research Council
Funding Amount
$689,062.00
Summary
Mandibular advancement splints are an alternative to continuous positive airway pressure for patients with Obstructive Sleep Apnoea (OSA). However, they are effective for only about half of OSA patients, and it is not currently possible to predict who will benefit. This project will explore a new magnetic resonance imaging method to see if it can predict who will respond to mandibular advancement splint therapy.
Biomechanical, Neural And Sensory Phenotyping Of The Upper Airway In Obstructive Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$746,138.00
Summary
Obstructive sleep apnoea (OSA) is a common disorder where the upper airway closes repeatedly during sleep. It results in daytime sleepiness, increased risk of accidents and cardiovascular disease. But not all patients are the same, and individually tailored treatments are needed. This project will develop new ways to identify the causes of OSA in individual patients, using new MRI imaging methods, sensory testing, and measurements of the neural activity in the muscles that keep the airway open.
Role Of Load Detection And Compensation In Pathogenesis Of Obstructive Sleep Apnea.
Funder
National Health and Medical Research Council
Funding Amount
$340,867.00
Summary
This proposal will use novel techniques to explore how defective responses to the threat posed by a collapsing upper airway contribute to the Obstructive Sleep Apnea syndrome, a disease involving repetitive collapse of the upper airway in sleep. Responses to small increases in the resistance to inspiratory airflow will be examined by measuring the small electrcal responses in the brain to these loads, and the response of the muscles responsible for maintaining airway patency to the collapsing fo ....This proposal will use novel techniques to explore how defective responses to the threat posed by a collapsing upper airway contribute to the Obstructive Sleep Apnea syndrome, a disease involving repetitive collapse of the upper airway in sleep. Responses to small increases in the resistance to inspiratory airflow will be examined by measuring the small electrcal responses in the brain to these loads, and the response of the muscles responsible for maintaining airway patency to the collapsing forces induced by these loads, in both wakefulness and sleep. The brain's response to resistive loads will also be evaluated using the techique of functional magnetic resonance imaging, which demonstrates areas of the brain activated by a stimulus.Read moreRead less