Glaucoma is the second leading cause of blindness in the world affecting approximately 70 million people. Glaucoma can occur at any age but the commonest type occurs in middle to old age. The disease has a genetic basis and can be inherited. As a result we have been studying the genetics of the disease in two large families from Tasmania. We hope to identify the genes involved in disease causation using a number of genetic techniques. Once mutations in a disease gene have been identified from af ....Glaucoma is the second leading cause of blindness in the world affecting approximately 70 million people. Glaucoma can occur at any age but the commonest type occurs in middle to old age. The disease has a genetic basis and can be inherited. As a result we have been studying the genetics of the disease in two large families from Tasmania. We hope to identify the genes involved in disease causation using a number of genetic techniques. Once mutations in a disease gene have been identified from affected individuals we will then be in a position to look for mutations in other family members and identify those individuals at risk of developing disease. Improvements in our understanding of how these genes are involved in disease causation will allow us to offer diagnostic testing to the wider community and develop better therapeutic interventions for treatment.Read moreRead less
New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray s ....New quantitative methods in X-ray imaging using crystal optics. This project will enhance Australian science's international leadership in the area of x-ray imaging. This powerful type of X-ray imaging, which makes use of optical elements made of perfect crystals, is specially tailored to image samples which are invisible to conventional x-ray techniques. Such "extended x-ray vision" is extremely important for imaging in medicine, biology and materials science. Furthermore, we will train x-ray scientists of tomorrow, whose expertise will allow Australia to capitalize on its investment in the Australian Synchrotron.Read moreRead less
Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The ....Thulium doped silica-based optical fibres - towards the realisation of an optical amplifier. In the last decade the data capacity of a single optical fibre has grown way beyond all expectations. However, our ability to utilise the available capacity continues to keep pace with any advance. This project has the potential to add substantially to the transmission capacity by developing an optical amplifier at wavelengths which, although available within the fibre, can not currently be utilised. The focus of the project is the study of thulium doped silica-based fibres for amplification in the 1460 to 1530 nm wavelength region. Read moreRead less
High-performance smart solar powered on-chip capacitive energy storage. High performance and environmentally friendly on-chip power system is the key bottleneck issue limiting the further performance improvement and miniaturisation of ever-increasing portable optoelectronic devices. Building on previous work, including recent breakthroughs of on-chip photonic devices in patterned graphene oxide thin film and the record-breaking nanophotonics solar cells, the project aims to investigate a new con ....High-performance smart solar powered on-chip capacitive energy storage. High performance and environmentally friendly on-chip power system is the key bottleneck issue limiting the further performance improvement and miniaturisation of ever-increasing portable optoelectronic devices. Building on previous work, including recent breakthroughs of on-chip photonic devices in patterned graphene oxide thin film and the record-breaking nanophotonics solar cells, the project aims to investigate a new concept of super-resolution direct laser printing and simultaneous dopant activation of graphene oxide thin films. It is expected that the conceptually new development of the functional graphene oxide film patterning will allow for smart solar-powered on-chip power systems that outperform the state-of-the-art pollution generating batteries.Read moreRead less
Multi-dimensional optical data storage based on nanophotonics - the third generation optical data storage technology. The key-sector in high tech markets has been the photonics industry over the last decade, and it will continue to revolutionise our ways of information storage, processing and transfer for the next 10 to 20 years. The current project of high-capacity Petabyte optical data storage, i.e the third generation optical data storage, will prove to be the key technological innovation in ....Multi-dimensional optical data storage based on nanophotonics - the third generation optical data storage technology. The key-sector in high tech markets has been the photonics industry over the last decade, and it will continue to revolutionise our ways of information storage, processing and transfer for the next 10 to 20 years. The current project of high-capacity Petabyte optical data storage, i.e the third generation optical data storage, will prove to be the key technological innovation in photonics (one of the National Research Priorities), which will not only meet the growing demands of the consumer market, but also continue to drive the industry and create new markets. This is in line with the Priority Goals set by the Minister for Education, Science and Training, as it will put Australia into the unique position in the information age. Read moreRead less
Nano-photonic fabrication and storage using near-field super-resolving probes. The aim of the project is to develop a novel near-field storage device and nano-fabrication instruments, which are based on the super-resolution technique. As a result, the new storage device has a density 100 times of the current DVD technology. The nano-fabrication techniques can be used for all optics devices of nanometer resolution for fast information transferring. This project extends the key developments in t ....Nano-photonic fabrication and storage using near-field super-resolving probes. The aim of the project is to develop a novel near-field storage device and nano-fabrication instruments, which are based on the super-resolution technique. As a result, the new storage device has a density 100 times of the current DVD technology. The nano-fabrication techniques can be used for all optics devices of nanometer resolution for fast information transferring. This project extends the key developments in the field of nano-photonics and will put Australia in a uniquely strong position in the internationally competitive information technology field.Read moreRead less
Development of three-dimensional high-density optical data storage and photonic crystals in photo-polymers with a superresolution imaging system. The aim of this project is to develop a three-dimensional (3-D) high-density optical data storage method and photonic crystals in photo-polymers using a superresolution imaging system. As a result, it is possible to produce a 3-D data density of approximately 10 Tbits/cm3 in low-cost and erasable photo-polymers, equivalent to 3000 times the information ....Development of three-dimensional high-density optical data storage and photonic crystals in photo-polymers with a superresolution imaging system. The aim of this project is to develop a three-dimensional (3-D) high-density optical data storage method and photonic crystals in photo-polymers using a superresolution imaging system. As a result, it is possible to produce a 3-D data density of approximately 10 Tbits/cm3 in low-cost and erasable photo-polymers, equivalent to 3000 times the information in a current digital video disc (DVD). 3-D polymer-based photonic crystals will provide fast, low-cost and compact all-optics devices for optical computing technology. Consequently, the capacity and speed of information super-highways will be significantly increased, which enhances the internationally competitive ability of Australia in information technology.Read moreRead less
Nanophotonic metamaterials as anti-counterfeit devices in Australian banknotes. This project will demonstrate the application of novel materials as the basis for next generation security features on banknotes. Such elements play a key role in maintaining the integrity of Australia's currency since they present a significant barrier to counterfeiting.
A versatile optical wavelength and mode switching device for future telecommunication networks. This project will develop a next generation switching device for future fibre optical communication networks that will divide their information among several modes of specialty fibre. This device will be a key component for allowing network operators to move to these novel mode-multiplexed networks in order to overcome the looming capacity crunch.
Identifying Target Genes For Novel Anti-epileptic Therapies In The Mouse
Funder
National Health and Medical Research Council
Funding Amount
$469,802.00
Summary
Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not respo ....Epilepsy is a disease which affects 2-4% of the population. There are a wide range of drugs available to treat the condition but there is consistently 30-40% of patients who do not respond well to any of these drugs and who continue to have seizures. The reason that there are no drugs available for these people is that most of the drugs available have been designed along the same principles. A new set of principles is needed to develop new drugs which will be able to treat those people not responding to current therapy. This project is designed to identify new biologic pathways which may be interrupted with drugs to prevent seizures in people with epilepsy. This project uses a procedure to induce mutations into genes in mice and then screens for mice which do not seize when challenged with a drug which generates seizures in mice. Genetic studies will identify the mutated genes and these will be used as potential targets for new therapies or will identify new biological pathway which should expand the use of future anti-epileptic drugs.Read moreRead less