The Effect Of Titanium Surface Modification On The Immuno-regulation Of Osseointegration.
Funder
National Health and Medical Research Council
Funding Amount
$308,713.00
Summary
Titanium implants are an established treatment modality in both dentistry and orthopaedics. This project will determine how implant surface modification can modulate the inflammatory response and subsequent differentiation of stem cells involved in the process of integrating the implant with bone i.e. osseointegration. The identification of the molecular mechanisms involved will thus provide leads for novel ways to further to enhance the osseointegration process and improve clinical outcomes.
Targeting Histone Deacetylases 1 And 5 To Reduce Inflammation And Bone Loss In Periodontitis.
Funder
National Health and Medical Research Council
Funding Amount
$536,745.00
Summary
Bone loss and tooth loosening are serious complications in periodontitis. Despite the prevalence of this disease current treatments do not directly stop the bone loss. Our recent laboratory studies show inhibiting histone deacetylase (HDAC) activity with very low doses of inhibitors can effectively suppress this bone loss in periodontitis. This project aims to investigate specific targeting inhibitors of HDAC 1 and HDAC 5 to treat periodontitis by enhancing bone formation and reducing bone loss.