The Role Of Raptor And Rictor Signalling Pathways In Osteogenesis And Mesenchymal Stem Cell Fate Determination
Funder
National Health and Medical Research Council
Funding Amount
$562,742.00
Summary
Skeletal diseases associated with excessive bone loss and skeletal fragility, such as osteoporosis, affect 2.2 million Australians and cost our health system approximately $7.4 billion per annum. Studies from our laboratory suggest a critical role for the mTOR signalling pathway in bone development. Using transgenic animals and state-of-the-art techniques, we will investigate the role of mTOR in pre- and post-natal skeletal development. Results from these studies may provide novel approaches to ....Skeletal diseases associated with excessive bone loss and skeletal fragility, such as osteoporosis, affect 2.2 million Australians and cost our health system approximately $7.4 billion per annum. Studies from our laboratory suggest a critical role for the mTOR signalling pathway in bone development. Using transgenic animals and state-of-the-art techniques, we will investigate the role of mTOR in pre- and post-natal skeletal development. Results from these studies may provide novel approaches to treat age-related bone loss syndromes.Read moreRead less