Enhancing Joint Replacement Outcomes Through National Data Linkage
Funder
National Health and Medical Research Council
Funding Amount
$776,063.00
Summary
This is an Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) project that involves linking Registry data with state and federal government health datasets. This will help to better understand the complications and factors affecting the rate of complication after hip, knee and shoulder joint replacement. This information will be used to improve outcomes for patients having this surgery.
Prevention And Treatment Of Bone Infection With CSA-90
Funder
National Health and Medical Research Council
Funding Amount
$350,983.00
Summary
Bone infections are a major challenge to treat, especially with the rise of drug resistant “superbugs”. We have access to a new agent, CSA-90, that has dual properties of being anti-microbial (antibiotic) and helps encourage bone growth. This project aims to expand upon our prior research and test CSA-90 for the treatment of chronic bone infections. We will also look at applying this technology to joint replacements and this drug may be particularly useful for coating orthopaedic implants.
Paget's Disease Of Bone Associated Sequestosome 1/p62 Mutations In Autophagy-mediated Processes And Bone Resorption
Funder
National Health and Medical Research Council
Funding Amount
$474,892.00
Summary
Paget’s disease of bone (PDB) is a common, chronic bone disorder characterized by focal lesions of increased bone degradation initiated by giant overactive osteoclasts. Subsequent bone formation is irregular, resulting in bones that are structurally weak. Genetic mutations are a common cause of PDB in Caucasians. Understanding the genetic mutations and their regulation on bone cells may lead to the discovery of a new drug target for the treatment of PDB.
The Arthroplasty And Bariatric Surgery (ABS) Study: A Randomised Controlled Trial Of Laparoscopic Adjustable Gastric Banding Prior To Total Knee Arthroplasty
Funder
National Health and Medical Research Council
Funding Amount
$664,149.00
Summary
Knee replacement is a common surgical procedure in Australia (40,000 per year). More than 60% of this group are obese and this is associated with higher early (clinical) and long term (implant) survival complications. Laparoscopic adjustable gastric banding (LAGB) is an effective and safe means of achieving sustained weight loss. This study compares the outcomes of total knee replacement in groups of obese patients who have and have not undergone pre-knee replacement LAGB.
Bisphosphonate Treatment Of Childhood Femoral Head Avascular Necrosis Due To Perthes Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,368,242.00
Summary
Perthes disease (PD) occurs following loss of blood supply to the hip (femoral head). It is a severe childhood disorder with over 250 new cases per year in Australia. PD results in flattening of the normally round femoral head and painful arthritis. The hip becomes flat because the bone is eaten by cells called osteoclasts. We will test if a medicine aimed at stopping these osteoclasts can prevent hip flattening. This should decrease the risk of arthritis and the need for hip replacement.